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Index > Protein center > Tpx2(Gene name) > Mouse
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  • Tpx2 (Gene name),
  • Targeting protein for Xklp2 (Protein name ),  TPX2_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Tpx2;
    Protein name:
    Targeting protein for Xklp2;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with AURKA.
    Function:
    Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton spindle Cytoplasm cytoskeleton spindle pole During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
    Protein Attributes:
    Sequence length:
    745
    Sequence:
    50:
    MSQVPTTYSF | DAPTDFINFS | SLDAEEDTEN | IDSWFDEKAN | LENKFLRQRG | 
    100:
    IGEPFQGKNS | LRKAKLQQGF | VTPLKAVDNT | YHKETEKENL | QKQSIPSNDC | 
    150:
    SSLDAKRAVS | GNTPVQPQRR | SIRLSAQKDL | EQKEKNHVAS | VEMKAKRCVA | 
    200:
    PATDCPPQKR | MKVSHKKKLE | EEEEGSAPAT | SRKNERETLE | KAKGKHTVPG | 
    250:
    VPPAREKVLK | STEEQEIEKR | LRMQQEVVEL | RRKNEEFKKL | ALAGPGQPVK | 
    300:
    KSTSQVTKTV | DFHFLTDERI | KQHPKNQEEY | KEVNFMSELR | KHSSTPARGT | 
    350:
    RGCTIIKPFN | LSKGKKRTFD | EAASTYVPIA | QQVEAFHKRT | PNRYHLRNKK | 
    400:
    DESLLPSKSV | NKIARDPQTP | ILQTKYRTRA | VTCKSTAEQE | AEELEKLQQY | 
    450:
    KFKARELDPR | IFESGPILPK | RAPVKPPTQP | VGFDLEIEKR | IHERESKKKT | 
    500:
    EDEQFEFHSR | PCPTKILEDV | VGVPEKKVIP | ATVPKSPVFA | LKNRIRVPIK | 
    550:
    DEEEEKPVVI | KAQPVPHYGV | PYKPHIAEAR | NVEVCPFSFD | TRDKERQLQK | 
    600:
    EKKIKEMQKG | EVPKFKALPV | PHFDTINLPE | KKVKNVTQAE | PFSLETDKRG | 
    650:
    AYKAEMWKHQ | LEEEQKQQKD | AACFKARPNT | VIFQEPFVPK | KEKKSLAENP | 
    700:
    SGSLVQEPFQ | LATERRAKER | QELEKKMAEV | EAWKLQQLEE | VRQQEEEQQK | 
    745:
    EELARLRKEL | VHKANPIRKY | AAVEVKSSEL | PLTVPVSPKF | STRFQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Targeting protein for Xklp2
    ELISA Kit for Mouse Targeting protein for Xklp2
    ELISA Kit for Mouse Targeting protein for Xklp2
    CLIA Kit for Mouse Targeting protein for Xklp2
    CLIA Kit for Mouse Targeting protein for Xklp2
    CLIA Kit for Mouse Targeting protein for Xklp2
    Polyclonal Antibody for Mouse Targeting protein for Xklp2
    Polyclonal Antibody for Mouse Targeting protein for Xklp2
    Polyclonal Antibody for Mouse Targeting protein for Xklp2
    Monoclonal Antibody for Mouse Targeting protein for Xklp2
    Monoclonal Antibody for Mouse Targeting protein for Xklp2
    Monoclonal Antibody for Mouse Targeting protein for Xklp2
    Protein for Mouse Targeting protein for Xklp2
    Protein for Mouse Targeting protein for Xklp2
    Protein for Mouse Targeting protein for Xklp2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: NOD.
      tissue: Thymus.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72 AND SER-486;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    6. 6.
      "Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A."
      Bird A.W. , Hyman A.A.
      J. Cell Biol.182:289-300(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AURKA;SUBCELLULAR LOCATION;MUTAGENESIS OF 8-TYR--ASP-11
    7. 7.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    8. 8.
      "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
      Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-128 AND LYS-375;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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