Protein name:
T-cell-specific surface glycoprotein CD28 ;
Alternative:
TP44 ;
CD:
CD28 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70.
Function:
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MLRLLLALNL | FPSIQVTGNK | ILVKQSPMLV | AYDNAVNLSC | KYSYNLFSRE |
100:
FRASLHKGLD | SAVEVCVVYG | NYSQQLQVYS | KTGFNCDGKL | GNESVTFYLQ |
150:
NLYVNQTDIY | FCKIEVMYPP | PYLDNEKSNG | TIIHVKGKHL | CPSPLFPGPS |
200:
KPFWVLVVVG | GVLACYSLLV | TVAFIIFWVR | SKRSRLLHSD | YMNMTPRRPG |
220:
PTRKHYQPYA | PPRDFAAYRS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Rat
Mouse
Bovine
Chicken
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
ELISA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
CLIA Kit for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Polyclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Monoclonal Antibody for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
Protein for Human T-cell-specific surface glycoprotein CD28
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 3);ALTERNATIVE SPLICING
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 4 AND 6);CHARACTERIZATION (ISOFORM 3)
tissue :
Peripheral blood T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7)
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more...
Nat. Genet.36:40-45(2004)
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Synovium .
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Trachea .
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Nature434:724-731(2005)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Mural R.J.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
11.
"Assembly and annotation of human chromosome 2q33 sequence containing the CD28, CTLA4, and ICOS gene cluster: analysis by computational, comparative, and microarray approaches."
Ling V.
,
Wu P.W.
,
Finnerty H.F.
,
Agostino M.J.
,
Graham J.R.
,
Chen S.
,
Jussiff J.M.
,
Fisk G.J.
,
Miller C.P.
,
Collins M.
Genomics78:155-168(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-178 (ISOFORM 1)
12.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
13.
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Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-71 AND ASN-129
tissue :
Leukemic T-cell .
14.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189 AND TYR-191;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
15.
"Crystal structure of a soluble CD28-Fab complex."
Evans E.J.
,
Esnouf R.M.
,
Manso-Sancho R.
,
Gilbert R.J.
,
James J.R.
,
Yu C.
,
Fennelly J.A.
,
Vowles C.
,
Hanke T.
,
Walse B.
,
Hunig T.
,
Sorensen P.
,
Stuart D.I.
,
Davis S.J.
Nat. Immunol.6:271-279(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-152 IN COMPLEX WITH THE FAB FRAGMENT OF A MITOGENIC ANTIBODY;DISULFIDE BONDS;GLYCOSYLATION AT ASN-37 AND ASN-105
16.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 189-196 IN COMPLEX WITH GRB2;INTERACTION WITH GRB2