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Index > Protein center > WDR34(Gene name) > Human
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  • WDR34 (Gene name),
  • WD repeat-containing protein 34 (Protein name ),  WDR34_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    WDR34;
    Protein name:
    WD repeat-containing protein 34;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains).
    Function:
    Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    536
    Sequence:
    50:
    MATRAQPGPL | SQAGSAGVAA | LATVGVASGP | GPGRPGPLQD | ETLGVASVPS | 
    100:
    QWRAVQGIRW | ETKSCQTASI | ATASASAQAR | NHVDAQVQTE | APVPVSVQPP | 
    150:
    SQYDIPRLAA | FLRRVEAMVI | RELNKNWQSH | AFDGFEVNWT | EQQQMVSCLY | 
    200:
    TLGYPPAQAQ | GLHVTSISWN | STGSVVACAY | GRLDHGDWST | LKSFVCAWNL | 
    250:
    DRRDLRPQQP | SAVVEVPSAV | LCLAFHPTQP | SHVAGGLYSG | EVLVWDLSRL | 
    300:
    EDPLLWRTGL | TDDTHTDPVS | QVVWLPEPGH | SHRFQVLSVA | TDGKVLLWQG | 
    350:
    IGVGQLQLTE | GFALVMQQLP | RSTKLKKHPR | GETEVGATAV | AFSSFDPRLF | 
    400:
    ILGTEGGFPL | KCSLAAGEAA | LTRMPSSVPL | RAPAQFTFSP | HGGPIYSVSC | 
    450:
    SPFHRNLFLS | AGTDGHVHLY | SMLQAPPLTS | LQLSLKYLFA | VRWSPVRPLV | 
    500:
    FAAASGKGDV | QLFDLQKSSQ | KPTVLIKQTQ | DESPVYCLEF | NSQQTQLLAA | 
    536:
    GDAQGTVKVW | QLSTEFTEQG | PREAEDLDCL | AAEVAA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    String:
    UniGene:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human WD repeat-containing protein 34
    ELISA Kit for Human WD repeat-containing protein 34
    CLIA Kit for Human WD repeat-containing protein 34
    CLIA Kit for Human WD repeat-containing protein 34
    Polyclonal Antibody for Human WD repeat-containing protein 34
    Polyclonal Antibody for Human WD repeat-containing protein 34
    Monoclonal Antibody for Human WD repeat-containing protein 34
    Monoclonal Antibody for Human WD repeat-containing protein 34
    Protein for Human WD repeat-containing protein 34
    Protein for Human WD repeat-containing protein 34

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
    3. 3.
      "WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
      Gao D. , Wang R. , Li B. , Yang Y. , Zhai Z. , Chen D.Y.
      Cell. Mol. Life Sci.66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP3K7; TAB2; TAB3 AND TRAF6;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    4. 4.
      "WDR34 mutations that cause short-rib polydactyly syndrome type III/severe asphyxiating thoracic dysplasia reveal a role for the NF-kappaB pathway in cilia."
      Huber C. , Wu S. , Kim A.S. , Sigaudy S. , Sarukhanov A. , Serre V. , Baujat G. , Le Quan Sang K.H. , Rimoin D.L. , Cohn D.H. , Munnich A. , Krakow D. , Cormier-Daire V.
      Am. J. Hum. Genet.93:926-931(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS SRTD11 VAL-341; MET-354; GLN-447 AND TRP-447
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SRTD11 PHE-148; LEU-390; SER-393; ILE-410; ARG-436 AND TRP-447;VARIANTS VAL-22 AND CYS-206
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