Gene name:
Angpt2 (Agpt2) ;
Protein name:
Angiopoietin-2 (ANG-2) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Can induce tyrosine phosphorylation of TIE2. Binds to Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Subcellular Location:
Secreted
Protein Attributes:
50:
MWQIIFLTFG | WDLVLASAYS | NFRKSVDSTG | RRQYQVQNGP | CSYTFLLPET |
100:
DSCRSSSSPY | MSNAVQRDAP | LDYDDSVQRL | QVLENILENN | TQWLMKLENY |
150:
IQDNMKKEMV | EIQQNVVQNQ | TAVMIEIGTS | LLNQTAAQTR | KLTDVEAQVL |
200:
NQTTRLELQL | LQHSISTNKL | EKQILDQTSE | INKLQNKNSF | LEQKVLDMEG |
250:
KHSEQLQSMK | EQKDELQVLV | SKQSSVIDEL | EKKLVTATVN | NSLLQKQQHD |
300:
LMETVNSLLT | MMSSPNSKSS | VAIRKEEQTT | FRDCAEIFKS | GLTTSGIYTL |
350:
TFPNSTEEIK | AYCDMDVGGG | GWTVIQHRED | GSVDFQRTWK | EYKEGFGSPL |
400:
GEYWLGNEFV | SQLTGQHRYV | LKIQLKDWEG | NEAHSLYDHF | YLAGEESNYR |
450:
IHLTGLTGTA | GKISSISQPG | SDFSTKDSDN | DKCICKCSQM | LSGGWWFDAC |
496:
GPSNLNGQYY | PQKQNTNKFN | GIKWYYWKGS | GYSLKATTMM | IRPADF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Dog
ELISA Kit for Mouse ANG-2
ELISA Kit for Mouse ANG-2
ELISA Kit for Mouse ANG-2
ELISA Kit for Mouse ANG-2
ELISA Kit for Mouse ANG-2
ELISA Kit for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Polyclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
Monoclonal Antibody for Mouse ANG-2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
Maisonpierre P.C.
,
Suri C.
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Science277:55-60(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Uterus .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Head .
tissue :
Ovary .
tissue :
Spleen .
tissue :
Uterus .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]