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Index > Protein center > ADAMTS4(Gene name) > Human
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  • ADAMTS4 (Gene name),
  • A disintegrin and metalloproteinase with thrombospondin motifs 4 (Protein name ),  ATS4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    ADAMTS4(UNQ769/PRO1563;KIAA0688);
    Protein name:
    A disintegrin and metalloproteinase with thrombospondin motifs 4(ADAM-TS 4;ADAM-TS4;ADAMTS-4);
    Alternative:
    ADMP-1;Aggrecanase-1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SRPX2.
    Function:
    Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    837
    Sequence:
    50:
    MSQTGSHPGR | GLAGRWLWGA | QPCLLLPIVP | LSWLVWLLLL | LLASLLPSAR | 
    100:
    LASPLPREEE | IVFPEKLNGS | VLPGSGAPAR | LLCRLQAFGE | TLLLELEQDS | 
    150:
    GVQVEGLTVQ | YLGQAPELLG | GAEPGTYLTG | TINGDPESVA | SLHWDGGALL | 
    200:
    GVLQYRGAEL | HLQPLEGGTP | NSAGGPGAHI | LRRKSPASGQ | GPMCNVKAPL | 
    250:
    GSPSPRPRRA | KRFASLSRFV | ETLVVADDKM | AAFHGAGLKR | YLLTVMAAAA | 
    300:
    KAFKHPSIRN | PVSLVVTRLV | ILGSGEEGPQ | VGPSAAQTLR | SFCAWQRGLN | 
    350:
    TPEDSDPDHF | DTAILFTRQD | LCGVSTCDTL | GMADVGTVCD | PARSCAIVED | 
    400:
    DGLQSAFTAA | HELGHVFNML | HDNSKPCISL | NGPLSTSRHV | MAPVMAHVDP | 
    450:
    EEPWSPCSAR | FITDFLDNGY | GHCLLDKPEA | PLHLPVTFPG | KDYDADRQCQ | 
    500:
    LTFGPDSRHC | PQLPPPCAAL | WCSGHLNGHA | MCQTKHSPWA | DGTPCGPAQA | 
    550:
    CMGGRCLHMD | QLQDFNIPQA | GGWGPWGPWG | DCSRTCGGGV | QFSSRDCTRP | 
    600:
    VPRNGGKYCE | GRRTRFRSCN | TEDCPTGSAL | TFREEQCAAY | NHRTDLFKSF | 
    650:
    PGPMDWVPRY | TGVAPQDQCK | LTCQAQALGY | YYVLEPRVVD | GTPCSPDSSS | 
    700:
    VCVQGRCIHA | GCDRIIGSKK | KFDKCMVCGG | DGSGCSKQSG | SFRKFRYGYN | 
    750:
    NVVTIPAGAT | HILVRQQGNP | GHRSIYLALK | LPDGSYALNG | EYTLMPSPTD | 
    800:
    VVLPGAVSLR | YSGATAASET | LSGHGPLAQP | LTLQVLVAGN | PQDTRLRYSF | 
    837:
    FVPRPTPSTP | RPTPQDWLHR | RAQILEILRR | RPWAGRK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADAM-TS 4
    Cat.:
    E1804h
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human ADAM-TS 4
    Cat.:
    E1804r
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    Please sign in first.
    ELISA Kit for Human ADAM-TS 4
    Cat.:
    E1804b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human ADAM-TS 4
    Cat.:
    E1804m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADAM-TS 4
    Cat.:
    U1804r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADAM-TS 4
    Cat.:
    U1804b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADAM-TS 4
    Cat.:
    U1804h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADAM-TS 4
    Cat.:
    U1804m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ADAM-TS 4
    Cat.:
    P1804Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADAM-TS 4
    Polyclonal Antibody for Human ADAM-TS 4
    Cat.:
    P1804Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ADAM-TS 4
    Cat.:
    P1804Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ADAM-TS 4
    Monoclonal Antibody for Human ADAM-TS 4
    Monoclonal Antibody for Human ADAM-TS 4
    Monoclonal Antibody for Human ADAM-TS 4
    Protein for Human ADAM-TS 4
    Protein for Human ADAM-TS 4
    Protein for Human ADAM-TS 4
    Protein for Human ADAM-TS 4

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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ARG-626
    2. 2.
      "An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients."
      Wainwright S.D. , Bondeson J. , Hughes C.E.
      Matrix Biol.25:317-320(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 651-777 (ISOFORM 2)
      tissue: Synovium.
    3. 3.
      "ADAMTS-4 genomic locus."
      Sawaji Y. , Nagase H. , Saklatvala J. , Clark A.R.
      Submitted (2001-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Ishikawa K. , Nagase T. , Suyama M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-77 AND ARG-626
      tissue: Brain.
    5. 5.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-626
    6. 6.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-4; ASN-304; VAL-369; THR-552 AND ALA-564
      tissue: Brain.
    8. 8.
      "The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage."
      Tortorella M.D. , Pratta M.A. , Liu R.-Q. , Abbaszade I. , Ross H. , Burn T.C. , Arner E.C.
      J. Biol. Chem.275:25791-25797(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION
    9. 9.
      "Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR."
      Royer-Zemmour B. , Ponsole-Lenfant M. , Gara H. , Roll P. , Leveque C. , Massacrier A. , Ferracci G. , Cillario J. , Robaglia-Schlupp A. , Vincentelli R. , Cau P. , Szepetowski P.
      Hum. Mol. Genet.17:3617-3630(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SRPX2
    10. 10.
      "ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain."
      Wainwright S.D. , Bondeson J. , Caterson B. , Hughes C.E.
      Arthritis Rheum.65:2866-2875(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING;TISSUE SPECIFICITY (ISOFORM 2)
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 213-520 ALONE AND IN COMPLEX WITH INHIBITOR;ACTIVE SITE;COFACTOR;ZINC-BINDING SITES;DISULFIDE BONDS
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