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Index > Protein center > Xrcc4(Gene name) > Mouse
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  • Xrcc4 (Gene name),
  • DNA repair protein XRCC4 (Protein name ),  XRCC4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Xrcc4;
    Protein name:
    DNA repair protein XRCC4;
    Alternative:
    X-ray repair cross-complementing protein 4;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homodimer and homotetramer in solution. The homodimer associates with LIG4, and the LIG4-XRCC4 complex associates in a DNA-dependent manner with the DNA-PK complex formed by the Ku p70/p86 dimer (XRCC6/XRCC5) and PRKDC. Seems to interact directly with PRKDC but not with the Ku p70/86 dimer. Interacts with XLF/Cernunnos. Interacts with APTX and APLF.
    Function:
    Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    326
    Sequence:
    50:
    MERKVSRIYL | ASEPNVPYFL | QVSWERAIGS | GFVITLTDGH | SAWTATVSEL | 
    100:
    EISQEADDMA | MEKGKYIDEL | RKALVPGSGA | AGTYKFLFSK | ESQHFSLEKE | 
    150:
    LKDVSFRLGS | FNLDKVSNSA | EVIRELICYC | LDTITEKQAK | NEHLQKENER | 
    200:
    LLRDWNDVQG | RFEKCVSAKE | ALEADLYQRF | ILVLNEKKTK | IRSLHKLLNE | 
    250:
    VQQLEESTKP | ERENPCSDKT | PEEHGLYDGS | TDEESGAPVQ | AAETLHKDDS | 
    300:
    IFSSPDVTDI | APSRKRRHRM | QKNLGTEPKM | APQELPLQEK | ERLASSLPQT | 
    326:
    LKEESTSAEN | MSLETLRNSS | PEDLFD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse DNA repair protein XRCC4
    ELISA Kit for Mouse DNA repair protein XRCC4
    CLIA Kit for Mouse DNA repair protein XRCC4
    CLIA Kit for Mouse DNA repair protein XRCC4
    Polyclonal Antibody for Mouse DNA repair protein XRCC4
    Polyclonal Antibody for Mouse DNA repair protein XRCC4
    Monoclonal Antibody for Mouse DNA repair protein XRCC4
    Monoclonal Antibody for Mouse DNA repair protein XRCC4
    Protein for Mouse DNA repair protein XRCC4
    Protein for Mouse DNA repair protein XRCC4

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Molecular characterization of ionizing radiation-hypersensitive mutant M10 cells."
      Mori M. , Itsukaichi H. , Nakamura A. , Sato K.
      Mutat. Res.487:85-92(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Eye.
      tissue: Thymus.
      tissue: Tongue.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Mammary tumor.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
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