Protein name:
Vinculin ;
Alternative:
Metavinculin ;
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
Exhibits self-association properties. Interacts with NRAP and TLN1. Interacts with CTNNB1 and this interaction is necessary for its localization to the cell-cell junctions and for its function in regulating cell surface expression of E-cadherin.
Function:
Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Subcellular Location:
Cytoplasm
cytoskeleton
Cell junction
adherens junction
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II-dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions.
Protein Attributes:
50:
MPVFHTRTIE | SILEPVAQQI | SHLVIMHEEG | EVDGKAIPDL | TAPVSAVQAA |
100:
VSNLVRVGKE | TVQTTEDQIL | KRDMPPAFIK | VENACTKLVR | AAQMLQADPY |
150:
SVPARDYLID | GSRGILSGTS | DLLLTFDEAE | VRKIIRVCKG | ILEYLTVAEV |
200:
VETMEDLVTY | TKNLGPGMTK | MAKMIDERQQ | ELTHQEHRVM | LVNSMNTVKE |
250:
LLPVLISAMK | IFVTTKNTKS | QGIEEALKNR | NFTVEKMSAE | INEIIRVLQL |
300:
TSWDEDAWAS | KDTEAMKRAL | ALIDSKMNQA | KGWLRDPNAP | PGDAGEQAIR |
350:
QILDEAGKAG | ELCAGKERRE | ILGTCKTLGQ | MTDQLADLRA | RGQGATPMAM |
400:
QKAQQVSQGL | DLLTAKVENA | ARKLEAMTNS | KQAIAKKIDA | AQNWLADPNG |
450:
GSEGEEHIRG | IMSEARKVAE | LCEEPKERDD | ILRSLGEISA | LTAKLSDLRR |
500:
HGKGDSPEAR | ALAKQIATSL | QNLQSKTNRA | VANTRPVKAA | VHLEGKIEQA |
550:
QRWIDNPTVD | DRGVGQAAIR | GLVAEGRRLA | NVMMGPYRQD | LLAKCDRVDQ |
600:
LAAQLADLAA | RGEGESPQAR | AIAAQLQDSL | KDLKARMQEA | MTQEVSDVFS |
650:
DTTTPIKLLA | VAATAPSDTP | NREEVFEERA | ANFENHAARL | GATAEKAAAV |
700:
GTANKTTVEG | IQATVKSARE | LTPQVVSAAR | ILLRNPGNQA | AYEHFETMKN |
750:
QWIDNVEKMT | GLVDEAIDTK | SLLDASEEAI | KKDLDKCKVA | MANMQPQMLV |
800:
AGATSIARRA | NRILLVAKRE | VENSEDPKFR | EAVKAASDEL | SKTISPMVMD |
850:
AKAVAGNISD | PGLQKSFLDS | GYRILGAVAK | VREAFQPQEP | DFPPPPPDLE |
900:
HLHLTDELAP | PKPPLPEGEV | PPPRPPPPEE | KDEEFPEQKA | GEAINQPMMM |
950:
AARQLHDEAR | KWSSKPVTVI | NEAAEAGVDI | DEEDDADVEF | SLPSDIEDDY |
1000:
EPELLLMPTN | QPVNQPILAA | AQSLHREATK | WSSKGNDIIA | AAKRMALLMA |
1050:
EMSRLVRGGS | GNKRALIQCA | KDIAKASDEV | TRLAKEVAKQ | CTDKRIRTNL |
1100:
LQVCERIPTI | STQLKILSTV | KATMLGRTNI | SDEESEQATE | MLVHNAQNLM |
1135:
QSVKETVREA | EAASIKIRTD | AGFTLRWVRK | TPWYQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Chicken
Pig
Human
Mouse
ELISA Kit for Chicken Vinculin
ELISA Kit for Chicken Vinculin
ELISA Kit for Chicken Vinculin
ELISA Kit for Chicken Vinculin
ELISA Kit for Chicken Vinculin
CLIA Kit for Chicken Vinculin
CLIA Kit for Chicken Vinculin
CLIA Kit for Chicken Vinculin
CLIA Kit for Chicken Vinculin
CLIA Kit for Chicken Vinculin
Polyclonal Antibody for Chicken Vinculin
Polyclonal Antibody for Chicken Vinculin
Polyclonal Antibody for Chicken Vinculin
Polyclonal Antibody for Chicken Vinculin
Polyclonal Antibody for Chicken Vinculin
Monoclonal Antibody for Chicken Vinculin
Monoclonal Antibody for Chicken Vinculin
Monoclonal Antibody for Chicken Vinculin
Monoclonal Antibody for Chicken Vinculin
Monoclonal Antibody for Chicken Vinculin
Protein for Chicken Vinculin
Protein for Chicken Vinculin
Protein for Chicken Vinculin
Protein for Chicken Vinculin
Protein for Chicken Vinculin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Embryo .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Embryo .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 2)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-881
tissue :
Embryo .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TALIN INTERACTION DOMAIN
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NRAP
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-100 AND TYR-1134;FUNCTION;MUTAGENESIS OF TYR-100; TYR-160; TYR-537; TYR-692; TYR-822 AND TYR-1134
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CTNNB1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 881-1135 OF ISOFORM 1
12.
"RIAM and vinculin binding to talin are mutually exclusive and regulate adhesion assembly and turnover."
Goult B.T.
,
Zacharchenko T.
,
Bate N.
,
Tsang R.
,
Hey F.
,
Gingras A.R.
,
Elliott P.R.
,
Roberts G.C.
,
Ballestrem C.
,
Critchley D.R.
,
Barsukov I.L.
J. Biol. Chem.288:8238-8249(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-259 IN COMPLEX WITH APBB1IP;INTERACTION WITH TLN1 AND APBB1IP