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Index > Protein center > Bax(Gene name) > Rat
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  • Bax (Gene name),
  • Apoptosis regulator BAX (Protein name ),  BAX_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (4)
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  • Gene name:
    Bax;
    Protein name:
    Apoptosis regulator BAX;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Homodimer. Forms higher oligomers under stress conditions. Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells.
    Function:
    Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
    Subcellular Location:
    Isoform Gamma Cytoplasm
    Protein Attributes:
    Sequence length:
    192
    Sequence:
    50:
    MDGSGEQLGG | GGPTSSEQIM | KTGAFLLQGF | IQDRAGRMAG | ETPELTLEQP | 
    100:
    PQDASTKKLS | ECLRRIGDEL | DSNMELQRMI | ADVDTDSPRE | VFFRVAADMF | 
    150:
    ADGNFNWGRV | VALFYFASKL | VLKALCTKVP | ELIRTIMGWT | LDFLRERLLV | 
    192:
    WIQDQGGWDG | LLSYFGTPTW | QTVTIFVAGV | LTASLTIWKK | MG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    KEGG:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Apoptosis regulator BAX
    Cat.:
    E1343h
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    96T
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    ELISA Kit for Rat Apoptosis regulator BAX
    Cat.:
    E1343m
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    96T
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    ELISA Kit for Rat Apoptosis regulator BAX
    Cat.:
    E1343r
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    96T
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    ELISA Kit for Rat Apoptosis regulator BAX
    Cat.:
    E1343b
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    Packing:
    96T
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    CLIA Kit for Rat Apoptosis regulator BAX
    Cat.:
    U1343r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Apoptosis regulator BAX
    Cat.:
    U1343m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Apoptosis regulator BAX
    Cat.:
    U1343h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Apoptosis regulator BAX
    Cat.:
    U1343b
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Rat Apoptosis regulator BAX
    Cat.:
    P1343Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Apoptosis regulator BAX
    Cat.:
    P1343Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Apoptosis regulator BAX
    Cat.:
    P1343Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Apoptosis regulator BAX
    Monoclonal Antibody for Rat Apoptosis regulator BAX
    Monoclonal Antibody for Rat Apoptosis regulator BAX
    Monoclonal Antibody for Rat Apoptosis regulator BAX
    Monoclonal Antibody for Rat Apoptosis regulator BAX
    Protein for Rat Apoptosis regulator BAX
    Protein for Rat Apoptosis regulator BAX
    Protein for Rat Apoptosis regulator BAX
    Protein for Rat Apoptosis regulator BAX

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    References
    1. 1.
      "The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein."
      Han J. , Sabbatini P. , Perez D. , Rao L. , Modha D. , White E.
      Genes Dev.10:461-477(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Cloning of the 3' end of rat bax-alpha and corresponding developmental down-regulation in differentiating primary, cultured oligodendrocytes."
      Madison D.L. , Pfeiffer S.E.
      Neurosci. Lett.220:183-186(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 75-192
      tissue: Brain.
    3. 3.
      "Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels."
      Tilly J.L. , Tilly K.I. , Kenton M.L. , Johnson A.L.
      Endocrinology136:232-241(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-169
      strain: Sprague-Dawley.
      tissue: Ovary.
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