APP ELISA Kit for Human(Homo sapiens) | EIAab.comAPP ELISA Kit for Human(Homo sapiens)

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APP (Gene name),

Amyloid beta A4 protein (Protein name ), A4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

APP(A4;AD1);

Protein name:

Amyloid beta A4 protein;

Alternative:

APPI(APP);ABPP;Cerebral vascular amyloid peptide(CVAP);Alzheimer disease amyloid protein;Protease nexin-II(PN-II);PreA4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1 and, NUMB and DAB1 (By similarity). Binding to DAB1 inhibits its serine phosphorylation (By similarity). Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains) (By similarity), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. Soluble APP binds, via its N-terminal head, to FBLN1. Interacts with CPEB1 and AGER (By similarity). Interacts with ANKS1B and TNFRSF21. Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Function:

N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Subcellular Location:

Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FRPL1 at the cell surface and the complex is then rapidly internalized. APP sorts to the basolateral surface in epithelial cells. During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment.

Protein Attributes:

Sequence length:

770

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

770:

KMQQNGYENP | TYKFFEQMQN |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P05067

Pfam:

PF10515

MIM:

104300

String:

P05067

KEGG:

hsa:351

UniGene:

Hs.434980

Uniprot:

P05067

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ELISA Kit for Human Amyloid beta A4 protein

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E0946h

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96T

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ELISA Kit for Human Amyloid beta A4 protein

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E0946m

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ELISA Kit for Human Amyloid beta A4 protein

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E0946r

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ELISA Kit for Human Amyloid beta A4 protein

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ELISA Kit for Human Amyloid beta A4 protein

MSDS:

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ELISA Kit for Human Amyloid beta A4 protein

MSDS:

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ELISA Kit for Human Amyloid beta A4 protein

Cat.:

E0946p

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96T

CLIA Kit for Human Amyloid beta A4 protein

Cat.:

U0946m

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Packing:

96T

CLIA Kit for Human Amyloid beta A4 protein

Cat.:

U0946p

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Packing:

96T

CLIA Kit for Human Amyloid beta A4 protein

MSDS:

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CLIA Kit for Human Amyloid beta A4 protein

MSDS:

Please sign in first.

CLIA Kit for Human Amyloid beta A4 protein

MSDS:

Please sign in first.

CLIA Kit for Human Amyloid beta A4 protein

Cat.:

U0946r

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Amyloid beta A4 protein

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U0946h

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Polyclonal Antibody for Human Amyloid beta A4 protein

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P0946Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Amyloid beta A4 protein

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P0946Rb-r

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Polyclonal Antibody for Human Amyloid beta A4 protein

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P0946Rb-m

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Polyclonal Antibody for Human Amyloid beta A4 protein

Monoclonal Antibody for Human Amyloid beta A4 protein

Protein for Human Amyloid beta A4 protein

Cat.:

R0946h

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Packing:

1mg

Purity:

>90%

Protein for Human Amyloid beta A4 protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"Pentosidine determination in CSF: a potential biomarker of Alzheimer’s disease?"

F Monacelli, R Borghi, D Pacini, et al.

From:Clinical Chemistry and Laboratory Medicine

References

1.

"The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor."
Kang J. , Lemaire H.-G. , Unterbeck A. , Salbaum J.M. , Masters C.L. , Grzeschik K.-H. , Multhaup G. , Beyreuther K. , Mueller-Hill B.
Nature325:733-736(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695)
tissue: Brain.
2.

"A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors."
Ponte P. , Gonzalez-Dewhitt P. , Schilling J. , Miller J. , Hsu D. , Greenberg B. , Davis K. , Wallace W. , Lieberburg I. , Fuller F. , Cordell B.
Nature331:525-527(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP751)
tissue: Brain.
3.

"The PreA4(695) precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons."
Lemaire H.-G. , Salbaum J.M. , Multhaup G. , Kang J. , Bayney R.M. , Unterbeck A. , Beyreuther K. , Mueller-Hill B.
Nucleic Acids Res.17:517-522(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP695)
4.

"Genomic organization of the human amyloid beta-protein precursor gene."
Yoshikai S. , Sasaki H. , Doh-ura K. , Furuya H. , Sakaki Y.
Gene87:257-263(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770)
5.

Yoshikai S. , Sasaki H. , Doh-ura K. , Furuya H. , Sakaki Y.
Gene102:291-292(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
6.

"Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells."
Koenig G. , Moenning U. , Czech C. , Prior R. , Banati R. , Schreiter-Gasser U. , Bauer J. , Masters C.L. , Beyreuther K.
J. Biol. Chem.267:10804-10809(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM L-APP733)
tissue: Leukocyte.
7.

"A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus."
Hattori M. , Tsukahara F. , Furuhata Y. , Tanahashi H. , Hirose M. , Saito M. , Tsukuni S. , Sakaki Y.
Nucleic Acids Res.25:1802-1808(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM APP770)
8.

"Identification of a novel alternative splicing isoform of human amyloid precursor protein gene, APP639."
Tang K. , Wang C. , Shen C. , Sheng S. , Ravid R. , Jing N.
Eur. J. Neurosci.18:102-108(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP639);TISSUE SPECIFICITY
tissue: Brain.
9.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS APP770 AND 11)
tissue: Cerebellum.
tissue: Hippocampus.
10.

NIEHS SNPs program
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-501
11.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS APP305 AND APP751)
tissue: Eye.
tissue: Pancreas.
14.

"A cDNA specifying the human amyloid beta precursor protein (ABPP) encodes a 95-kDa polypeptide."
Schon E.A. , Mita S. , Sadlock J. , Herbert J.
Nucleic Acids Res.16:9351-9351(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-10
tissue: Liver.
15.

Schon E.A. , Mita S. , Sadlock J. , Herbert J.
Nucleic Acids Res.16:11402-11402(1988)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;SEQUENCE REVISION
16.

"Characterization of the 5'-end region and the first two exons of the beta-protein precursor gene."
La Fauci G. , Lahiri D.K. , Salton S.R. , Robakis N.K.
Biochem. Biophys. Res. Commun.159:297-304(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-75
17.

"Purification of protease nexin II from human fibroblasts."
van Nostrand W.E. , Cunningham D.D.
J. Biol. Chem.262:8508-8514(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-50
tissue: Fibroblast.
18.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-40
tissue: Platelet.
19.

"Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease."
Tanzi R.E. , McClatchey A.I. , Lamperti E.D. , Villa-Komaroff L. , Gusella J.F. , Neve R.L.
Nature331:528-530(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 286-366
20.

"Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity."
Kitaguchi N. , Takahashi Y. , Tokushima Y. , Shiojiri S. , Ito H.
Nature331:530-532(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 287-367
21.

"Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex."
Zain S.B. , Salim M. , Chou W.G. , Sajdel-Sulkowska E.M. , Majocha R.E. , Marotta C.A.
Proc. Natl. Acad. Sci. U.S.A.85:929-933(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 507-770
tissue: Brain cortex.
22.

"Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I."
Beher D. , Hesse L. , Masters C.L. , Multhaup G.
J. Biol. Chem.271:1613-1620(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 523-555;DOMAIN COLLAGEN-BINDING
23.

"A system for studying the effect(s) of familial Alzheimer disease mutations on the processing of the beta-amyloid peptide precursor."
Denman R.B. , Rosenzcwaig R. , Miller D.L.
Biochem. Biophys. Res. Commun.192:96-103(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 655-737;VARIANTS AD1 GLY-717; ILE-717 AND PHE-717
24.

"Alzheimer's disease amyloid peptide is encoded by two exons and shows similarity to soybean trypsin inhibitor."
Johnstone E.M. , Chaney M.O. , Moore R.E. , Ward K.E. , Norris F.H. , Little S.P.
Biochem. Biophys. Res. Commun.163:1248-1255(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 656-737
25.

"Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease."
Wakutani Y. , Watanabe K. , Adachi Y. , Wada-Isoe K. , Urakami K. , Ninomiya H. , Saido T.C. , Hashimoto T. , Iwatsubo T. , Nakashima K.
J. Neurol. Neurosurg. Psych.75:1039-1042(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 672-723;VARIANT AD1 ASN-678
26.

"Beta-amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease."
Roher A.E. , Lowenson J.D. , Clarke S. , Woods A.S. , Cotter R.J. , Gowing E. , Ball M.J.
Proc. Natl. Acad. Sci. U.S.A.90:10836-10840(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-713
tissue: Blood vessel.
27.

"Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids."
Seubert P. , Vigo-Pelfrey C. , Esch F. , Lee M. , Dovey H. , Davis D. , Sinha S. , Schlossmacher M. , Whaley J. , Swindlehurst C.
Nature359:325-327(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-704;TISSUE SPECIFICITY
28.

"The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient."
Wisniewski T. , Lalowski M. , Levy E. , Marques M.R.F. , Frangione B.
Ann. Neurol.35:245-246(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-701 AND 707-713
29.

"Characterization of beta-amyloid peptide from human cerebrospinal fluid."
Vigo-Pelfrey C. , Lee D. , Keim P. , Lieberburg I. , Schenk D.B.
J. Neurochem.61:1965-1968(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-701
tissue: Cerebrospinal fluid.
30.

"Amyloid angiopathy of Alzheimer's disease: amino acid composition and partial sequence of a 4,200-dalton peptide isolated from cortical microvessels."
Pardridge W.M. , Vinters H.V. , Yang J. , Eisenberg J. , Choi T.B. , Tourtellotte W.W. , Huebner V. , Shively J.E.
J. Neurochem.49:1394-1401(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-681
tissue: Brain cortex.
31.

"Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease."
Goldgaber D. , Lerman M.I. , McBride O.W. , Saffiotti U. , Gajdusek D.C.
Science235:877-880(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 674-770
tissue: Brain.
32.

"Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus."
Tanzi R.E. , Gusella J.F. , Watkins P.C. , Bruns G.A. , St George-Hyslop P.H. , Van Keuren M.L. , Patterson D. , Pagan S. , Kurnit D.M. , Neve R.L.
Science235:880-884(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 674-703
tissue: Fetal brain.
33.

"An online nano-LC-ESI-FTICR-MS method for comprehensive characterization of endogenous fragments from amyloid beta and amyloid precursor protein in human and cat cerebrospinal fluid."
Brinkmalm G. , Portelius E. , Ohrfelt A. , Mattsson N. , Persson R. , Gustavsson M.K. , Vite C.H. , Gobom J. , Mansson J.E. , Nilsson J. , Halim A. , Larson G. , Ruetschi U. , Zetterberg H. , Blennow K. , Brinkmalm A.
J. Mass Spectrom.47:591-603(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 609-713;GLYCOSYLATION AT SER-614; SER-623; SER-628; SER-679 AND SER-697
tissue: Cerebrospinal fluid.
34.

"BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimer's disease in Down syndrome."
Sun X. , He G. , Song W.
FASEB J.20:1369-1376(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 691-698;CLEAVAGE BY THETA-SECRETASE
35.

"A novel mRNA of the A4 amyloid precursor gene coding for a possibly secreted protein."
de Sauvage F. , Octave J.-N.
Science245:651-653(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP751)
tissue: Brain.
36.

"Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides."
Robakis N.K. , Ramakrishna N. , Wolfe G. , Wisniewski H.M.
Proc. Natl. Acad. Sci. U.S.A.84:4190-4194(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695)
tissue: Brain.
37.

"The chondroitin sulfate attachment site of appican is formed by splicing out exon 15 of the amyloid precursor gene."
Pangalos M.N. , Efthimiopoulos S. , Shioi J. , Robakis N.K.
J. Biol. Chem.270:10388-10391(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF L-APP733;MUTAGENESIS OF SER-656
38.

"Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions."
Walter M.F. , Mason P.E. , Mason R.P.
Biochem. Biophys. Res. Commun.233:760-764(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF BETA-AMYLOID PEPTIDE AS LIPID PEROXIDATION INHIBITOR;MUTAGENESIS OF MET-706
39.

"Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins."
Kontush A.
Cell. Mol. Neurobiol.21:299-315(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION OF BETA-AMYLOID AS ANTIOXIDANT
40.

"The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II."
Oltersdorf T. , Fritz L.C. , Schenk D.B. , Lieberburg I. , Johnson-Wood K.L. , Beattie E.C. , Ward P.J. , Blacher R.W. , Dovey H.F. , Sinha S.
Nature341:144-147(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTITY OF APP WITH NEXIN-II
41.

"Protease-specificity of Kunitz inhibitor domain of Alzheimer's disease amyloid protein precursor."
Kido H. , Fukutomi A. , Schilling J. , Wang Y. , Cordell B. , Katunuma N.
Biochem. Biophys. Res. Commun.167:716-721(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEASE-SPECIFICITY OF INHIBITOR DOMAIN
42.

"A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease."
Bush A.I. , Multhaup G. , Moir R.D. , Williamson T.G. , Small D.H. , Rumble B. , Pollwein P. , Beyreuther K. , Masters C.L.
J. Biol. Chem.268:16109-16112(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EXTRACELLULAR ZINC-BINDING DOMAIN
43.

"Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)."
Nishimoto I. , Okamoto T. , Matsuura Y. , Takahashi S. , Okamoto T. , Murayama Y. , Ogata E.
Nature362:75-79(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH G(O)
44.

"The beta A4 amyloid precursor protein binding to copper."
Hesse L. , Beher D. , Masters C.L. , Multhaup G.
FEBS Lett.349:109-116(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EXTRACELLULAR COPPER-BINDING DOMAIN;MUTAGENESIS OF HIS-137; MET-141; CYS-144; HIS-147 AND HIS-151
45.

"A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth."
Small D.H. , Nurcombe V. , Reed G. , Clarris H. , Moir R. , Beyreuther K. , Masters C.L.
J. Neurosci.14:2117-2127(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: N-TERMINAL HEPARIN-BINDING DOMAIN;MUTAGENESIS OF 99-LYS--ARG-102
46.

"Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43)."
Maruyama K. , Tomita T. , Shinozaki K. , Kume H. , Asada H. , Saido T.C. , Ishiura S. , Iwatsubo T. , Obata K.
Biochem. Biophys. Res. Commun.227:730-735(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF VAL-717
47.

"APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein."
Chow N. , Korenberg J.R. , Chen X.-N. , Neve R.L.
J. Biol. Chem.271:11339-11346(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP-BP1
48.

"The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein."
Borg J.-P. , Ooi J. , Levy E. , Margolis B.
Mol. Cell. Biol.16:6229-6241(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBA1 AND APBB1;MUTAGENESIS OF TYR-728; TYR-757; ASN-759 AND TYR-762
49.

"Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein."
Guenette S.Y. , Chen J. , Jondro P.D. , Tanzi R.E.
Proc. Natl. Acad. Sci. U.S.A.93:10832-10837(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBB2
50.

"Expression and analysis of heparin-binding regions of the amyloid precursor protein of Alzheimer's disease."
Mok S.S. , Sberna G. , Heffernan D. , Cappai R. , Galatis D. , Clarris H.J. , Sawyer W.H. , Beyreuther K. , Masters C.L. , Small D.H.
FEBS Lett.415:303-307(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEPARIN-BINDING DOMAINS
51.

"An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease."
Yan S.D. , Fu J. , Soto C. , Chen X. , Zhu H. , Al-Mohanna F. , Collinson K. , Zhu A. , Stern E. , Saido T. , Tohyama M. , Ogawa S. , Roher A. , Stern D.
Nature389:689-695(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION OF BETA-AMYLOID PEPTIDE WITH HADH2
tissue: Brain.
52.

"PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein."
Zheng P. , Eastman J. , Vande Pol S. , Pimplikar S.W.
Proc. Natl. Acad. Sci. U.S.A.95:14745-14750(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APPBP2;MUTAGENESIS OF TYR-728
53.

"Histidine-13 is a crucial residue in the zinc ion-induced aggregation of the A beta peptide of Alzheimer's disease."
Liu S.T. , Howlett G. , Barrow C.J.
Biochemistry38:9373-9378(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BETA-AMYLOID ZINC-BINDING;MUTAGENESIS OF ARG-676; TYR-681 AND HIS-684
54.

"Methionine residue 35 is important in amyloid beta-peptide-associated free radical oxidative stress."
Varadarajan S. , Yatin S. , Kanski J. , Jahanshahi F. , Butterfield D.A.
Brain Res. Bull.50:133-141(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMPORTANCE OF MET-706 IN FREE RADICAL OXIDATIVE STRESS;MUTAGENESIS OF MET-706
55.

"Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein."
Tomita S. , Ozaki T. , Taru H. , Oguchi S. , Takeda S. , Yagi Y. , Sakiyama S. , Kirino Y. , Suzuki T.
J. Biol. Chem.274:2243-2254(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBA2
56.

"Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42."
Perez R.G. , Soriano S. , Hayes J.D. , Ostaszewski B. , Xia W. , Selkoe D.J. , Chen X. , Stokin G.B. , Koo E.H.
J. Biol. Chem.274:18851-18856(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENDOCYTOSIS SIGNAL;MUTAGENESIS OF TYR-728; GLY-756; TYR-757; ASN-759; PRO-760 AND TYR-762
57.

"Cysteine 144 is a key residue in the copper reduction by the beta-amyloid precursor protein."
Ruiz F.H. , Gonzalez M. , Bodini M. , Opazo C. , Inestrosa N.C.
J. Neurochem.73:1288-1292(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IMPORTANCE OF CYS-144 IN COPPER REDUCTION;MUTAGENESIS OF CYS-144 AND 147-HIS--HIS-149
58.

"Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides."
Tokuda T. , Calero M. , Matsubara E. , Vidal R. , Kumar A. , Permanne B. , Zlokovic B. , Smith J.D. , Ladu M.J. , Rostagno A. , Frangione B. , Ghiso J.
Biochem. J.348:359-365(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION OF BETA-AMYLOID WITH APOE
59.

"Beta-amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology."
Wang H.-Y. , Lee D.H.S. , D'Andrea M.R. , Peterson P.A. , Shank R.P. , Reitz A.B.
J. Biol. Chem.275:5626-5632(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION OF BETA-APP42 WITH CHRNA7
60.

"Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor."
Passer B. , Pellegrini L. , Russo C. , Siegel R.M. , Lenardo M.J. , Schettini G. , Bachmann M. , Tabaton M. , D'Adamio L.
J. Alzheimers Dis.2:289-301(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF GAMMA-CTFS BY MASS SPECTROMETRY;MUTAGENESIS OF ASP-739
61.

"Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages."
Yazawa H. , Yu Z.-X. , Takeda K. , Le Y. , Gong W. , Ferrans V.J. , Oppenheim J.J. , Li C.C.H. , Wang J.M.
FASEB J.15:2454-2462(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FPRL1
62.

"Beta-amyloid peptide-induced apoptosis regulated by a novel protein containing a G protein activation module."
Kajkowski E.M. , Lo C.F. , Ning X. , Walker S. , Sofia H.J. , Wang W. , Edris W. , Chanda P. , Wagner E. , Vile S. , Ryan K. , McHendry-Rinde B. , Smith S.C. , Wood A. , Rhodes K.J. , Kennedy J.D. , Bard J. , Jacobsen J.S. , more...
J. Biol. Chem.276:18748-18756(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BBP
63.

"Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered structure containing superoxide dismutase-like subunits."
Curtain C.C. , Ali F. , Volitakis I. , Cherny R.A. , Norton R.S. , Beyreuther K. , Barrow C.J. , Masters C.L. , Bush A.I. , Barnham K.J.
J. Biol. Chem.276:20466-20473(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BETA-AMYLOID COPPER AND ZINC-BINDING
64.

"Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease."
Scheuermann S. , Hambsch B. , Hesse L. , Stumm J. , Schmidt C. , Beher D. , Bayer T.A. , Beyreuther K. , Multhaup G.
J. Biol. Chem.276:33923-33929(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
65.

"The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner."
Kimberly W.T. , Zheng J.B. , Guenette S.Y. , Selkoe D.J.
J. Biol. Chem.276:40288-40292(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBB1;FUNCTION;SUBCELLULAR LOCATION
66.

"Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function."
Ohsawa I. , Takamura C. , Kohsaka S.
J. Neurochem.76:1411-1420(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBLN1
67.

"Direct interaction of soluble human recombinant tau protein with Abeta 1-42 results in tau aggregation and hyperphosphorylation by tau protein kinase II."
Rank K.B. , Pauley A.M. , Bhattacharya K. , Wang Z. , Evans D.B. , Fleck T.J. , Johnston J.A. , Sharma S.K.
FEBS Lett.514:263-268(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPT;FUNCTION
68.

"Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)."
Scheinfeld M.H. , Roncarati R. , Vito P. , Lopez P.A. , Abdallah M. , D'Adamio L.
J. Biol. Chem.277:3767-3775(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8IP1;MUTAGENESIS OF TYR-757
69.

"Contrasting species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein."
White A.R. , Multhaup G. , Galatis D. , McKinstry W.J. , Parker M.W. , Pipkorn R. , Beyreuther K. , Masters C.L. , Cappai R.
J. Neurosci.22:365-376(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COPPER-MEDIATED LIPID PEROXIDATION;MUTAGENESIS OF HIS-147 AND HIS-151
70.

"The galvanization of beta-amyloid in Alzheimer's disease."
Bush A.I. , Tanzi R.E.
Proc. Natl. Acad. Sci. U.S.A.99:7317-7319(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ZINC-BINDING
71.

"Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease."
Watanabe N. , Araki W. , Chui D.H. , Makifuchi T. , Ihara Y. , Tabira T.
FASEB J.18:1013-1015(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;ASSOCIATION OF AMYLOID FIBRILS WITH GCP1
72.

"Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner."
Ghersi E. , Noviello C. , D'Adamio L.
J. Biol. Chem.279:49105-49112(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANKS1B
73.

"Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein."
Suzuki T. , Oishi M. , Marshak D.R. , Czernik A.J. , Nairn A.C. , Greengard P.
EMBO J.13:1114-1122(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-743
74.

"Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations."
Walter J. , Capell A. , Hung A.Y. , Langen H. , Schnoelzer M. , Thinakaran G. , Sisodia S.S. , Selkoe D.J. , Haass C.
J. Biol. Chem.272:1896-1903(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-198 AND SER-206 BY CASEIN KINASES;MUTAGENESIS OF SER-198 AND SER-206
75.

"Copper-binding amyloid precursor protein undergoes a site-specific fragmentation in the reduction of hydrogen peroxide."
Multhaup G. , Ruppert T. , Schlicksupp A. , Hesse L. , Bill E. , Pipkorn R. , Masters C.L. , Beyreuther K.
Biochemistry37:7224-7230(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COPPER-BINDING;DISULFIDE BOND FORMATION
76.

"Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation."
Gervais F.G. , Xu D. , Robertson G.S. , Vaillancourt J.P. , Zhu Y. , Huang J. , LeBlanc A. , Smith D. , Rigby M. , Shearman M.S. , Clarke E.E. , Zheng H. , van der Ploeg L.H.T. , Ruffolo S.C. , Thornberry N.A. , Xanthoudakis S. , Zamboni R.J. , Roy S. , more...
Cell97:395-406(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY CASPASES;MUTAGENESIS OF ASP-739
77.

"Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation."
Ando K. , Oishi M. , Takeda S. , Iijima K. , Isohara T. , Nairn A.C. , Kirino Y. , Greengard P. , Suzuki T.
J. Neurosci.19:4421-4427(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;MUTAGENESIS OF THR-743
78.

"Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2."
Walter J. , Schindzielorz A. , Hartung B. , Haass C.
J. Biol. Chem.275:23523-23529(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF CASEIN KINASE PHOSPHORYLATION;MUTAGENESIS OF SER-198 AND SER-206
79.

"A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor."
Lu D.C. , Rabizadeh S. , Chandra S. , Shayya R.F. , Ellerby L.M. , Ye X. , Salvesen G.S. , Koo E.H. , Bredesen D.E.
Nat. Med.6:397-404(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY CASPASES;MUTAGENESIS OF ASP-739
80.

"Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid."
Ando K. , Iijima K. , Elliott J.I. , Kirino Y. , Suzuki T.
J. Biol. Chem.276:40353-40361(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH APBB1;MUTAGENESIS OF THR-743
81.

"Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)."
Standen C.L. , Brownlees J. , Grierson A.J. , Kesavapany S. , Lau K.-F. , McLoughlin D.M. , Miller C.C.J.
J. Neurochem.76:316-320(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAPK10;MUTAGENESIS OF THR-743
82.

"A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing."
Weidemann A. , Eggert S. , Reinhard F.B.M. , Vogel M. , Paliga K. , Baier G. , Masters C.L. , Beyreuther K. , Evin G.
Biochemistry41:2825-2835(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE AT LEU-720
83.

"Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc."
Tarr P.E. , Roncarati R. , Pelicci G. , Pelicci P.G. , D'Adamio L.
J. Biol. Chem.277:16798-16804(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-757;INTERACTION WITH SHC1;MUTAGENESIS OF THR-743 AND TYR-757
84.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-542
tissue: Plasma.
85.

"Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease."
Dyrks T. , Weidemann A. , Multhaup G. , Salbaum J.M. , Lemaire H.-G. , Kang J. , Mueller-Hill B. , Masters C.L. , Beyreuther K.
EMBO J.7:949-957(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIGNAL SEQUENCE CLEAVAGE SITE;TOPOLOGY
86.

"A cell biological perspective on Alzheimer's disease."
Annaert W. , De Strooper B.
Annu. Rev. Cell Dev. Biol.18:25-51(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
87.

"Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein."
Andersen O.M. , Reiche J. , Schmidt V. , Gotthardt M. , Spoelgen R. , Behlke J. , von Arnim C.A. , Breiderhoff T. , Jansen P. , Wu X. , Bales K.R. , Cappai R. , Masters C.L. , Gliemann J. , Mufson E.J. , Hyman B.T. , Paul S.M. , Nykjaer A. , more...
Proc. Natl. Acad. Sci. U.S.A.102:13461-13466(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SORL1;SUBCELLULAR LOCATION
88.

"Regulation of FE65 nuclear translocation and function by amyloid beta-protein precursor in osmotically stressed cells."
Nakaya T. , Kawai T. , Suzuki T.
J. Biol. Chem.283:19119-19131(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APBB1
89.

"BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2."
Matsuda S. , Matsuda Y. , D'Adamio L.
J. Biol. Chem.284:15815-15825(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITM2C
90.

"APP binds DR6 to trigger axon pruning and neuron death via distinct caspases."
Nikolaev A. , McLaughlin T. , O'Leary D.D.M. , Tessier-Lavigne M.
Nature457:981-989(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CLEAVAGE;INTERACTION WITH TNFRSF21
91.

"RAGE-mediated signaling contributes to intraneuronal transport of amyloid-{beta} and neuronal dysfunction."
Takuma K. , Fang F. , Zhang W. , Yan S. , Fukuzaki E. , Du H. , Sosunov A. , McKhann G. , Funatsu Y. , Nakamichi N. , Nagai T. , Mizoguchi H. , Ibi D. , Hori O. , Ogawa S. , Stern D.M. , Yamada K. , Yan S.S.
Proc. Natl. Acad. Sci. U.S.A.106:20021-20026(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AGER
92.

"Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease."
He G. , Luo W. , Li P. , Remmers C. , Netzer W.J. , Hendrick J. , Bettayeb K. , Flajolet M. , Gorelick F. , Wennogle L.P. , Greengard P.
Nature467:95-98(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GSAP
93.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
94.

"Site-specific characterization of threonine, serine, and tyrosine glycosylations of amyloid precursor protein/amyloid beta-peptides in human cerebrospinal fluid."
Halim A. , Brinkmalm G. , Ruetschi U. , Westman-Brinkmalm A. , Portelius E. , Zetterberg H. , Blennow K. , Larson G. , Nilsson J.
Proc. Natl. Acad. Sci. U.S.A.108:11848-11853(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-633; THR-651; THR-652; SER-656; THR-663 AND SER-667 PROTEOLYTIC PROCESSING;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
95.

"MRP14 (S100A9) protein interacts with Alzheimer beta-amyloid peptide and induces its fibrillization."
Zhang C. , Liu Y. , Gilthorpe J. , van der Maarel J.R.
PLoS ONE7:E32953-E32953(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH S100A9
96.

"Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease."
UK Brain Expression Consortium , Cruchaga C. , Karch C.M. , Jin S.C. , Benitez B.A. , Cai Y. , Guerreiro R. , Harari O. , Norton J. , Budde J. , Bertelsen S. , Jeng A.T. , Cooper B. , Skorupa T. , Carrell D. , Levitch D. , Hsu S. , Choi J. , more...
Nature505:550-554(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLD3
97.

"X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor."
Hynes T.R. , Randal M. , Kennedy L.A. , Eigenbrot C. , Kossiakof A.A.
Biochemistry29:10018-10022(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 287-344
98.

"Sequential NMR resonance assignment and structure determination of the Kunitz-type inhibitor domain of the Alzheimer's beta-amyloid precursor protein."
Heald S.L. , Tilton R.F. Jr. , Hammond L.S. , Lee A. , Bayney R.M. , Kamarck M.E. , Ramabhadran T.V. , Dreyer R.N. , Davis G. , Unterbeck A. , Tamburini P.P.
Biochemistry30:10467-10478(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 289-344
99.

"Solution structure of residues 1-28 of the amyloid beta-peptide."
Talafous J. , Marcinowski K.J. , Klopman G. , Zagorski M.G.
Biochemistry33:7788-7796(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 672-699
100.

"Structure of amyloid A4-(1-40)-peptide of Alzheimer's disease."
Sticht H. , Bayer P. , Willbold D. , Dames S. , Hilbich C. , Beyreuther K. , Frank R.W. , Rosch P.
Eur. J. Biochem.233:293-298(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 672-711
101.

"Three-dimensional structures of the amyloid beta peptide (25-35) in membrane-mimicking environment."
Kohno T. , Kobayashi K. , Maeda T. , Sato K. , Takashima A.
Biochemistry35:16094-16104(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 696-706
102.

"Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities."
Scheidig A.J. , Hynes T.R. , Pelletier L.A. , Wells J.A. , Kossiakoff A.A.
Protein Sci.6:1806-1824(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF KUNITZ DOMAIN IN COMPLEX WITH CHYMOTRYPSIN; TRYPSIN AND BASIC PANCREATIC TRYPSIN INHIBITOR
103.

"Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is?"
Coles M. , Bicknell W. , Watson A.A. , Fairlie D.P. , Craik D.J.
Biochemistry37:11064-11077(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 672-711
104.

"Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein."
Rossjohn J. , Cappai R. , Feil S.C. , Henry A. , McKinstry W.J. , Galatis D. , Hesse L. , Multhaup G. , Beyreuther K. , Masters C.L. , Parker M.W.
Nat. Struct. Biol.6:327-331(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 28-123
105.

"Substitutions at codon 22 of Alzheimer's Abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells."
Miravalle L. , Tokuda T. , Chiarle R. , Giaccone G. , Bugiani O. , Tagliavini F. , Frangione B. , Ghiso J.
J. Biol. Chem.275:27110-27116(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE OF CAA-APP VARIANTS
106.

"The Alzheimer's peptide a beta adopts a collapsed coil structure in water."
Zhang S. , Iwata K. , Lachenmann M.J. , Peng J.W. , Li S. , Stimson E.R. , Lu Y. , Felix A.M. , Maggio J.E. , Lee J.P.
J. Struct. Biol.130:130-141(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 681-706
107.

"Solution structures in aqueous SDS micelles of two amyloid beta peptides of Abeta(1-28) mutated at the alpha-secretase cleavage site."
Poulsen S.-A. , Watson A.A. , Craik D.J.
J. Struct. Biol.130:142-152(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 672-699
108.

"The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain."
Wang Y. , Ha Y.
Mol. Cell15:343-353(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 346-551;PARTIAL PROTEIN SEQUENCE;MUTAGENESIS OF ARG-499 AND LYS-503;IDENTIFICATION BY MASS SPECTROMETRY
109.

"Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism."
Shen Y. , Joachimiak A. , Rosner M.R. , Tang W.-J.
Nature443:870-874(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 672-711 IN COMPLEX WITH IDE
110.

"Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution."
Kong G.K. , Adams J.J. , Cappai R. , Parker M.W.
Acta Crystallogr. F63:819-824(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.85 ANGSTROMS) OF 133-189;DISULFIDE BONDS
111.

"Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions."
Kong G.K. , Adams J.J. , Harris H.H. , Boas J.F. , Curtain C.C. , Galatis D. , Masters C.L. , Barnham K.J. , McKinstry W.J. , Cappai R. , Parker M.W.
J. Mol. Biol.367:148-161(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 133-189 IN COMPLEXES WITH COPPER IONS;DISULFIDE BONDS
112.

"Molecular basis for passive immunotherapy of Alzheimer's disease."
Gardberg A.S. , Dice L.T. , Ou S. , Rich R.L. , Helmbrecht E. , Ko J. , Wetzel R. , Myszka D.G. , Patterson P.H. , Dealwis C.
Proc. Natl. Acad. Sci. U.S.A.104:15659-15664(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 672-679 IN COMPLEX WITH IGG
113.

"Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease."
Basi G.S. , Feinberg H. , Oshidari F. , Anderson J. , Barbour R. , Baker J. , Comery T.A. , Diep L. , Gill D. , Johnson-Wood K. , Goel A. , Grantcharova K. , Lee M. , Li J. , Partridge A. , Griswold-Prenner I. , Piot N. , Walker D. , more...
J. Biol. Chem.285:3417-3427(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 672-678 IN COMPLEXES WITH ANTIBODY FAB FRAGMENTS
114.

"Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein."
Dahms S.O. , Hoefgen S. , Roeser D. , Schlott B. , Guhrs K.H. , Than M.E.
Proc. Natl. Acad. Sci. U.S.A.107:5381-5386(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 18-190;PARTIAL PROTEIN SEQUENCE;SUBUNIT;DISULFIDE BONDS;IDENTIFICATION BY MASS SPECTROMETRY
115.

"Framing beta-amyloid."
Hardy J.
Nat. Genet.1:233-234(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
116.

"Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type."
Levy E. , Carman M.D. , Fernandez-Madrid I.J. , Power M.D. , Lieberburg I. , van Duinen S.G. , Bots G.T.A.M. , Luyendijk W. , Frangione B.
Science248:1124-1126(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAA-APP GLN-693
117.

"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease."
Goate A. , Chartier-Harlin M.-C. , Mullan M. , Brown J. , Crawford F. , Fidani L. , Giuffra L. , Haynes A. , Irving N. , James L. , Mant R. , Newton P. , Rooke K. , Roques P. , Talbot C. , Pericak-Vance M. , Roses A.D. , Williamson R. , more...
Nature349:704-706(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-717
118.

"The 717Val-->Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups."
Yoshioka K. , Miki T. , Katsuya T. , Ogihara T. , Sakaki Y.
Biochem. Biophys. Res. Commun.178:1141-1146(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-717
119.

"Mis-sense mutation Val->Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease."
Naruse S. , Igarashi S. , Kobayashi H. , Aoki K. , Inuzuka T. , Kaneko K. , Shimizu T. , Iihara K. , Kojima T. , Miyatake T. , Tsuji S.
Lancet337:978-979(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-717
120.

"Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene."
Chartier-Harlin M.-C. , Crawford F. , Houlden H. , Warren A. , Hughes D. , Fidani L. , Goate A. , Rossor M. , Roques P. , Hardy J. , Mullan M.
Nature353:844-846(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 GLY-717
121.

"A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease."
Murrell J.R. , Farlow M. , Ghetti B. , Benson M.D.
Science254:97-99(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 PHE-717
122.

"Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region."
Kamino K. , Orr H.T. , Payami H. , Wijsman E.M. , Alonso M.E. , Pulst S.M. , Anderson L. , O'Dahl S. , Nemens E. , White J.A. , Sadovnick A.D. , Ball M.J. , Kaye J. , Warren A. , McInnis M.G. , Antonarakis S.E. , Korenberg J.R. , Sharma V. , more...
Am. J. Hum. Genet.51:998-1014(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 GLY-693
123.

"Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene."
Hendriks L. , van Duijn C.M. , Cras P. , Cruts M. , Van Hul W. , van Harskamp F. , Warren A. , McInnis M.G. , Antonarakis S.E. , Martin J.J. , Hofman A. , Van Broeckhoven C.
Nat. Genet.1:218-221(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 GLY-692
124.

"A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid."
Mullan M. , Crawford F. , Axelman K. , Houlden H. , Lilius L. , Winblad B. , Lannfelt L.
Nat. Genet.1:345-347(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 670-ASN-LEU-671
125.

"Mutation in codon 713 of the beta amyloid precursor protein gene presenting with schizophrenia."
Jones C.T. , Morris S. , Yates C.M. , Moffoot A. , Sharpe C. , Brock D.J.H. , St Clair D.
Nat. Genet.1:306-309(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-713
126.

"More missense in amyloid gene."
Carter D.A. , Desmarais E. , Bellis M. , Campion D. , Clerget-Darpoux F. , Brice A. , Agid Y. , Jaillard-Serradt A. , Mallet J.
Nat. Genet.2:255-256(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 THR-713
127.

"Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations."
Liepnieks J.J. , Ghetti B. , Farlow M. , Roses A.D. , Benson M.D.
Biochem. Biophys. Res. Commun.197:386-392(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AD1 ILE-717 AND PHE-717
128.

"Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease."
Peacock M.L. , Murman D.L. , Sima A.A.F. , Warren J.T. Jr. , Roses A.D. , Fink J.K.
Ann. Neurol.35:432-438(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASP-665
129.

"Clinical characteristics in a kindred with early-onset Alzheimer's disease and their linkage to a G-->T change at position 2149 of the amyloid precursor protein gene."
Farlow M. , Murrell J. , Ghetti B. , Unverzagt F. , Zeldenrust S. , Benson M.D.
Neurology44:105-111(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 PHE-717
130.

"A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease."
Brooks W.S. , Martins R.N. , De Voecht J. , Nicholson G.A. , Schofield P.R. , Kwok J.B.J. , Fisher C. , Yeung L.U. , Van Broeckhoven C.
Neurosci. Lett.199:183-186(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-717
131.

"A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)."
Eckman C.B. , Mehta N.D. , Crook R. , Perez-Tur J. , Prihar G. , Pfeiffer E. , Graff-Radford N. , Hinder P. , Yager D. , Zenk B. , Refolo L.M. , Prada C.M. , Younkin S.G. , Hutton M. , Hardy J.
Hum. Mol. Genet.6:2087-2089(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 VAL-716
132.

"Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation."
Cras P. , van Harskamp F. , Hendriks L. , Ceuterick C. , van Duijn C.M. , Stefanko S.Z. , Hofman A. , Kros J.M. , Van Broeckhoven C. , Martin J.J.
Acta Neuropathol.96:253-260(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 GLY-692;CHARACTERIZATION OF PHENOTYPE
133.

"Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease."
Ancolio K. , Dumanchin C. , Barelli H. , Warter J.-M. , Brice A. , Campion D. , Frebourg T. , Checler F.
Proc. Natl. Acad. Sci. U.S.A.96:4119-4124(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 MET-715;CHARACTERIZATION OF VARIANT AD1 MET-715
134.

"High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes."
Finckh U. , Mueller-Thomsen T. , Mann U. , Eggers C. , Marksteiner J. , Meins W. , Binetti G. , Alberici A. , Hock C. , Nitsch R.M. , Gal A.
Am. J. Hum. Genet.66:110-117(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-717
135.

"Novel Leu723Pro amyloid precursor protein mutation increases amyloid beta42(43) peptide levels and induces apoptosis."
Kwok J.B.J. , Li Q.X. , Hallupp M. , Whyte S. , Ames D. , Beyreuther K. , Masters C.L. , Schofield P.R.
Ann. Neurol.47:249-253(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 PRO-723
136.

"Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene."
Murrell J.R. , Hake A.M. , Quaid K.A. , Farlow M.R. , Ghetti B.
Arch. Neurol.57:885-887(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 LEU-717
137.

"Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease."
Kumar-Singh S. , De Jonghe C. , Cruts M. , Kleinert R. , Wang R. , Mercken M. , De Strooper B. , Vanderstichele H. , Loefgren A. , Vanderhoeven I. , Backhovens H. , Vanmechelen E. , Kroisel P.M. , Van Broeckhoven C.
Hum. Mol. Genet.9:2589-2598(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-714;CHARACTERIZATION OF VARIANT AD1 ILE-714;MUTAGENESIS OF VAL-717
138.

"Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy."
Grabowski T.J. , Cho H.S. , Vonsattel J.P.G. , Rebeck G.W. , Greenberg S.M.
Ann. Neurol.49:697-705(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAA-APP ASN-694
139.

"In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease."
Walsh D.M. , Hartley D.M. , Condron M.M. , Selkoe D.J. , Teplow D.B.
Biochem. J.355:869-877(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT AD1 GLY-692
140.

"The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation."
Nilsberth C. , Westlind-Danielsson A. , Eckman C.B. , Condron M.M. , Axelman K. , Forsell C. , Stenh C. , Luthman J. , Teplow D.B. , Younkin S.G. , Naeslund J. , Lannfelt L.
Nat. Neurosci.4:887-893(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 GLY-693
141.

"An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala)."
Pasalar P. , Najmabadi H. , Noorian A.R. , Moghimi B. , Jannati A. , Soltanzadeh A. , Krefft T. , Crook R. , Hardy J.
Neurology58:1574-1575(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ALA-714
142.

"Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation."
Greenberg S.M. , Shin Y. , Grabowski T.J. , Cooper G.E. , Rebeck G.W. , Iglesias S. , Chapon F. , Tournier-Lasserve E. , Baron J.-C.
Neurology60:1020-1022(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAA-APP ASN-694
143.

"A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene."
Rossi G. , Giaccone G. , Maletta R. , Morbin M. , Capobianco R. , Mangieri M. , Giovagnoli A.R. , Bizzi A. , Tomaino C. , Perri M. , Di Natale M. , Tagliavini F. , Bugiani O. , Bruni A.C.
Neurology63:910-912(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 THR-713
144.

"A novel AbetaPP mutation exclusively associated with cerebral amyloid angiopathy."
Obici L. , Demarchi A. , de Rosa G. , Bellotti V. , Marciano S. , Donadei S. , Arbustini E. , Palladini G. , Diegoli M. , Genovese E. , Ferrari G. , Coverlizza S. , Merlini G.
Ann. Neurol.58:639-644(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CAA-APP VAL-705
145.

"An African American family with early-onset Alzheimer disease and an APP (T714I) mutation."
Edwards-Lee T. , Ringman J.M. , Chung J. , Werner J. , Morgan A. , St George-Hyslop P.H. , Thompson P. , Dutton R. , Mlikotic A. , Rogaeva E. , Hardy J.
Neurology64:377-379(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AD1 ILE-714

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