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Index > Protein center > Adam10(Gene name) > Mouse
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  • Adam10 (Gene name),
  • Disintegrin and metalloproteinase domain-containing protein 10 (Protein name ),  ADA10_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Adam10(Kuz;Madm);
    Protein name:
    Disintegrin and metalloproteinase domain-containing protein 10(ADAM 10);
    Alternative:
    Mammalian disintegrin-metalloprotease;Kuzbanian protein homolog;
    CD:
    CD156c;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Forms a ternary EFNA5-EPHA3-ADAM10 complex mediating EFNA5 extracellular domain shedding by ADAM10 which regulates the EFNA5-EPHA3 complex internalization and function (By similarity). Interacts with EPHA2.
    Function:
    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|-Leu-688'. Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. May regulate the EFNA5-EPHA3 signaling.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    749
    Sequence:
    50:
    MVLPTVLILL | LSWAAGLGGQ | YGNPLNKYIR | HYEGLSYNVD | SLHQKHQRAK | 
    100:
    RAVSHEDQFL | LLDFHAHGRQ | FNLRMKRDTS | LFSDEFKVET | SNKVLDYDTS | 
    150:
    HIYTGHIYGE | EGSFSHGSVI | DGRFEGFIKT | RGGTFYIEPA | ERYIKDRILP | 
    200:
    FHSVIYHEDD | INYPHKYGPQ | GGCADHSVFE | RMRKYQMTGV | EEGARAHPEK | 
    250:
    HAASSGPELL | RKKRTTLAER | NTCQLYIQTD | HLFFKYYGTR | EAVIAQISSH | 
    300:
    VKAIDTIYQT | TDFSGIRNIS | FMVKRIRINT | TSDEKDPTNP | FRFPNIGVEK | 
    350:
    FLELNSEQNH | DDYCLAYVFT | DRDFDDGVLG | LAWVGAPSGS | SGGICEKSKL | 
    400:
    YSDGKKKSLN | TGIITVQNYG | SHVPPKVSHI | TFAHEVGHNF | GSPHDSGTEC | 
    450:
    TPGESKNLGQ | KENGNYIMYA | RATSGDKLNN | NKFSLCSIRN | ISQVLEKKRN | 
    500:
    NCFVESGQPI | CGNGMVEQGE | ECDCGYSDQC | KDDCCFDANQ | PEGKKCKLKP | 
    550:
    GKQCSPSQGP | CCTAQCAFKS | KSEKCRDDSD | CAKEGICNGF | TALCPASDPK | 
    600:
    PNFTDCNRHT | QVCINGQCAG | SICEKYDLEE | CTCASSDGKD | DKELCHVCCM | 
    650:
    KKMAPSTCAS | TGSLQWSKQF | SGRTITLQPG | SPCNDFRGYC | DVFMRCRLVD | 
    700:
    ADGPLARLKK | AIFSPQLYEN | IAEWIVAHWW | AVLLMGIALI | MLMAGFIKIC | 
    749:
    SVHTPSSNPK | LPPPKPLPGT | LKRRRPPQPI | QQPPRQRPRE | SYQMGHMRR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ADAM 10
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    E0766h
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    ELISA Kit for Mouse ADAM 10
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    ELISA Kit for Mouse ADAM 10
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    E0766m
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    ELISA Kit for Mouse ADAM 10
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    E0766b
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    ELISA Kit for Mouse ADAM 10
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    E0766r
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    96T
    CLIA Kit for Mouse ADAM 10
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    U0766m
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    Packing:
    96T
    CLIA Kit for Mouse ADAM 10
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse ADAM 10
    Cat.:
    U0766h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse ADAM 10
    Cat.:
    U0766b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse ADAM 10
    Cat.:
    U0766r
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    Packing:
    96T
    Polyclonal Antibody for Mouse ADAM 10
    Cat.:
    P0766Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ADAM 10
    Cat.:
    P0766Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ADAM 10
    Polyclonal Antibody for Mouse ADAM 10
    Polyclonal Antibody for Mouse ADAM 10
    Cat.:
    P0766Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse ADAM 10
    Monoclonal Antibody for Mouse ADAM 10
    Monoclonal Antibody for Mouse ADAM 10
    Monoclonal Antibody for Mouse ADAM 10
    Monoclonal Antibody for Mouse ADAM 10
    Protein for Mouse ADAM 10
    Protein for Mouse ADAM 10
    Protein for Mouse ADAM 10
    Protein for Mouse ADAM 10
    Protein for Mouse ADAM 10

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    References
    1. 1.
      "Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis."
      Pan D. , Rubin G.M.
      Cell90:271-280(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 252-749
      strain: C57BL/6J.
      tissue: Bone.
      tissue: Vagina.
    5. 5.
      "Regulated cleavage of a contact-mediated axon repellent."
      Hattori M. , Osterfield M. , Flanagan J.G.
      Science289:1360-1365(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EPHA2
    6. 6.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-279
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