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Index > Protein center > CD28(Gene name) > Human
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  • CD28 (Gene name),
  • T-cell-specific surface glycoprotein CD28 (Protein name ),  CD28_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD28;
    Protein name:
    T-cell-specific surface glycoprotein CD28;
    Alternative:
    TP44;
    CD:
    CD28;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
    Function:
    Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    220
    Sequence:
    50:
    MLRLLLALNL | FPSIQVTGNK | ILVKQSPMLV | AYDNAVNLSC | KYSYNLFSRE | 
    100:
    FRASLHKGLD | SAVEVCVVYG | NYSQQLQVYS | KTGFNCDGKL | GNESVTFYLQ | 
    150:
    NLYVNQTDIY | FCKIEVMYPP | PYLDNEKSNG | TIIHVKGKHL | CPSPLFPGPS | 
    200:
    KPFWVLVVVG | GVLACYSLLV | TVAFIIFWVR | SKRSRLLHSD | YMNMTPRRPG | 
    220:
    PTRKHYQPYA | PPRDFAAYRS | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    Pfam:
    SMR:
    String:
    UniGene:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    E0652h
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    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    E0652r
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    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    E0652m
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    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    E0652b
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    ELISA Kit for Human T-cell-specific surface glycoprotein CD28
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    E0652c
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    Packing:
    96T
    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    U0652b
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    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    U0652c
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    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    U0652h
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    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    U0652m
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    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    CLIA Kit for Human T-cell-specific surface glycoprotein CD28
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    U0652r
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    Packing:
    96T
    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Cat.:
    P0652Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Cat.:
    P0652Rb-h
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    Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Cat.:
    P0652Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28
    Protein for Human T-cell-specific surface glycoprotein CD28

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    References
    1. 1.
      "Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system."
      Aruffo A. , Seed B.
      Proc. Natl. Acad. Sci. U.S.A.84:8573-8577(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The genomic organization of the CD28 gene. Implications for the regulation of CD28 mRNA expression and heterogeneity."
      Lee K.P. , Taylor C. , Petryniak B. , Turka L.A. , June C.H. , Thompson C.B.
      J. Immunol.145:344-352(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3);ALTERNATIVE SPLICING
    3. 3.
      "A novel CD28 mRNA variant and simultaneous presence of various CD28 mRNA isoforms in human T lymphocytes."
      Deshpande M. , Venuprasad K. , Parab P.B. , Saha B. , Mitra D.
      Hum. Immunol.63:20-23(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    4. 4.
      "A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28."
      Hanawa H. , Ma Y. , Mikolajczak S.A. , Charles M.L. , Yoshida T. , Yoshida R. , Strathdee C.A. , Litchfield D.W. , Ochi A.
      Blood99:2138-2145(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 6);CHARACTERIZATION (ISOFORM 3)
      tissue: Peripheral blood T-cell.
    5. 5.
      "New human CD28 isoforms generated by a novel splicing event in the 5'UTR."
      Gan S.U. , Hare J. , Krivoshchapov L. , Hui K.M. , Galea-Lauri J. , Farzaneh F. , Darling D.
      Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7)
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Synovium.
      tissue: Trachea.
    8. 8.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    11. 11.
      "Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
      Ling V. , Wu P.W. , Finnerty H.F. , Agostino M.J. , Graham J.R. , Chen S. , Jussiff J.M. , Fisk G.J. , Miller C.P. , Collins M.
      Genomics78:155-168(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-178 (ISOFORM 1)
    12. 12.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71 AND ASN-129
      tissue: Leukemic T-cell.
    14. 14.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND TYR-191;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-152 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY;DISULFIDE BONDS;GLYCOSYLATION AT ASN-37 AND ASN-105
    16. 16.
      "High resolution crystal structure of the Grb2 SH2 domain with a phosphopeptide derived from CD28."
      Higo K. , Ikura T. , Oda M. , Morii H. , Takahashi J. , Abe R. , Ito N.
      PLoS ONE8:E74482-E74482(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 189-196 IN COMPLEX WITH GRB2;INTERACTION WITH GRB2
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