C4BPA ELISA Kit for Human(Homo sapiens) | EIAab.comC4BPA ELISA Kit for Human(Homo sapiens)

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C4BPA (Gene name),

C4b-binding protein alpha chain (Protein name ), C4BPA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

C4BPA(C4BP);

Protein name:

C4b-binding protein alpha chain(C4bp);

Alternative:

Proline-rich protein(PRP);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.

Function:

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

597

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

597:

TGKRLMQCLP | NPEDVKMALE | VYKLSLEIEQ | LELQRDSARQ | STLDKEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.1012

SMR:

P04003

KEGG:

hsa:722

MIM:

120830

Pfam:

PF00084

String:

P04003

STRING:

9606.ENSP00000356037

Uniprot:

P04003

FOR

ELISA Kit for Human C4bp

Cat.:

E0761h

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Packing:

96T

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ELISA Kit for Human C4bp

Cat.:

E0761r

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Manual:

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Packing:

96T

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ELISA Kit for Human C4bp

Cat.:

E0761m

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MSDS:

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Packing:

96T

ELISA Kit for Human C4bp

Cat.:

E0761b

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MSDS:

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Packing:

96T

CLIA Kit for Human C4bp

Cat.:

U0761m

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MSDS:

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Packing:

96T

CLIA Kit for Human C4bp

Cat.:

U0761h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Human C4bp

Cat.:

U0761b

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Packing:

96T

CLIA Kit for Human C4bp

Cat.:

U0761r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human C4bp

Cat.:

P0761Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human C4bp

Cat.:

P0761Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human C4bp

Cat.:

P0761Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human C4bp

Monoclonal Antibody for Human C4bp

Protein for Human C4bp

Cat.:

R0761h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human C4bp

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Circulation levels of acute phase proteins in patients with Takayasu arteritis"

J Ma, X Luo, Q Wu, et al.

From:JOURNAL OF VASCULAR SURGERY

References

1.

"Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein."
Matsuguchi T. , Okamura S. , Aso T. , Sata T. , Niho Y.
Biochem. Biophys. Res. Commun.165:138-144(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
2.

"Genomic organization of the alpha chain of the human C4b-binding protein gene."
Aso T. , Okamura S. , Matsuguchi T. , Sakamoto N. , Sata T. , Niho Y.
Biochem. Biophys. Res. Commun.174:222-227(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
4.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
6.

"Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence."
Lintin S.J. , Lewin A.R. , Reid K.B.M.
FEBS Lett.232:328-332(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-81
7.

"Studies on the structure of the human C4b-binding protein gene."
Lintin S.J. , Reid K.B.M.
FEBS Lett.204:77-81(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 203-288
8.

"Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system."
Chung L.P. , Bentley D.R. , Reid K.B.M.
Biochem. J.230:133-141(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-597
9.

"Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment."
Chung L.P. , Gagnon J. , Reid K.B.M.
Mol. Immunol.22:427-435(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 49-88
10.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-506 AND ASN-528
tissue: Plasma.
11.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221 AND ASN-506
tissue: Plasma.
12.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221 AND ASN-506
tissue: Liver.
13.

"Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b."
Dahlback B. , Smith C.A. , Mueller-Eberhard H.J.
Proc. Natl. Acad. Sci. U.S.A.80:3461-3465(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY;LIGAND-BINDING
14.

"Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor."
Jenkins H.T. , Mark L. , Ball G. , Persson J. , Lindahl G. , Uhrin D. , Blom A.M. , Barlow P.N.
J. Biol. Chem.281:3690-3697(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 49-172;DISULFIDE BONDS

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