Protein name:
Wilms tumor protein 1-interacting protein (WT1-interacting protein) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with CD2AP and WT1.
Function:
May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype.
Subcellular Location:
Cell junction
adherens junction
Nucleus
Translocates from cell-cell junctions to the nucleus in puromycin aminonucleoside-treated podocytes.
Protein Attributes:
50:
MQRSRTAADD | AALLLAGLGL | RESEPTAGSP | GRVRRGPRAV | DEAAPASGRR |
100:
GKGGCGGPEA | APDVPSRPER | GPRASLAGSD | GGSARSSGIS | LGYDQRHGPG |
150:
PGPPSGGSAR | SSVSSLGSRG | SAGACADLLP | PGVGPAPARS | PEPAQFPFPL |
200:
PSLPLPPGRE | GGPSAAERRL | EALTRELERA | LEARTARDYF | GICIKCGLGI |
250:
YGARQACQAM | GSLYHTDCFI | CDSCGRRLRG | KAFYNVGEKV | YCQEDFLYSG |
300:
FQQTADKCSV | CGHLIMEMIL | QALGKSYHPG | CFRCSVCNEC | LDGVPFTVDV |
350:
DNNIYCVRDY | HTVFAPKCAS | CARPILPAQG | CETTIRVVSM | DRDYHVECYH |
398:
CEDCGLQLSG | EEGRRCYPLE | GHLLCRRCHL | RRLGQGPLPS | PAVHVTEL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse WT1-interacting protein
ELISA Kit for Mouse WT1-interacting protein
CLIA Kit for Mouse WT1-interacting protein
CLIA Kit for Mouse WT1-interacting protein
Polyclonal Antibody for Mouse WT1-interacting protein
Polyclonal Antibody for Mouse WT1-interacting protein
Monoclonal Antibody for Mouse WT1-interacting protein
Monoclonal Antibody for Mouse WT1-interacting protein
Protein for Mouse WT1-interacting protein
Protein for Mouse WT1-interacting protein
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M.
,
Goodstadt L.
,
Hillier L.W.
,
Zody M.C.
,
Goldstein S.
,
She X.
,
Bult C.J.
,
Agarwala R.
,
Cherry J.L.
,
DiCuccio M.
,
Hlavina W.
,
Kapustin Y.
,
Meric P.
,
Maglott D.
,
Birtle Z.
,
Marques A.C.
,
Graves T.
,
Zhou S.
,
Teague B.
,
Potamousis K.
,
Churas C.
,
Place M.
,
Herschleb J.
,
Runnheim R.
,
Forrest D.
,
Amos-Landgraf J.
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Schwartz D.C.
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Cheng Z.
,
Lindblad-Toh K.
,
Eichler E.E.
,
Ponting C.P.
more...
PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Limb .
3.
"A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus."
Srichai M.B.
,
Konieczkowski M.
,
Padiyar A.
,
Konieczkowski D.J.
,
Mukherjee A.
,
Hayden P.S.
,
Kamat S.
,
El-Meanawy M.A.
,
Khan S.
,
Mundel P.
,
Lee S.B.
,
Bruggeman L.A.
,
Schelling J.R.
,
Sedor J.R.
J. Biol. Chem.279:14398-14408(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;INTERACTION WITH WT1 AND CD2AP
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SNAI1; SNAI2/SLUG AND SCRT1
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ROR2;HOMODIMERIZATION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH MAPK8IP3 AND DYNEIN INTERMEDIATE CHAIN;TISSUE SPECIFICITY
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION