NEDD4-like E3 ubiquitin-protein ligase WWP1 (Protein name
), WWP1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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Gene name:
WWP1;
Protein name:
NEDD4-like E3 ubiquitin-protein ligase WWP1;
Alternative:
WW domain-containing protein 1(Tiul1);Atrophin-1-interacting protein 5(AIP5);WW domain-containing protein 1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII. Interacts with RNF11 (By similarity). Interacts with SPG20. Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1. Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7. Interacts with SKIL isoform 1. Interacts with TP63 isoform 1 and isoform 2. Interacts with STAMBP and RNF11. Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase.
Function:
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7.
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Nucleus
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5 AND 6);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;UBIQUITINATION OF SMAD2 AND TGFBR1;INTERACTION WITH SMAD7 AND TGIF
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 191-870;INTERACTION WITH WBP1; WBP2; SCNN1A; SCNN1B AND SCNN1G
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Cited for: FUNCTION IN UBIQUITINATION OF TGFBR1; SMAD6 AND SMAD7;INTERACTION WITH SMAD1; SMAD2; SMAD3; SMAD5; SMAD6; SMAD7; TGFBR1; TGFBR2 AND SKIL
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Cited for: ACTIVATION BY NDFIP1 AND NDFIP2;AUTOUBIQUITINATION
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Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 546-917;MUTAGENESIS OF GLU-614; HIS-621; ASP-675; GLU-798; MET-804; GLU-806; ARG-845; GLN-848 AND ARG-855;FUNCTION
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Vaild Sequence:
