Shank3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comShank3 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Shank3(Gene name) > Rat

Shank3 (Gene name),

SH3 and multiple ankyrin repeat domains protein 3 (Protein name ), SHAN3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Shank3(Prosap2);

Protein name:

SH3 and multiple ankyrin repeat domains protein 3(Shank3);

Alternative:

SPANK-2;Proline-rich synapse-associated protein 2(ProSAP2);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

May homomultimerize via its SAM domain. Interacts with BAIAP2 (By similarity). Interacts with DLGAP1/GKAP, MGLUR1A and MGLUR5 C-termini via its PDZ domain. Interacts with HOMER1, HOMER2, HOMER3 and CCTN/cortactin SH3 domain. Is part of a complex with DLG4/PSD-95 and DLGAP1/GKAP. Interacts with DBNL. Interacts (via PDZ domain) with PROSAPIP1 (via C-terminus).

Function:

Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Subcellular Location:

Cytoplasm Cell junction synapse Cell junction synapse postsynaptic cell membrane postsynaptic density Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.

Protein Attributes:

Sequence length:

1815

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HRMNIERALR | QLDGS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9JLU4

UniGene:

Rn.42876

KEGG:

rno:59312

String:

Q9JLU4

Pfam:

PF12796

Uniprot:

Q9JLU4

FOR

ELISA Kit for Rat Shank3

CLIA Kit for Rat Shank3

Polyclonal Antibody for Rat Shank3

Monoclonal Antibody for Rat Shank3

Protein for Rat Shank3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family."
Boeckers T.M. , Winter C. , Smalla K.-H. , Kreutz M.R. , Bockmann J. , Seidenbecher C. , Garner C.C. , Gundelfinger E.D.
Biochem. Biophys. Res. Commun.264:247-252(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH DLGAP1 AND DLG4;TISSUE SPECIFICITY
2.

"Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin."
Naisbitt S. , Kim E. , Tu J.C. , Xiao B. , Sala C. , Valtschanoff J. , Weinberg R.J. , Worley P.F. , Sheng M.
Neuron23:569-582(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH DLGAP1 AND CTTN;OLIGOMERIZATION
strain: Sprague-Dawley.
tissue: Hippocampus.
3.

"The G protein-coupled receptor CL1 interacts directly with proteins of the Shank family."
Tobaben S. , Suedhof T.C. , Stahl B.
J. Biol. Chem.275:36204-36210(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Brain.
4.

"Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins."
Tu J.C. , Xiao B. , Naisbitt S. , Yuan J.P. , Petralia R.S. , Brakeman P. , Doan A. , Aakalu V.K. , Lanahan A.A. , Sheng M. , Worley P.F.
Neuron23:583-592(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HOMER1; HOMER2; HOMER3; DLGAP1; MGLUR1A AND MGLUR5;MUTAGENESIS OF PRO-1311 AND PHE-1314
5.

"The Shank family of scaffold proteins."
Sheng M. , Kim E.
J. Cell Sci.113:1851-1856(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
6.

"Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family."
Qualmann B. , Boeckers T.M. , Jeromin M. , Gundelfinger E.D. , Kessels M.M.
J. Neurosci.24:2481-2495(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DBNL;TISSUE SPECIFICITY
7.

"ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3."
Wendholt D. , Spilker C. , Schmitt A. , Dolnik A. , Smalla K.H. , Proepper C. , Bockmann J. , Sobue K. , Gundelfinger E.D. , Kreutz M.R. , Boeckers T.M.
J. Biol. Chem.281:13805-13816(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LZTS3;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"Abelson interacting protein 1 (Abi-1) is essential for dendrite morphogenesis and synapse formation."
Proepper C. , Johannsen S. , Liebau S. , Dahl J. , Vaida B. , Bockmann J. , Kreutz M.R. , Gundelfinger E.D. , Boeckers T.M.
EMBO J.26:1397-1409(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ABI1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF PRO-677; PRO-678; PRO-679; PRO-680 AND PRO-684
9.

"Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses."
Verpelli C. , Dvoretskova E. , Vicidomini C. , Rossi F. , Chiappalone M. , Schoen M. , Di Stefano B. , Mantegazza R. , Broccoli V. , Boeckers T.M. , Dityatev A. , Sala C.
J. Biol. Chem.286:34839-34850(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MGLUR5 SIGNALING REGULATION;TISSUE SPECIFICITY
10.

"Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling."
Arons M.H. , Thynne C.J. , Grabrucker A.M. , Li D. , Schoen M. , Cheyne J.E. , Boeckers T.M. , Montgomery J.M. , Garner C.C.
J. Neurosci.32:14966-14978(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ARG-12; ARG-300 AND GLN-321
11.

"SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism."
Durand C.M. , Perroy J. , Loll F. , Perrais D. , Fagni L. , Bourgeron T. , Montcouquiol M. , Sans N.
Mol. Psychiatry17:71-84(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACTIN-BINDING;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-12; ARG-300 AND GLN-321
12.

"SHANK3 gene mutations associated with autism facilitate ligand binding to the Shank3 ankyrin repeat region."
Mameza M.G. , Dvoretskova E. , Bamann M. , Hoenck H.H. , Gueler T. , Boeckers T.M. , Schoen M. , Verpelli C. , Sala C. , Barsukov I. , Dityatev A. , Kreienkamp H.J.
J. Biol. Chem.288:26697-26708(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DOMAIN;INTERACTION WITH SHARPIN AND SPTAN1;SUBCELLULAR LOCATION;MUTAGENESIS OF LEU-68; ARG-300 AND GLN-321
13.

"Shank3 deficiency induces NMDA receptor hypofunction via an actin-dependent mechanism."
Duffney L.J. , Wei J. , Cheng J. , Liu W. , Smith K.R. , Kittler J.T. , Yan Z.
J. Neurosci.33:15767-15778(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NMDA RECEPTOR SIGNALING REGULATION
14.

"An architectural framework that may lie at the core of the postsynaptic density."
Baron M.K. , Boeckers T.M. , Vaida B. , Faham S. , Gingery M. , Sawaya M.R. , Salyer D. , Gundelfinger E.D. , Bowie J.U.
Science311:531-535(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1674-1740

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