Protein name:
WD repeat-containing protein 34 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via the WD domains) with MAP3K7 and TAB3. Interacts (via WD domains) with TAB2 (via C-terminus). Interacts (via WD domains) with TRAF6 (via TRAF-type domains).
Function:
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
Subcellular Location:
Cytoplasm
Protein Attributes:
50:
MATRAQPGPL | SQAGSAGVAA | LATVGVASGP | GPGRPGPLQD | ETLGVASVPS |
100:
QWRAVQGIRW | ETKSCQTASI | ATASASAQAR | NHVDAQVQTE | APVPVSVQPP |
150:
SQYDIPRLAA | FLRRVEAMVI | RELNKNWQSH | AFDGFEVNWT | EQQQMVSCLY |
200:
TLGYPPAQAQ | GLHVTSISWN | STGSVVACAY | GRLDHGDWST | LKSFVCAWNL |
250:
DRRDLRPQQP | SAVVEVPSAV | LCLAFHPTQP | SHVAGGLYSG | EVLVWDLSRL |
300:
EDPLLWRTGL | TDDTHTDPVS | QVVWLPEPGH | SHRFQVLSVA | TDGKVLLWQG |
350:
IGVGQLQLTE | GFALVMQQLP | RSTKLKKHPR | GETEVGATAV | AFSSFDPRLF |
400:
ILGTEGGFPL | KCSLAAGEAA | LTRMPSSVPL | RAPAQFTFSP | HGGPIYSVSC |
450:
SPFHRNLFLS | AGTDGHVHLY | SMLQAPPLTS | LQLSLKYLFA | VRWSPVRPLV |
500:
FAAASGKGDV | QLFDLQKSSQ | KPTVLIKQTQ | DESPVYCLEF | NSQQTQLLAA |
536:
GDAQGTVKVW | QLSTEFTEQG | PREAEDLDCL | AAEVAA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human WD repeat-containing protein 34
ELISA Kit for Human WD repeat-containing protein 34
CLIA Kit for Human WD repeat-containing protein 34
CLIA Kit for Human WD repeat-containing protein 34
Polyclonal Antibody for Human WD repeat-containing protein 34
Polyclonal Antibody for Human WD repeat-containing protein 34
Monoclonal Antibody for Human WD repeat-containing protein 34
Monoclonal Antibody for Human WD repeat-containing protein 34
Protein for Human WD repeat-containing protein 34
Protein for Human WD repeat-containing protein 34
R&D Technical Data
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
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more...
Nature429:369-374(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Lung .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MAP3K7; TAB2; TAB3 AND TRAF6;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;VARIANTS SRTD11 VAL-341; MET-354; GLN-447 AND TRP-447
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SRTD11 PHE-148; LEU-390; SER-393; ILE-410; ARG-436 AND TRP-447;VARIANTS VAL-22 AND CYS-206