Gene name:
UGT1A1 (GNT1;UGT1) ;
Protein name:
UDP-glucuronosyltransferase 1-1 (UDPGT 1-1;UGT1*1;UGT1-01;UGT1.1) ;
Alternative:
UDP-glucuronosyltransferase 1-A (UGT-1A;UGT1A) ;Bilirubin-specific UDPGT isozyme 1 (hUG-BR1) ;UDP-glucuronosyltransferase 1A1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
Function:
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Subcellular Location:
Microsome
Endoplasmic reticulum membrane
Single-pass membrane protein
Protein Attributes:
50:
MAVESQGGRP | LVLGLLLCVL | GPVVSHAGKI | LLIPVDGSHW | LSMLGAIQQL |
100:
QQRGHEIVVL | APDASLYIRD | GAFYTLKTYP | VPFQREDVKE | SFVSLGHNVF |
150:
ENDSFLQRVI | KTYKKIKKDS | AMLLSGCSHL | LHNKELMASL | AESSFDVMLT |
200:
DPFLPCSPIV | AQYLSLPTVF | FLHALPCSLE | FEATQCPNPF | SYVPRPLSSH |
250:
SDHMTFLQRV | KNMLIAFSQN | FLCDVVYSPY | ATLASEFLQR | EVTVQDLLSS |
300:
ASVWLFRSDF | VKDYPRPIMP | NMVFVGGINC | LHQNPLSQEF | EAYINASGEH |
350:
GIVVFSLGSM | VSEIPEKKAM | AIADALGKIP | QTVLWRYTGT | RPSNLANNTI |
400:
LVKWLPQNDL | LGHPMTRAFI | THAGSHGVYE | SICNGVPMVM | MPLFGDQMDN |
450:
AKRMETKGAG | VTLNVLEMTS | EDLENALKAV | INDKSYKENI | MRLSSLHKDR |
500:
PVEPLDLAVF | WVEFVMRHKG | APHLRPAAHD | LTWYQYHSLD | VIGFLLAVVL |
533:
TVAFITFKCC | AYGYRKCLGK | KGRVKKAHKS | KTH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human UDPGT 1-1
ELISA Kit for Human UDPGT 1-1
ELISA Kit for Human UDPGT 1-1
CLIA Kit for Human UDPGT 1-1
CLIA Kit for Human UDPGT 1-1
CLIA Kit for Human UDPGT 1-1
Polyclonal Antibody for Human UDPGT 1-1
Polyclonal Antibody for Human UDPGT 1-1
Polyclonal Antibody for Human UDPGT 1-1
Monoclonal Antibody for Human UDPGT 1-1
Monoclonal Antibody for Human UDPGT 1-1
Monoclonal Antibody for Human UDPGT 1-1
Protein for Human UDPGT 1-1
Protein for Human UDPGT 1-1
Protein for Human UDPGT 1-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : COMPONENT OF A CHAPERONE COMPLEX
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;FUNCTION (ISOFORM 2);SUBCELLULAR LOCATION;SUBUNIT;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;KINETIC PARAMETERS;SUBSTRATE SPECIFICITY;CHARACTERIZATION OF VARIANTS CN2 ARG-71; LEU-83; GLN-229 AND ASP-486
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING;CATALYTIC ACTIVITY;FUNCTION (ISOFORM 2);TISSUE SPECIFICITY
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBSTRATE SPECIFICITY;VARIANT CN1 THR-402;VARIANTS CN2 ARG-15; ARG-71; PHE-191; TRP-209; TRP-336; HIS-387; PRO-443 AND ASP-486;CHARACTERIZATION OF VARIANT CN1 THR-402;CHARACTERIZATION OF VARIANTS CN2 ARG-71; GLN-175; PHE-191; TRP-209; ARG-331; TRP-336; HIS-387; VAL-395 AND PRO-443
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14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-102
tissue :
Liver .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBUNIT
16.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN1 PHE-375
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN2 ARG-71 AND ASP-486
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN2 ARG-331
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN1 PHE-170 DEL
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN1 VAL-292; GLU-308; ARG-357; THR-368; ARG-381; PRO-401 AND GLU-428
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN1 GLU-308 AND PHE-375;CHARACTERIZATION OF VARIANTS CN1 GLU-308 AND PHE-375
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN1 PHE-170 DEL; ARG-177; ARG-276 AND PHE-375;VARIANTS CN2 GLN-175 AND TRP-209
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS GILBS ARG-71; GLN-229 AND GLY-367
tissue :
Liver .
tissue :
Peripheral blood leukocyte .
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN2 ARG-15;CHARACTERIZATION OF VARIANT CN2 ARG-15
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN2 THR-294;CHARACTERIZATION OF VARIANT CN2 THR-294
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN2 ARG-71; TRP-209; GLN-229 AND ASP-486
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GILBS ASP-486
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN1 ASP-39; PHE-170 DEL; ARG-177; ARG-276; VAL-291; GLU-308; TRP-336; ARG-357; THR-368; PHE-375; ARG-381; SER-387; PRO-401 AND GLU-428;VARIANTS CN2 ARG-15; GLN-175; TRP-209; GLY-225 AND ARG-331;VARIANTS GILBS ARG-71; GLN-229; THR-294; GLY-367 AND ASP-486
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS HBLRTFN ARG-71 AND ASP-486
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN2 GLN-175
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN2 ASP-400
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GILBS LEU-83
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION OF VARIANT CN2 ARG-15
34.
"Spectrum of UGT1A1 mutations in Crigler-Najjar (CN) syndrome patients: identification of twelve novel alleles and genotype-phenotype correlation."
Servedio V.
,
d'Apolito M.
,
Maiorano N.
,
Minuti B.
,
Torricelli F.
,
Ronchi F.
,
Zancan L.
,
Perrotta S.
,
Vajro P.
,
Boschetto L.
,
Iolascon A.
Hum. Mutat.25:325-325(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN1 GLN-336; ARG-357; PHE-375; SER-387 AND VAL-395;VARIANTS CN2 GLN-34; PHE-170 DEL; TRP-209; GLY-225; LEU-336; TRP-336; ARG-354; CYS-403 AND ASP-478;VARIANTS CN1/CN2 VAL-377 AND ARG-461
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN1 PHE-171 DEL;VARIANTS CN2 TYR-279; ARG-354; VAL-370; VAL-395; PRO-443 AND ARG-461
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT CN1 ASN-36;VARIANT CN2 CYS-230
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CN2 PHE-170 DEL AND CYS-367