CASP9 ELISA Kit for Human(Homo sapiens) | EIAab.comCASP9 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CASP9(Gene name) > Human

CASP9 (Gene name),

Caspase-9 (Protein name ), CASP9_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CASP9(MCH6);

Protein name:

Caspase-9(CASP-9);

Alternative:

Apoptotic protease-activating factor 3(APAF-3);Apoptotic protease Mch-6;ICE-like apoptotic protease 6(ICE-LAP6);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 35 kDa (p35) and a 10 kDa (p10) subunit. Caspase-9 and APAF1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome C and ATP. Interacts with the inhibitors BIRC2, BIRC4, BIRC5 and BIRC7. Interacts (inactive form) with EFHD2. Interacts with HAX1.

Function:

Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

416

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

416:

PGCFNFLRKK | LFFKTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P55211

STRING:

9606.ENSP00000330237

KEGG:

hsa:842

String:

P55211

Pfam:

PF00619

UniGene:

Hs.329502

MIM:

602234

Uniprot:

P55211

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ELISA Kit for Human CASP-9

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E0627h

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Manual:

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96T

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ELISA Kit for Human CASP-9

Cat.:

E0627m

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96T

CLIA Kit for Human CASP-9

Cat.:

U0627m

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96T

CLIA Kit for Human CASP-9

Cat.:

U0627h

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96T

Polyclonal Antibody for Human CASP-9

Cat.:

P0627Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human CASP-9

Cat.:

P0627Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human CASP-9

Protein for Human CASP-9

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B."
Duan H. , Orth K. , Chinnaiyan A.M. , Poirier G.G. , Froelich C.J. , He W.-W. , Dixit V.M.
J. Biol. Chem.271:16720-16724(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-28 AND ARG-221
2.

"The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32."
Srinivasula S.M. , Fernandes-Alnemri T. , Zangrilli J. , Robertson N. , Armstrong R.C. , Wang L. , Trapani J.A. , Tomaselli K.J. , Litwack G. , Alnemri E.S.
J. Biol. Chem.271:27099-27106(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEOLYTIC PROCESSING
tissue: T-cell.
3.

"Genomic organization of the human caspase-9 gene on chromosome 1p36.1-p36.3."
Hadano S. , Nasir J. , Nichol K. , Rasper D.M. , Vaillancourt J.P. , Sherer S.W. , Beatty B.G. , Ikeda J.E. , Nicholson D.W. , Hayden M.R.
Mamm. Genome10:757-760(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Identification of an endogenous dominant-negative short isoform of caspase-9 that can regulate apoptosis."
Srinivasula S.M. , Ahmad M. , Guo Y. , Zhan Y. , Lazebnik Y. , Fernandes-Alnemri T. , Alnemri E.S.
Cancer Res.59:999-1002(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.

"Molecular cloning and sequencing of a cDNA predicting an alternative form of pro-caspase-9 from human gastric cancer cell lines."
Izawa M. , Mori T. , Ito H. , Sairenji T.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Stomach cancer.
6.

"A novel splicing product of human caspase-9 lacking protease activity."
Miho Y. , Momoi T. , Fujita E.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
7.

"A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis."
Seol D.W. , Billiar T.R.
J. Biol. Chem.274:2072-2076(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT VAL-28
8.

"Cloning of a novel human caspase-9 splice variant containing only the CARD domain."
Wang P. , Shi T. , Ma D.
Life Sci.79:934-940(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANT VAL-28
9.

NIEHS SNPs program
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-28; LEU-99; ILE-102; VAL-106; ASP-114; HIS-173 AND ARG-221
10.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
11.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Kidney.
12.

"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Eye.
tissue: Lymph.
15.

"Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK."
Allan L.A. , Morrice N. , Brady S. , Magee G. , Pathak S. , Clarke P.R.
Nat. Cell Biol.5:647-654(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-125
16.

"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase."
Bartke T. , Pohl C. , Pyrowolakis G. , Jentsch S.
Mol. Cell14:801-811(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BIRC6/BRUCE
17.

"c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage."
Raina D. , Pandey P. , Ahmad R. , Bharti A. , Ren J. , Kharbanda S. , Weichselbaum R. , Kufe D.
J. Biol. Chem.280:11147-11151(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;INTERACTION WITH ABL1;PROTEOLYTIC PROCESSING;PHOSPHORYLATION AT TYR-153 BY ABL1;MUTAGENESIS OF TYR-153
18.

"Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition."
Han Y. , Chen Y.S. , Liu Z. , Bodyak N. , Rigor D. , Bisping E. , Pu W.T. , Kang P.M.
Circ. Res.99:415-423(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HAX1;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-125; SER-302 AND SER-307;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells."
Checinska A. , Giaccone G. , Rodriguez J.A. , Kruyt F.A.E. , Jimenez C.R.
J. Proteomics72:575-585(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EFHD2
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Dimer formation drives the activation of the cell death protease caspase 9."
Renatus M. , Stennicke H.R. , Scott F.L. , Liddington R.C. , Salvesen G.S.
Proc. Natl. Acad. Sci. U.S.A.98:14250-14255(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 140-416;SUBUNIT
23.

"Mechanism of XIAP-mediated inhibition of caspase-9."
Shiozaki E.N. , Chai J. , Rigotti D.J. , Riedl S.J. , Li P. , Srinivasula S.M. , Alnemri E.S. , Fairman R. , Shi Y.
Mol. Cell11:519-527(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 140-416 IN COMPLEX WITH BIRC4/XIAP
24.

"The E.coli effector protein NleF is a caspase inhibitor."
Blasche S. , Moertl M. , Steuber H. , Siszler G. , Nisa S. , Schwarz F. , Lavrik I. , Gronewold T.M.A. , Maskos K. , Donnenberg M.S. , Ullmann D. , Uetz P. , Koegl M.
PLoS ONE0:0-0(2013)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.49 ANGSTROMS) OF 140-416 IN COMPLEX WITH E.COLI NLEF;INTERACTION WITH E.COLI NLEF;SUBUNIT;CATALYTIC ACTIVITY;FUNCTION;ENZYME REGULATION

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