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Index > Protein center > Trim63(Gene name) > Mouse
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  • Trim63 (Gene name),
  • E3 ubiquitin-protein ligase TRIM63 (Protein name ),  TRI63_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Trim63(Murf1;Rf1);
    Protein name:
    E3 ubiquitin-protein ligase TRIM63;
    Alternative:
    Tripartite motif-containing protein 63;Muscle-specific RING finger protein 1(MuRF-1;MuRF1;Muscle RING finger protein 1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 (By similarity). Interacts with TNNI3. Forms a ternary complex with GNB2L1 and PRKCE.
    Function:
    E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
    Subcellular Location:
    Cytoplasm Nucleus Cytoplasm myofibril sarcomere M line Cytoplasm myofibril sarcomere Z line Localizes to the M- and Z-lines in skeletal muscle (By similarity). Colocalizes with TNNI3 in myocytes.
    Protein Attributes:
    Sequence length:
    350
    Sequence:
    50:
    MDYKSGLIPD | GNAMENLEKQ | LICPICLEMF | TKPVVILPCQ | HNLCRKCAND | 
    100:
    IFQAANPYWT | NRGGSVSMSG | GRFRCPSCRH | EVIMDRHGVY | GLQRNLLVEN | 
    150:
    IIDIYKQECS | SRPLQKGSHP | MCKEHEDEKI | NIYCLTCEVP | TCSLCKVFGA | 
    200:
    HQACEVAPLQ | SIFQGQKTEL | SNCISMLVAG | NDRVQTIISQ | LVDSCRVTKE | 
    250:
    NSHQVKEELS | QKFDTLYAIL | DEKKSELLQR | ITQEQEEKLG | FIEALILQYR | 
    300:
    EQLEKSTKLV | ETAIQSLDEP | GGATFLSSAK | QLIKSNVEAS | KGCQLGKTEQ | 
    350:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    E5054r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    E5054m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    E5054h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    U5054h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Cat.:
    P5054Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase TRIM63
    Protein for Mouse E3 ubiquitin-protein ligase TRIM63
    Protein for Mouse E3 ubiquitin-protein ligase TRIM63
    Protein for Mouse E3 ubiquitin-protein ligase TRIM63

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    Precision
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    Linearity
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    References
    1. 1.
      "Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I."
      Kedar V. , McDonough H. , Arya R. , Li H.-H. , Rockman H.A. , Patterson C.
      Proc. Natl. Acad. Sci. U.S.A.101:18135-18140(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION AS AN E3 UBIQUITIN LIGASE;INTERACTION WITH TNNI3;DOMAIN;SUBCELLULAR LOCATION
      strain: C57BL/6.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Heart.
    3. 3.
      Lubec G. , Sunyer B. , Chen W.-Q.
      Submitted (2009-01) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 197-212;IDENTIFICATION BY MASS SPECTROMETRY
      strain: OF1.
      tissue: Hippocampus.
    4. 4.
      "Hydrogen peroxide stimulates ubiquitin-conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal muscle myotubes."
      Li Y.-P. , Chen Y. , Li A.S. , Reid M.B.
      Am. J. Physiol.285:C806-C812(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    5. 5.
      "Muscle ring finger protein-1 inhibits PKC-epsilon activation and prevents cardiomyocyte hypertrophy."
      Arya R. , Kedar V. , Hwang J.R. , McDonough H. , Li H.-H. , Taylor J. , Patterson C.
      J. Cell Biol.167:1147-1159(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GNB2L1 AND PRKCE
    6. 6.
      "Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis."
      Koyama S. , Hata S. , Witt C.C. , Ono Y. , Lerche S. , Ojima K. , Chiba T. , Doi N. , Kitamura F. , Tanaka K. , Abe K. , Witt S.H. , Rybin V. , Gasch A. , Franz T. , Labeit S. , Sorimachi H.
      J. Mol. Biol.376:1224-1236(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;INTERACTION WITH CKM;INDUCTION
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