BCL2 ELISA Kit for Human(Homo sapiens) | EIAab.comBCL2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > BCL2(Gene name) > Human

BCL2 (Gene name),

Apoptosis regulator Bcl-2 (Protein name ), BCL2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BCL2;

Protein name:

Apoptosis regulator Bcl-2;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms homodimers, and heterodimers with BAX, BAD, BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs, and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1, BBC3, BCL2L1, BNIPL, EI24, MRPL41, RAF-1 and TP53BP2. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets. Interacts with BAG1 in an ATP-dependent manner.

Function:

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

Subcellular Location:

Mitochondrion outer membrane Single-pass membrane protein Nucleus membrane Single-pass membrane protein Endoplasmic reticulum membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

239

Sequence:

50:

100:

150:

200:

239:

LYGPSMRPLF | DFSWLSLKTL | LSLALVGACI | TLGAYLGHK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P10415

MIM:

151430

KEGG:

hsa:596

STRING:

9606.ENSP00000329623

String:

P10415

Pfam:

PF00452

UniGene:

Hs.150749

Uniprot:

P10415

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778r

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778b

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778h

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778m

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778c

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ELISA Kit for Human Apoptosis regulator Bcl-2

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E0778d

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778r

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778b

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778h

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778d

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778m

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96T

CLIA Kit for Human Apoptosis regulator Bcl-2

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U0778c

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96T

Polyclonal Antibody for Human Apoptosis regulator Bcl-2

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P0778Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Apoptosis regulator Bcl-2

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P0778Rb-m

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Polyclonal Antibody for Human Apoptosis regulator Bcl-2

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P0778Rb-r

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Polyclonal Antibody for Human Apoptosis regulator Bcl-2

Monoclonal Antibody for Human Apoptosis regulator Bcl-2

Protein for Human Apoptosis regulator Bcl-2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma."
Tsujimoto Y. , Croce C.M.
Proc. Natl. Acad. Sci. U.S.A.83:5214-5218(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
2.

"Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo."
Eguchi Y. , Ewert D.L. , Tsujimoto Y.
Nucleic Acids Res.20:4187-4192(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 96; 110 AND 237
3.

"Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation."
Cleary M.L. , Smith S.D. , Sklar J.
Cell47:19-28(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
4.

"Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma."
Seto M. , Jaeger U. , Hockett R.D. , Graninger W. , Bennett S. , Goldman P. , Korsmeyer S.J.
EMBO J.7:123-131(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA);VARIANT SER-7
5.

"Consequences of the t(14;18) chromosomal translocation in follicular lymphoma: deregulated expression of a chimeric and mutated BCL-2 gene."
Hua C. , Zorn S. , Jensen J.P. , Coupland R.W. , Ko H.S. , Wright J.J. , Bakhshi A.
Oncogene Res.2:263-275(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT SER-7
6.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT THR-43
7.

"DNA sequence and analysis of human chromosome 18."
Nusbaum C. , Zody M.C. , Borowsky M.L. , Kamal M. , Kodira C.D. , Taylor T.D. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Abouelleil A. , Allen N.R. , Anderson S. , Bloom T. , Bugalter B. , Butler J. , more...
Nature437:551-555(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue: Testis.
10.

"Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas."
Tanaka S. , Louie D.C. , Kant J.A. , Reed J.C.
Blood79:229-237(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-131 (ISOFORM ALPHA);VARIANTS NON-HODGKIN LYMPHOMA SER-59 AND ILE-93
11.

"Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death."
Hockenbery D. , Nunez G. , Milliman C. , Schreiber R.D. , Korsmeyer S.J.
Nature348:334-336(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
12.

"BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax."
Yin X.-M. , Oltvai Z.N. , Korsmeyer S.J.
Nature369:321-323(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS
13.

"BAG-1 modulates the chaperone activity of Hsp70/Hsc70."
Takayama S. , Bimston D.N. , Matsuzawa S.-I. , Freeman B.C. , Aime-Sempe C. , Xie Z. , Morimoto R.I. , Reed J.C.
EMBO J.16:4887-4896(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAG1
14.

"Conversion of Bcl-2 to a Bax-like death effector by caspases."
Cheng E.H.-Y. , Kirsch D.G. , Clem R.J. , Ravi R. , Kastan M.B. , Bedi A. , Ueno K. , Hardwick J.M.
Science278:1966-1968(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY CASPASES;MUTAGENESIS
15.

"The p53-binding protein 53BP2 also interacts with Bcl2 and impedes cell cycle progression at G2/M."
Naumovski L. , Cleary M.L.
Mol. Cell. Biol.16:3884-3892(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TP53BP2
16.

"Phosphorylation of Bcl2 and regulation of apoptosis."
Ruvolo P.P. , Deng X. , May W.S.
Leukemia15:515-522(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON PHOSPHORYLATION
17.

"BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M."
Yamamoto K. , Ichijo H. , Korsmeyer S.J.
Mol. Cell. Biol.19:8469-8478(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ASK1/JNK1
18.

"PUMA induces the rapid apoptosis of colorectal cancer cells."
Yu J. , Zhang L. , Hwang P.M. , Kinzler K.W. , Vogelstein B.
Mol. Cell7:673-682(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BBC3 AND BCL2L1
19.

"BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis."
Qin W. , Hu J. , Guo M. , Xu J. , Li J. , Yao G. , Zhou X. , Jiang H. , Zhang P. , Shen L. , Wan D. , Gu J.
Biochem. Biophys. Res. Commun.308:379-385(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BNIPL
20.

"The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."
Kang C.B. , Tai J. , Chia J. , Yoon H.S.
FEBS Lett.579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FKBP8
21.

"p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association."
Jin S. , Zhuo Y. , Guo W. , Field J.
J. Biol. Chem.280:24698-24705(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAF1
22.

"BMRP is a Bcl-2 binding protein that induces apoptosis."
Chintharlapalli S.R. , Jasti M. , Malladi S. , Parsa K.V.L. , Ballestero R.P. , Gonzalez-Garcia M.
J. Cell. Biochem.94:611-626(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRPL41
23.

"Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."
Portier B.P. , Taglialatela G.
J. Biol. Chem.281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FKBP8
24.

"JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."
Wei Y. , Pattingre S. , Sinha S. , Bassik M. , Levine B.
Mol. Cell30:678-688(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-69; SER-70 AND SER-87 BY MAPK8/JNK1;FUNCTION
25.

"Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2."
Welch C. , Santra M.K. , El-Assaad W. , Zhu X. , Huber W.E. , Keys R.A. , Teodoro J.G. , Green M.R.
Cancer Res.69:6782-6789(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH G0S2
26.

"Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect."
Eliseev R.A. , Malecki J. , Lester T. , Zhang Y. , Humphrey J. , Gunter T.E.
J. Biol. Chem.284:9692-9699(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIF
27.

"Prolyl hydroxylase 3 interacts with Bcl-2 to regulate doxorubicin-induced apoptosis in H9c2 cells."
Liu Y. , Huo Z. , Yan B. , Lin X. , Zhou Z.N. , Liang X. , Zhu W. , Liang D. , Li L. , Liu Y. , Zhao H. , Sun Y. , Chen Y.H.
Biochem. Biophys. Res. Commun.401:231-237(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EGLN3
28.

"Parkin mono-ubiquitinates Bcl-2 and regulates autophagy."
Chen D. , Gao F. , Li B. , Wang H. , Xu Y. , Zhu C. , Wang G.
J. Biol. Chem.285:38214-38223(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION BY PARK2
29.

"Human Bop is a novel BH3-only member of the Bcl-2 protein family."
Zhang X. , Weng C. , Li Y. , Wang X. , Jiang C. , Li X. , Xu Y. , Chen Q. , Pan L. , Tang H.
Protein Cell3:790-801(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BOP/C22ORF29
30.

"Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma."
Chiorazzi M. , Rui L. , Yang Y. , Ceribelli M. , Tishbi N. , Maurer C.W. , Ranuncolo S.M. , Zhao H. , Xu W. , Chan W.C. , Jaffe E.S. , Gascoyne R.D. , Campo E. , Rosenwald A. , Ott G. , Delabie J. , Rimsza L.M. , Shaham S. , more...
Proc. Natl. Acad. Sci. U.S.A.110:3943-3948(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FBXO10;UBIQUITINATION;IDENTIFICATION IN THE SCF(FBXO10) COMPLEX
31.

"Solution structure of the antiapoptotic protein bcl-2."
Petros A.M. , Medek A. , Nettesheim D.G. , Kim D.H. , Yoon H.S. , Swift K. , Matayoshi E.D. , Oltersdorf T. , Fesik S.W.
Proc. Natl. Acad. Sci. U.S.A.98:3012-3017(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-207
32.

"An inhibitor of Bcl-2 family proteins induces regression of solid tumours."
Oltersdorf T. , Elmore S.W. , Shoemaker A.R. , Armstrong R.C. , Augeri D.J. , Belli B.A. , Bruncko M. , Deckwerth T.L. , Dinges J. , Hajduk P.J. , Joseph M.K. , Kitada S. , Korsmeyer S.J. , Kunzer A.R. , Letai A. , Li C. , Mitten M.J. , Nettesheim D.G. , more...
Nature435:677-681(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 45-207
33.

"Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL."
Bruncko M. , Oost T.K. , Belli B.A. , Ding H. , Joseph M.K. , Kunzer A. , Martineau D. , McClellan W.J. , Mitten M. , Ng S.-C. , Nimmer P.M. , Oltersdorf T. , Park C.-M. , Petros A.M. , Shoemaker A.R. , Song X. , Wang X. , Wendt M.D. , more...
J. Med. Chem.50:641-662(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 44-207

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