App ELISA Kit for Mouse(Mus musculus) | EIAab.comApp ELISA Kit for Mouse(Mus musculus)

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App (Gene name),

Amyloid beta A4 protein (Protein name ), A4_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

App;

Protein name:

Amyloid beta A4 protein;

Alternative:

Alzheimer disease amyloid A4 protein homolog;ABPP(APP);Amyloidogenic glycoprotein(AG);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, NUMB and DAB1. Binding to DAB1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1 (By similarity). In vitro, it binds MAPT via the MT-binding domains (By similarity). Associates with microtubules in the presence of ATP and in a kinesin-dependent manner (By similarity). Interacts, through a C-terminal domain, with GNAO1 (By similarity). Amyloid beta-42 binds CHRNA7 in hippocampal neurons (By similarity). Beta-amyloid associates with HADH2 (By similarity). Interacts with ANKS1B, TNFRSF21 and AGER (By similarity). Interacts with CPEB1. Interacts with ITM2B. Interacts with ITM2C. Interacts with IDE. Can form homodimers; this is promoted by heparin binding.

Function:

N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

Subcellular Location:

Membrane Single-pass type I membrane protein Membrane clathrin-coated pit Cell surface protein that rapidly becomes internalized via clathrin-coated pits. During maturation, the immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex where complete maturation occurs (O-glycosylated and sulfated). After alpha-secretase cleavage, soluble APP is released into the extracellular space and the C-terminal is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles leaving the late Golgi compartment and returns to the cell surface. Gamma-CTF(59) peptide is located to both the cytoplasm and nuclei of neurons. It can be translocated to the nucleus through association with APBB1 (Fe65). Beta-APP42 associates with FPRL1 at the cell surface and the complex is then rapidly internalized (By similarity). APP sorts to the basolateral surface in epithelial cells (By similarity). During neuronal differentiation, the Thr-743 phosphorylated form is located mainly in growth cones, moderately in neurites and sparingly in the cell body. Casein kinase phosphorylation can occur either at the cell surface or within a post-Golgi compartment.

Protein Attributes:

Sequence length:

770

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

770:

KMQQNGYENP | TYKFFEQMQN |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P12023

Pfam:

PF10515

KEGG:

mmu:11820

UniGene:

Mm.277585

SMR:

P12023

Uniprot:

P12023

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ELISA Kit for Mouse Amyloid beta A4 protein

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E0946h

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96T

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ELISA Kit for Mouse Amyloid beta A4 protein

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E0946m

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96T

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ELISA Kit for Mouse Amyloid beta A4 protein

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E0946r

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ELISA Kit for Mouse Amyloid beta A4 protein

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ELISA Kit for Mouse Amyloid beta A4 protein

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ELISA Kit for Mouse Amyloid beta A4 protein

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ELISA Kit for Mouse Amyloid beta A4 protein

Cat.:

E0946p

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Packing:

96T

CLIA Kit for Mouse Amyloid beta A4 protein

Cat.:

U0946m

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96T

CLIA Kit for Mouse Amyloid beta A4 protein

Cat.:

U0946p

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Packing:

96T

CLIA Kit for Mouse Amyloid beta A4 protein

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CLIA Kit for Mouse Amyloid beta A4 protein

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CLIA Kit for Mouse Amyloid beta A4 protein

MSDS:

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CLIA Kit for Mouse Amyloid beta A4 protein

Cat.:

U0946r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Mouse Amyloid beta A4 protein

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U0946h

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96T

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Polyclonal Antibody for Mouse Amyloid beta A4 protein

Cat.:

P0946Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Amyloid beta A4 protein

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P0946Rb-r

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Polyclonal Antibody for Mouse Amyloid beta A4 protein

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P0946Rb-m

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Polyclonal Antibody for Mouse Amyloid beta A4 protein

Monoclonal Antibody for Mouse Amyloid beta A4 protein

Protein for Mouse Amyloid beta A4 protein

Cat.:

R0946h

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Packing:

1mg

Purity:

>90%

Protein for Mouse Amyloid beta A4 protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"AMELIORATIVE EFFECT OF NOVEL VITAMIN FORMULA WITH HERBAL EXTRACTS ON SCOPOLAMINE-INDUCED ALZHEIMER’S DISEASE"

JEONG MIN LEE, SANDESH SANCHETI, JAE WON PARK, ILL CHAN NOH, WOON DONG CHO, JUNG HO CHOI

From:Asian Journal of Pharmaceutical and Clinical Research

References

1.

"Complementary DNA for the mouse homolog of the human amyloid beta protein precursor."
Yamada T. , Sasaki H. , Furuya H. , Miyata T. , Goto I. , Sakaki Y.
Biochem. Biophys. Res. Commun.149:665-671(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695)
tissue: Brain.
2.

Yamada T.
Submitted (1988-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported."
de Strooper B. , van Leuven F. , van den Berghe H.
Biochim. Biophys. Acta1129:141-143(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695)
strain: BALB/c.
tissue: Brain.
4.

"Molecular cloning, expression, and regulation of hippocampal amyloid precursor protein of senescence accelerated mouse (SAMP8)."
Kumar V.B. , Vyas K. , Franko M. , Choudhary V. , Buddhiraju C. , Alvarez J. , Morley J.E.
Biochem. Cell Biol.79:57-67(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM APP695)
strain: SAMP8.
tissue: Hippocampus.
5.

"Positive and negative regulatory elements for the expression of the Alzheimer's disease amyloid precursor-encoding gene in mouse."
Izumi R. , Yamada T. , Yoshikai S. , Sasaki H. , Hattori M. , Sakai Y.
Gene112:189-195(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM APP770)
tissue: Mammary tumor.
7.

"Structure and expression of the alternatively-spliced forms of mRNA for the mouse homolog of Alzheimer's disease amyloid beta protein precursor."
Yamada T. , Sasaki H. , Dohura K. , Goto I. , Sakaki Y.
Biochem. Biophys. Res. Commun.158:906-912(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-380;ALTERNATIVE SPLICING
tissue: Brain.
tissue: Kidney.
8.

"Sequence of the protease inhibitor domain of the A4 amyloid protein precursor of Mus domesticus."
Fukuchi K. , Martin G.M. , Deeb S.S.
Nucleic Acids Res.17:5396-5396(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-364
strain: CD-1.
tissue: Placenta.
9.

"Introduction of six mutations into the mouse genome using 'Hit and Run' gene-targeting: introduction of familial Alzheimer's disease mutations into the mouse amyloid precursor protein gene and humanization of the A-beta fragment."
Wragg M.A. , Busfield F. , Duff K. , Korenblat K. , Capecchi M. , Loring J.F. , Goate A.M.
Submitted (1996-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 656-737
strain: 129/Sv.
10.

"Regional distribution of the alternatively spliced isoforms of beta APP RNA transcript in the brain of normal, heterozygous and homozygous weaver mutant mice as revealed by in situ hybridization histochemistry."
Sola C. , Mengod G. , Ghetti B. , Palacios J.M. , Triarhou L.C.
Brain Res. Mol. Brain Res.17:340-346(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY OF ALTERNATIVE SPLICED FORMS
11.

"Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I."
Kamal A. , Stokin G.B. , Yang Z. , Xia C.-H. , Goldstein L.S.
Neuron28:449-459(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KNS2
12.

"The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene."
Zambrano N. , Bruni P. , Minopoli G. , Mosca R. , Molino D. , Russo C. , Schettini G. , Sudol M. , Russo T.
J. Biol. Chem.276:19787-19792(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-757
13.

"C-jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK."
Matsuda S. , Yasukawa T. , Homma Y. , Ito Y. , Niikura T. , Hiraki T. , Hirai S. , Ohno S. , Kita Y. , Kawasumi M. , Kouyama K. , Yamamoto T. , Kyriakis J.M. , Nishimoto I.
J. Neurosci.21:6597-6607(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: C-TERMINAL PROTEIN-PROTEIN INTERACTION;MUTAGENESIS OF TYR-728; THR-743; TYR-757; ASN-759 AND TYR-762
14.

"Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2."
Morris S.M. , Cooper J.A.
Traffic2:111-123(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DAB2;MUTAGENESIS OF GLY-756; TYR-757; ASN-759; PRO-760 AND TYR-762
15.

"Interaction of Alzheimer's beta-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade."
Taru H. , Iijima K. , Hase M. , Kirino Y. , Yagi Y. , Suzuki T.
J. Biol. Chem.277:20070-20078(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAPK8IP1;PHOSPHORYLATION
16.

"The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling."
Roncarati R. , Sestan N. , Scheinfeld M.H. , Berechid B.E. , Lopez P.A. , Meucci O. , McGlade J.C. , Rakic P. , D'Adamio L.
Proc. Natl. Acad. Sci. U.S.A.99:7102-7107(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION OF CTF PEPTIDES WITH NUMB
17.

"The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurons in culture."
Cupers P. , Orlans I. , Craessaerts K. , Annaert W. , De Strooper B.
J. Neurochem.78:1168-1178(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING BY GAMMA SECRETASE;INTERACTION WITH APBB1
18.

"The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-nitric oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo."
Cappai R. , Cheng F. , Ciccotosto G.D. , Needham B.E. , Masters C.L. , Multhaup G. , Fransson L.A. , Mani K.
J. Biol. Chem.280:13913-13920(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;FUNCTION
19.

"Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation."
Cao Q. , Huang Y.-S. , Kan M.-C. , Richter J.D.
Mol. Cell. Biol.25:10930-10939(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CPEB1
20.

"Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein."
Andersen O.M. , Reiche J. , Schmidt V. , Gotthardt M. , Spoelgen R. , Behlke J. , von Arnim C.A. , Breiderhoff T. , Jansen P. , Wu X. , Bales K.R. , Cappai R. , Masters C.L. , Gliemann J. , Mufson E.J. , Hyman B.T. , Paul S.M. , Nykjaer A. , more...
Proc. Natl. Acad. Sci. U.S.A.102:13461-13466(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH APP

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