CBX4 ELISA Kit for Human(Homo sapiens) | EIAab.comCBX4 ELISA Kit for Human(Homo sapiens)

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CBX4 (Gene name),

E3 SUMO-protein ligase CBX4 (Protein name ), CBX4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CBX4;

Protein name:

E3 SUMO-protein ligase CBX4;

Alternative:

Polycomb 2 homolog(Pc2;hPc2);Chromobox protein homolog 4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with histone H3-K9Me3 (By similarity). Component of a PRC1-like complex. Self-associates. Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B.

Function:

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

560

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

560:

TVTFKEYVTV |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.405046

SMR:

O00257

STRING:

9606.ENSP00000269397

Pfam:

PF00385

KEGG:

hsa:8535

String:

O00257

MIM:

603079

Uniprot:

O00257

FOR

ELISA Kit for Human E3 SUMO-protein ligase CBX4

CLIA Kit for Human E3 SUMO-protein ligase CBX4

Polyclonal Antibody for Human E3 SUMO-protein ligase CBX4

Monoclonal Antibody for Human E3 SUMO-protein ligase CBX4

Protein for Human E3 SUMO-protein ligase CBX4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis."
Satijn D.P.E. , Olson D.J. , van der Vlag J. , Hamer K.M. , Lambrechts C. , Masselink H. , Gunster M.J. , Sewalt R.G.A.B. , van Driel R. , Otte A.P.
Mol. Cell. Biol.17:6076-6086(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal brain.
2.

"Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment."
Salichs E. , Ledda A. , Mularoni L. , Alba M.M. , de la Luna S.
PLoS Genet.5:E1000397-E1000397(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
3.

"Cloning and identification of NS5ATP1-binding protein 16."
Liu M. , Cheng J. , Wang L.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon.
6.

"RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor."
Satijn D.P.E. , Gunster M.J. , van der Vlag J. , Hamer K.M. , Schul W. , Alkema M.J. , Saurin A.J. , Freemont P.S. , van Driel R. , Otte A.P.
Mol. Cell. Biol.17:4105-4113(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 457-560 (ISOFORM 1)
7.

"Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb group proteins."
Sewalt R.G.A.B. , Lachner M. , Vargas M. , Hamer K.M. , den Blaauwen J.L. , Hendrix T. , Melcher M. , Schweizer D. , Jenuwein T. , Otte A.P.
Mol. Cell. Biol.22:5539-5553(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUV39H1
8.

"The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans."
Levine S.S. , Weiss A. , Erdjument-Bromage H. , Shao Z. , Tempst P. , Kingston R.E.
Mol. Cell. Biol.22:6070-6078(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A PRC1-LIKE HPRC-H COMPLEX WITH BMI1; CBX2; CBX8; PHC1; PHC2; PHC3; RING1 AND RNF2
9.

"The polycomb protein Pc2 is a SUMO E3."
Kagey M.H. , Melhuish T.A. , Wotton D.
Cell113:127-137(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUMOYLATION;SUBCELLULAR LOCATION
10.

"Multiple activities contribute to Pc2 E3 function."
Kagey M.H. , Melhuish T.A. , Powers S.E. , Wotton D.
EMBO J.24:108-119(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-494
11.

"Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin."
Long J. , Zuo D. , Park M.
J. Biol. Chem.280:35477-35489(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Phosphorylation-dependent control of Pc2 SUMO E3 ligase activity by its substrate protein HIPK2."
Roscic A. , Moeller A. , Calzado M.A. , Renner F. , Wimmer V.C. , Gresko E. , Luedi K.S. , Schmitz M.L.
Mol. Cell24:77-89(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH HIPK2;SUMOYLATION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-497
13.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
14.

"Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus."
Maertens G.N. , El Messaoudi-Aubert S. , Racek T. , Stock J.K. , Nicholls J. , Rodriguez-Niedenfuhr M. , Gil J. , Peters G.
PLoS ONE4:E6380-E6380(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A PRC1-LIKE COMPLEX
15.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-149;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
16.

"Interaction proteomics analysis of polycomb proteins defines distinct PRC1 Complexes in mammalian cells."
Vandamme J. , Volkel P. , Rosnoblet C. , Le Faou P. , Angrand P.O.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY (ISOFORM 2);IDENTIFICATION IN A PRC1-LIKE COMPLEX;SELF-ASSOCIATION;SUBCELLULAR LOCATION;MUTAGENESIS OF SER-434
17.

"Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling."
Oh Y. , Chung K.C.
J. Biol. Chem.287:17517-17529(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ZNF131 SUMOYLATION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-494 AND THR-497
18.

"DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation."
Pelisch F. , Pozzi B. , Risso G. , Munoz M.J. , Srebrow A.
J. Biol. Chem.287:30789-30799(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
19.

"Solution NMR structure of the chromo domain of the chromobox protein homolog 4."
Structural genomics consortium (SGC)
Submitted (2009-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 8-65
20.

"Crystal structure of human chromobox homolog 4 (cbx4)."
Structural genomics consortium (SGC)
Submitted (2009-09) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 8-62

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