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Index > Protein center > XPNPEP2(Gene name) > Human
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  • XPNPEP2 (Gene name),
  • Xaa-Pro aminopeptidase 2 (Protein name ),  XPP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    XPNPEP2;
    Protein name:
    Xaa-Pro aminopeptidase 2;
    Alternative:
    Membrane-bound aminopeptidase P(Membrane-bound APP;Membrane-bound AmP;mAmP);Aminoacylproline aminopeptidase;X-Pro aminopeptidase 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer.
    Function:
    A metalloprotease that may play a role in the inflammatory process and other reactions produced in response to injury or infection. May also play a role in the metabolism of the vasodilator bradykinin.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    674
    Sequence:
    50:
    MARAHWGCCP | WLVLLCACAW | GHTKPVDLGG | QDVRNCSTNP | PYLPVTVVNT | 
    100:
    TMSLTALRQQ | MQTQNLSAYI | IPGTDAHMNE | YIGQHDERRA | WITGFTGSAG | 
    150:
    TAVVTMKKAA | VWTDSRYWTQ | AERQMDCNWE | LHKEVGTTPI | VTWLLTEIPA | 
    200:
    GGRVGFDPFL | LSIDTWESYD | LALQGSNRQL | VSITTNLVDL | VWGSERPPVP | 
    250:
    NQPIYALQEA | FTGSTWQEKV | SGVRSQMQKH | QKVPTAVLLS | ALEETAWLFN | 
    300:
    LRASDIPYNP | FFYSYTLLTD | SSIRLFANKS | RFSSETLSYL | NSSCTGPMCV | 
    350:
    QIEDYSQVRD | SIQAYSLGDV | RIWIGTSYTM | YGIYEMIPKE | KLVTDTYSPV | 
    400:
    MMTKAVKNSK | EQALLKASHV | RDAVAVIRYL | VWLEKNVPKG | TVDEFSGAEI | 
    450:
    VDKFRGEEQF | SSGPSFETIS | ASGLNAALAH | YSPTKELNRK | LSSDEMYLLD | 
    500:
    SGGQYWDGTT | DITRTVHWGT | PSAFQKEAYT | RVLIGNIDLS | RLIFPAATSG | 
    550:
    RMVEAFARRA | LWDAGLNYGH | GTGHGIGNFL | CVHEWPVGFQ | SNNIAMAKGM | 
    600:
    FTSIEPGYYK | DGEFGIRLED | VALVVEAKTK | YPGSYLTFEV | VSFVPYDRNL | 
    650:
    IDVSLLSPEH | LQYLNRYYQT | IREKVGPELQ | RRQLLEEFEW | LQQHTEPLAA | 
    674:
    RAPDTASWAS | VLVVSTLAIL | GWSV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    SMR:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Xaa-Pro aminopeptidase 2
    ELISA Kit for Human Xaa-Pro aminopeptidase 2
    CLIA Kit for Human Xaa-Pro aminopeptidase 2
    CLIA Kit for Human Xaa-Pro aminopeptidase 2
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 2
    Polyclonal Antibody for Human Xaa-Pro aminopeptidase 2
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 2
    Monoclonal Antibody for Human Xaa-Pro aminopeptidase 2
    Protein for Human Xaa-Pro aminopeptidase 2
    Protein for Human Xaa-Pro aminopeptidase 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and tissue distribution of human membrane-bound aminopeptidase P."
      Venema R.C. , Ju H. , Zou R. , Venema V.J. , Ryan J.W.
      Biochim. Biophys. Acta1354:45-48(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Kidney.
      tissue: Lung.
    2. 2.
      Sprinkle T.J.C. , Venema R.C. , Ju H. , Zou R. , Venema V.J. , Ryan J.W.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Human membrane-bound aminopeptidase P genomic DNA."
      Ryan J.W. , Jin L. , Horvath I. , Sprinkle T.J.C.
      Submitted (1999-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AEACEI
    7. 7.
      "Sex-dependent and race-dependent association of XPNPEP2 C-2399A polymorphism with angiotensin-converting enzyme inhibitor-associated angioedema."
      Woodard-Grice A.V. , Lucisano A.C. , Byrd J.B. , Stone E.R. , Simmons W.H. , Brown N.J.
      Pharmacogenet. Genomics20:532-536(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AEACEI
    8. 8.
      "A functional XPNPEP2 promoter haplotype leads to reduced plasma aminopeptidase P and increased risk of ACE inhibitor-induced angioedema."
      Cilia La Corte A.L. , Carter A.M. , Rice G.I. , Duan Q.L. , Rouleau G.A. , Adam A. , Grant P.J. , Hooper N.M.
      Hum. Mutat.32:1326-1331(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AEACEI;VARIANTS ILE-215; ILE-223 AND ASN-232
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