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Index > Protein center > TXNIP(Gene name) > Pig
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  • TXNIP (Gene name),
  • Thioredoxin-interacting protein (Protein name ),  TXNIP_PIG from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    TXNIP;
    Protein name:
    Thioredoxin-interacting protein;
    Alternative:

    Organism:
    Pig (Sus scrofa). 
    General Annotation
    Sub Unit:
    Interacts with TXN/thioredoxin through its redox-active site. Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (By similarity). Interacts (via C-terminus) with ITCH (via WW domains).
    Function:
    May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    391
    Sequence:
    50:
    MVMFKKIKSF | EVVFNDPEKV | YGCGEKVAGR | VIVEVCEVTR | IKAVRILACG | 
    100:
    VAKVLWMQGS | QQCKQTLDYL | RYEDTLLLDD | HPTGENEMVI | MRPGNKYEYK | 
    150:
    FGFELPQGPL | GTSFKGKYGC | VDYWVKAFLD | RPSQPTQETK | KHFEVMDLVD | 
    200:
    VNTPDLMAPV | SAKKEKKVSC | MFIPDGRVSV | SARIDRKGFC | EGDEINIHAD | 
    250:
    FENTCSRIVV | PKAAIVARHT | YLANGQTKVL | TQKLSSVRGN | HIISGTCASW | 
    300:
    RGKSLRVQKI | RPSILGCNIL | RVEYFLLIYV | SVPGSKKVIL | DLPLVIGSRS | 
    350:
    GLSSRTSSMA | SRTSSEMSWV | DLNIPDTPEA | PPCYMDIIPE | DHRLESPTTP | 
    391:
    LLDDTDGSQD | SPIFMYAPEF | KFMPPPTYSE | VDPCILNNNV | Q
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    E1162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    E1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    E1162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    E1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    U1162r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    U1162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    U1162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Pig Thioredoxin-interacting protein
    Cat.:
    U1162p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Pig Thioredoxin-interacting protein
    Cat.:
    P1162Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig Thioredoxin-interacting protein
    Cat.:
    P1162Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Pig Thioredoxin-interacting protein
    Polyclonal Antibody for Pig Thioredoxin-interacting protein
    Cat.:
    P1162Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Pig Thioredoxin-interacting protein
    Monoclonal Antibody for Pig Thioredoxin-interacting protein
    Monoclonal Antibody for Pig Thioredoxin-interacting protein
    Monoclonal Antibody for Pig Thioredoxin-interacting protein
    Protein for Pig Thioredoxin-interacting protein
    Protein for Pig Thioredoxin-interacting protein
    Protein for Pig Thioredoxin-interacting protein
    Protein for Pig Thioredoxin-interacting protein

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    Citations
    [1].
    Seok Kyo Seo, Hyo In Yang, Kyung Eun Lee, Hye Yeon Kim, SiHyun Cho, Young Sik Choi and Byung Seok Lee
    References
    1. 1.
      "Investigation of TXNIP (thioredoxin-interacting protein) and TRX (thioredoxin) genes for growth-related traits in pigs."
      Yu M. , Geiger B. , Deeb N. , Rothschild M.F.
      Mamm. Genome18:197-209(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Polymorphism and association with production traits of porcine TXNIP gene."
      Xu D.Q. , Ling X.F. , Xiong Y.Z.
      Submitted (2005-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Molecular cloning and characterization of porcine TXNIP."
      Xu D.Q. , Xiong Y.Z.
      Submitted (2006-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
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