Protein name:
Targeting protein for Xklp2 ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with AURKA.
Function:
Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation and protects the phosphorylated residue against dephosphorylation.
Subcellular Location:
Nucleus
Cytoplasm
cytoskeleton
spindle
Cytoplasm
cytoskeleton
spindle pole
During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules.
Protein Attributes:
50:
MSQVPTTYSF | DAPTDFINFS | SLDAEEDTEN | IDSWFDEKAN | LENKFLRQRG |
100:
IGEPFQGKNS | LRKAKLQQGF | VTPLKAVDNT | YHKETEKENL | QKQSIPSNDC |
150:
SSLDAKRAVS | GNTPVQPQRR | SIRLSAQKDL | EQKEKNHVAS | VEMKAKRCVA |
200:
PATDCPPQKR | MKVSHKKKLE | EEEEGSAPAT | SRKNERETLE | KAKGKHTVPG |
250:
VPPAREKVLK | STEEQEIEKR | LRMQQEVVEL | RRKNEEFKKL | ALAGPGQPVK |
300:
KSTSQVTKTV | DFHFLTDERI | KQHPKNQEEY | KEVNFMSELR | KHSSTPARGT |
350:
RGCTIIKPFN | LSKGKKRTFD | EAASTYVPIA | QQVEAFHKRT | PNRYHLRNKK |
400:
DESLLPSKSV | NKIARDPQTP | ILQTKYRTRA | VTCKSTAEQE | AEELEKLQQY |
450:
KFKARELDPR | IFESGPILPK | RAPVKPPTQP | VGFDLEIEKR | IHERESKKKT |
500:
EDEQFEFHSR | PCPTKILEDV | VGVPEKKVIP | ATVPKSPVFA | LKNRIRVPIK |
550:
DEEEEKPVVI | KAQPVPHYGV | PYKPHIAEAR | NVEVCPFSFD | TRDKERQLQK |
600:
EKKIKEMQKG | EVPKFKALPV | PHFDTINLPE | KKVKNVTQAE | PFSLETDKRG |
650:
AYKAEMWKHQ | LEEEQKQQKD | AACFKARPNT | VIFQEPFVPK | KEKKSLAENP |
700:
SGSLVQEPFQ | LATERRAKER | QELEKKMAEV | EAWKLQQLEE | VRQQEEEQQK |
745:
EELARLRKEL | VHKANPIRKY | AAVEVKSSEL | PLTVPVSPKF | STRFQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Mouse
Human
ELISA Kit for Mouse Targeting protein for Xklp2
ELISA Kit for Mouse Targeting protein for Xklp2
ELISA Kit for Mouse Targeting protein for Xklp2
CLIA Kit for Mouse Targeting protein for Xklp2
CLIA Kit for Mouse Targeting protein for Xklp2
CLIA Kit for Mouse Targeting protein for Xklp2
Polyclonal Antibody for Mouse Targeting protein for Xklp2
Polyclonal Antibody for Mouse Targeting protein for Xklp2
Polyclonal Antibody for Mouse Targeting protein for Xklp2
Monoclonal Antibody for Mouse Targeting protein for Xklp2
Monoclonal Antibody for Mouse Targeting protein for Xklp2
Monoclonal Antibody for Mouse Targeting protein for Xklp2
Protein for Mouse Targeting protein for Xklp2
Protein for Mouse Targeting protein for Xklp2
Protein for Mouse Targeting protein for Xklp2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
NOD .
tissue :
Thymus .
2.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
,
Schwartz D.C.
,
Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-72 AND SER-486;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH AURKA;SUBCELLULAR LOCATION;MUTAGENESIS OF 8-TYR--ASP-11
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-128 AND LYS-375;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .