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Index > Protein center > ADAM15(Gene name) > Human
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  • ADAM15 (Gene name),
  • Disintegrin and metalloproteinase domain-containing protein 15 (Protein name ),  ADA15_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ADAM15(MDC15);
    Protein name:
    Disintegrin and metalloproteinase domain-containing protein 15(ADAM 15);
    Alternative:
    Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15(MDC-15);Metalloprotease RGD disintegrin protein;Metargidin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ITAGV-ITGB3 (vitronectin receptor), PACSIN3 and SNX9. PACSIN3 and SNX9 preferentially bind the precursor but not the processed form of ADAM15, suggesting that the interaction occurs in a secretory pathway compartment prior to the medial Golgi (By similarity). Interacts with ITAG9-ITGB1 (By similarity). Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, and SRC.
    Function:
    Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain.
    Subcellular Location:
    Endomembrane system Single-pass type I membrane protein Cell junction adherens junction Cell projection cilium flagellum Cytoplasmic vesicle secretory vesicle acrosome The majority of the protein is localized in a perinuclear compartment which may correspond to the trans-Golgi network or the late endosome. The pro-protein is the major detectable form on the cell surface, whereas the majority of the protein in the cell is processed.
    Protein Attributes:
    Sequence length:
    863
    Sequence:
    50:
    MRLALLWALG | LLGAGSPLPS | WPLPNIGGTE | EQQAESEKAP | REPLEPQVLQ | 
    100:
    DDLPISLKKV | LQTSLPEPLR | IKLELDGDSH | ILELLQNREL | VPGRPTLVWY | 
    150:
    QPDGTRVVSE | GHTLENCCYQ | GRVRGYAGSW | VSICTCSGLR | GLVVLTPERS | 
    200:
    YTLEQGPGDL | QGPPIISRIQ | DLHLPGHTCA | LSWRESVHTQ | KPPEHPLGQR | 
    250:
    HIRRRRDVVT | ETKTVELVIV | ADHSEAQKYR | DFQHLLNRTL | EVALLLDTFF | 
    300:
    RPLNVRVALV | GLEAWTQRDL | VEISPNPAVT | LENFLHWRRA | HLLPRLPHDS | 
    350:
    AQLVTGTSFS | GPTVGMAIQN | SICSPDFSGG | VNMDHSTSIL | GVASSIAHEL | 
    400:
    GHSLGLDHDL | PGNSCPCPGP | APAKTCIMEA | STDFLPGLNF | SNCSRRALEK | 
    450:
    ALLDGMGSCL | FERLPSLPPM | AAFCGNMFVE | PGEQCDCGFL | DDCVDPCCDS | 
    500:
    LTCQLRPGAQ | CASDGPCCQN | CQLRPSGWQC | RPTRGDCDLP | EFCPGDSSQC | 
    550:
    PPDVSLGDGE | PCAGGQAVCM | HGRCASYAQQ | CQSLWGPGAQ | PAAPLCLQTA | 
    600:
    NTRGNAFGSC | GRNPSGSYVS | CTPRDAICGQ | LQCQTGRTQP | LLGSIRDLLW | 
    650:
    ETIDVNGTEL | NCSWVHLDLG | SDVAQPLLTL | PGTACGPGLV | CIDHRCQRVD | 
    700:
    LLGAQECRSK | CHGHGVCDSN | RHCYCEEGWA | PPDCTTQLKA | TSSLTTGLLL | 
    750:
    SLLVLLVLVM | LGASYWYRAR | LHQRLCQLKG | PTCQYRAAQS | GPSERPGPPQ | 
    800:
    RALLARGTKQ | ASALSFPAPP | SRPLPPDPVS | KRLQAELADR | PNPPTRPLPA | 
    850:
    DPVVRSPKSQ | GPAKPPPPRK | PLPADPQGRC | PSGDLPGPGA | GIPPLVVPSR | 
    863:
    PAPPPPTVSS | LYL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    Pfam:
    UniGene:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADAM 15
    ELISA Kit for Human ADAM 15
    ELISA Kit for Human ADAM 15
    CLIA Kit for Human ADAM 15
    CLIA Kit for Human ADAM 15
    CLIA Kit for Human ADAM 15
    Polyclonal Antibody for Human ADAM 15
    Polyclonal Antibody for Human ADAM 15
    Polyclonal Antibody for Human ADAM 15
    Monoclonal Antibody for Human ADAM 15
    Monoclonal Antibody for Human ADAM 15
    Monoclonal Antibody for Human ADAM 15
    Protein for Human ADAM 15
    Protein for Human ADAM 15
    Protein for Human ADAM 15

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The ectodomain shedding of E-cadherin by ADAM15 supports ErbB receptor activation."
      Najy A.J. , Day K.C. , Day M.L.
      J. Biol. Chem.283:18393-18401(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    2. 2.
      "Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence."
      Kraetzschmar J. , Lum L. , Blobel C.P.
      J. Biol. Chem.271:4593-4596(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT THR-191
      tissue: Mammary carcinoma.
    3. 3.
      "Expression of a disintegrin-like protein in cultured human vascular cells and in vivo."
      Herren B. , Raines E.W. , Ross R.
      FASEB J.11:173-180(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT THR-191
      tissue: Umbilical vein.
    4. 4.
      "ADAM-15 inhibits wound healing in human intestinal epithelial cell monolayers."
      Charrier L. , Yan Y. , Driss A. , Laboisse C.L. , Sitaraman S.V. , Merlin D.
      Am. J. Physiol.288:G346-G353(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10);FUNCTION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING (ISOFORM 2)
    5. 5.
      "ADAM15 gene structure and differential alternative exon use in human tissues."
      Kleino I. , Ortiz R.M. , Huovila A.P.
      BMC Mol. Biol.8:90-90(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10);VARIANT THR-191
    6. 6.
      "Distinct functions of natural ADAM-15 cytoplasmic domain variants in human mammary carcinoma."
      Zhong J.L. , Poghosyan Z. , Pennington C.J. , Scott X. , Handsley M.M. , Warn A. , Gavrilovic J. , Honert K. , Kruger A. , Span P.N. , Sweep F.C. , Edwards D.R.
      Mol. Cancer Res.6:383-394(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 4 AND 10);ALTERNATIVE SPLICING;INTERACTION WITH GRB2; MAPK1; MAPK3; NCK1; PTK6; SH3PXD2A AND SRC
    7. 7.
      "Characterization of human ADAM15 gene and promoter, and evidence for alternative exon use."
      Karkkainen I. , Ortiz R.M. , Huovila A.-P.J.
      Submitted (2004-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8 AND 9);VARIANT THR-191
    8. 8.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-191
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 12 AND 13);VARIANTS THR-191 AND LYS-216
      tissue: Tongue.
    10. 10.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 11)
      tissue: Embryo.
    11. 11.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT THR-191
      tissue: Kidney.
    13. 13.
      "Expression of members of a novel membrane linked metalloproteinase family (ADAM) in human articular chondrocytes."
      McKie N. , Edwards T. , Dallas D.J. , Houghton A. , Stringer B. , Graham R. , Russell G. , Croucher P.I.
      Biochem. Biophys. Res. Commun.230:335-339(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    14. 14.
      "Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3."
      Zhang X.P. , Kamata T. , Yokoyama K. , Puzon-McLaughlin W. , Takada Y.
      J. Biol. Chem.273:7345-7350(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHAV-BETA3
    15. 15.
      "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
      Howard L. , Nelson K.K. , Maciewicz R.A. , Blobel C.P.
      J. Biol. Chem.274:31693-31699(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3GL2 AND SNX9
    16. 16.
      "Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells."
      Nath D. , Slocombe P.M. , Stephens P.E. , Warn A. , Hutchinson G.R. , Yamada K.M. , Docherty A.J. , Murphy G.
      J. Cell Sci.112:579-587(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHAV-BETA3 AND INTEGRIN ALPHA5-BETA1
    17. 17.
      "ADAM15 is an adherens junction molecule whose surface expression can be driven by VE-cadherin."
      Ham C. , Levkau B. , Raines E.W. , Herren B.
      Exp. Cell Res.279:239-247(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    18. 18.
      "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases."
      Poghosyan Z. , Robbins S.M. , Houslay M.D. , Webster A. , Murphy G. , Edwards D.R.
      J. Biol. Chem.277:4999-5007(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-715 AND TYR-735;INTERACTION WITH GRB2; LCK AND HCK
    19. 19.
      "The role of ADAM 15 in glomerular mesangial cell migration."
      Martin J. , Eynstone L.V. , Davies M. , Williams J.D. , Steadman R.
      J. Biol. Chem.277:33683-33689(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    20. 20.
      "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."
      Abram C.L. , Seals D.F. , Pass I. , Salinsky D. , Maurer L. , Roth T.M. , Courtneidge S.A.
      J. Biol. Chem.278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3PXD2A
    21. 21.
      "Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling."
      Bohm B.B. , Aigner T. , Roy B. , Brodie T.A. , Blobel C.P. , Burkhardt H.
      Arthritis Rheum.52:1100-1109(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    22. 22.
      "Inhibition of airway smooth muscle adhesion and migration by the disintegrin domain of ADAM-15."
      Lu D. , Xie S. , Sukkar M.B. , Lu X. , Scully M.F. , Chung K.F.
      Am. J. Respir. Cell Mol. Biol.37:494-500(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    23. 23.
      "ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells."
      Charrier L. , Yan Y. , Nguyen H.T. , Dalmasso G. , Laboisse C.L. , Gewirtz A.T. , Sitaraman S.V. , Merlin D.
      J. Biol. Chem.282:16948-16958(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF 484-ARG-GLY-485
    24. 24.
      "ADAM15 suppresses cell motility by driving integrin alpha5beta1 cell surface expression via Erk inactivation."
      Chen Q. , Meng L.H. , Zhu C.H. , Lin L.P. , Lu H. , Ding J.
      Int. J. Biochem. Cell Biol.40:2164-2173(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    25. 25.
      "Characterization of the catalytic activity of the membrane-anchored metalloproteinase ADAM15 in cell-based assays."
      Maretzky T. , Yang G. , Ouerfelli O. , Overall C.M. , Worpenberg S. , Hassiepen U. , Eder J. , Blobel C.P.
      Biochem. J.420:105-113(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    26. 26.
      "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."
      Kleino I. , Ortiz R.M. , Yritys M. , Huovila A.P. , Saksela K.
      J. Cell. Biochem.108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCK; ITSN1; ITSN2; LYN; NCF1; NEPHROCYSTIN; SH3PXD2A; SNX33; SNX9 AND SRC
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