XRCC3 ELISA Kit for Human(Homo sapiens) | EIAab.comXRCC3 ELISA Kit for Human(Homo sapiens)

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XRCC3 (Gene name),

DNA repair protein XRCC3 (Protein name ), XRCC3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

XRCC3;

Protein name:

DNA repair protein XRCC3;

Alternative:

X-ray repair cross-complementing protein 3;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG.

Function:

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.

Subcellular Location:

Nucleus Cytoplasm Cytoplasm perinuclear region Mitochondrion Accumulates in discrete nuclear foci prior to DNA damage, and these foci persist throughout the time course of DNA repair.

Protein Attributes:

Sequence length:

346

Sequence:

50:

100:

150:

200:

250:

300:

346:

LREEEAALGC | PARTLRVLSA | PHLPPSSCSY | TISAEGVRGT | PGTQSH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O43542

Pfam:

PF08423

UniGene:

Hs.592325

SMR:

O43542

KEGG:

hsa:7517

STRING:

9606.ENSP00000343392

MIM:

114480

Uniprot:

O43542

FOR

ELISA Kit for Human DNA repair protein XRCC3

CLIA Kit for Human DNA repair protein XRCC3

Polyclonal Antibody for Human DNA repair protein XRCC3

Monoclonal Antibody for Human DNA repair protein XRCC3

Protein for Human DNA repair protein XRCC3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages."
Liu N. , Lamerdin J.E. , Tebbs R.S. , Schild D. , Tucker J.D. , Shen M.R. , Brookman K.W. , Siciliano M.J. , Walter C.A. , Fan W. , Narayana L.S. , Zhou Z.-Q. , Adamson A.W. , Sorensen K.J. , Chen D.J. , Jones N.J. , Thompson L.H.
Mol. Cell1:783-793(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT MET-241
tissue: Cervix carcinoma.
2.

NIEHS SNPs program
Submitted (2002-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-94 AND MET-241
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lymph.
tissue: Muscle.
tissue: Placenta.
4.

"Identification and purification of two distinct complexes containing the five RAD51 paralogs."
Masson J.Y. , Tarsounas M.C. , Stasiak A.Z. , Stasiak A. , Shah R. , McIlwraith M.J. , Benson F.E. , West S.C.
Genes Dev.15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CX3 COMPLEX WITH XRCC3
5.

"Variants in DNA double-strand break repair genes and breast cancer susceptibility."
Kuschel B. , Auranen A. , McBride S. , Novik K.L. , Antoniou A. , Lipscombe J.M. , Day N.E. , Easton D.F. , Ponder B.A. , Pharoah P.D. , Dunning A.
Hum. Mol. Genet.11:1399-1407(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BC SUSCEPTIBILITY
6.

"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."
Miller K.A. , Yoshikawa D.M. , McConnell I.R. , Clark R. , Schild D. , Albala J.S.
J. Biol. Chem.277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE CX3 COMPLEX WITH XRCC3
7.

"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."
Liu N. , Schild D. , Thelen M.P. , Thompson L.H.
Nucleic Acids Res.30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51 AND RAD51C
8.

"Domain mapping of the Rad51 paralog protein complexes."
Miller K.A. , Sawicka D. , Barsky D. , Albala J.S.
Nucleic Acids Res.32:169-178(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51C
9.

"RAD51C is required for Holliday junction processing in mammalian cells."
Liu Y. , Masson J.Y. , Shah R. , O'Regan P. , West S.C.
Science303:243-246(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51."
Bennett B.T. , Knight K.L.
J. Cell. Biochem.96:1095-1109(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
11.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
12.

"Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome."
Sage J.M. , Gildemeister O.S. , Knight K.L.
J. Biol. Chem.285:18984-18990(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION
13.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."
Liu T. , Wan L. , Wu Y. , Chen J. , Huang J.
J. Biol. Chem.286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SWSAP1 AND ZSWIM7
15.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."
Rodrigue A. , Coulombe Y. , Jacquet K. , Gagne J.P. , Roques C. , Gobeil S. , Poirier G. , Masson J.Y.
J. Cell Sci.126:348-359(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HOLLIDAY JUNCTION RESOLUTION
17.

"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."
Chun J. , Buechelmaier E.S. , Powell S.N.
Mol. Cell. Biol.33:387-395(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE CX3 COMPLEX
18.

"Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair."
Park J.Y. , Singh T.R. , Nassar N. , Zhang F. , Freund M. , Hanenberg H. , Meetei A.R. , Andreassen P.R.
Oncogene33:4803-4812(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PALB2;IDENTIFICATION IN A PALB2-CONTAINING HR COMPLEX
19.

"Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."
Compton S.A. , Ozgur S. , Griffith J.D.
J. Biol. Chem.285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON MICROSCOPY OF THE CX3 COMPLEX;DNA-BINDING OF THE CX3 COMPLEX
20.

"A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer."
Winsey S.L. , Haldar N.A. , Marsh H.P. , Bunce M. , Marshall S.E. , Harris A.L. , Wojnarowska F. , Welsh K.I.
Cancer Res.60:5612-5616(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CMM6 SUSCEPTIBILITY MET-241

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