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Index > Protein center > USP21(Gene name) > Human
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  • USP21 (Gene name),
  • Ubiquitin carboxyl-terminal hydrolase 21 (Protein name ),  UBP21_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    USP21(PP1490;USP23);
    Protein name:
    Ubiquitin carboxyl-terminal hydrolase 21;
    Alternative:
    Ubiquitin thiolesterase 21;Deubiquitinating enzyme 21;Ubiquitin-specific-processing protease 21;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    565
    Sequence:
    50:
    MPQASEHRLG | RTREPPVNIQ | PRVGSKLPFA | PRARSKERRN | PASGPNPMLR | 
    100:
    PLPPRPGLPD | ERLKKLELGR | GRTSGPRPRG | PLRADHGVPL | PGSPPPTVAL | 
    150:
    PLPSRTNLAR | SKSVSSGDLR | PMGIALGGHR | GTGELGAALS | RLALRPEPPT | 
    200:
    LRRSTSLRRL | GGFPGPPTLF | SIRTEPPASH | GSFHMISARS | SEPFYSDDKM | 
    250:
    AHHTLLLGSG | HVGLRNLGNT | CFLNAVLQCL | SSTRPLRDFC | LRRDFRQEVP | 
    300:
    GGGRAQELTE | AFADVIGALW | HPDSCEAVNP | TRFRAVFQKY | VPSFSGYSQQ | 
    350:
    DAQEFLKLLM | ERLHLEINRR | GRRAPPILAN | GPVPSPPRRG | GALLEEPELS | 
    400:
    DDDRANLMWK | RYLEREDSKI | VDLFVGQLKS | CLKCQACGYR | STTFEVFCDL | 
    450:
    SLPIPKKGFA | GGKVSLRDCF | NLFTKEEELE | SENAPVCDRC | RQKTRSTKKL | 
    500:
    TVQRFPRILV | LHLNRFSASR | GSIKKSSVGV | DFPLQRLSLG | DFASDKAGSP | 
    550:
    VYQLYALCNH | SGSVHYGHYT | ALCRCQTGWH | VYNDSRVSPV | SENQVASSEG | 
    565:
    YVLFYQLMQE | PPRCL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    ELISA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    CLIA Kit for Human Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Polyclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Monoclonal Antibody for Human Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 21
    Protein for Human Ubiquitin carboxyl-terminal hydrolase 21

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    Precision
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    Linearity
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    References
    1. 1.
      "Sequencing, tissue distribution and chromosomal assignment of a novel ubiquitin-specific protease USP23."
      Smith T.S. , Southan C.
      Biochim. Biophys. Acta1490:184-188(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Identification of a novel isopeptidase with dual specificity for ubiquitin- and NEDD8-conjugated proteins."
      Gong L. , Kamitani T. , Millas S. , Yeh E.T.H.
      J. Biol. Chem.275:14212-14216(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;MUTAGENESIS OF CYS-221
      tissue: Placenta.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
      tissue: Lung.
      tissue: Testis.
    9. 9.
      "A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family."
      Garcia-Santisteban I. , Banuelos S. , Rodriguez J.A.
      Biochem. J.441:209-217(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;NUCLEAR EXPORT SIGNAL
    10. 10.
      "Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21."
      Ye Y. , Akutsu M. , Reyes-Turcu F. , Enchev R.I. , Wilkinson K.D. , Komander D.
      EMBO Rep.12:350-357(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.59 ANGSTROMS) OF 1-75 IN COMPLEX WITH USP21
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