Gene name:
CD44 (LHR;MDU2;MDU3;MIC4) ;
Protein name:
CD44 antigen ;
Alternative:
Phagocytic glycoprotein I (PGP-I) ;Epican ;CDw44 ;GP90 lymphocyte homing/adhesion receptor ;Extracellular matrix receptor III (ECMR-III) ;Heparan sulfate proteoglycan ;HUTCH-I ;Hyaluronate receptor ;Hermes antigen ;Phagocytic glycoprotein 1 (PGP-1) ;
CD:
CD44 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
Function:
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MDKFWWHAAW | GLCLVPLSLA | QIDLNITCRF | AGVFHVEKNG | RYSISRTEAA |
100:
DLCKAFNSTL | PTMAQMEKAL | SIGFETCRYG | FIEGHVVIPR | IHPNSICAAN |
150:
NTGVYILTSN | TSQYDTYCFN | ASAPPEEDCT | SVTDLPNAFD | GPITITIVNR |
200:
DGTRYVQKGE | YRTNPEDIYP | SNPTDDDVSS | GSSSERSSTS | GGYIFYTFST |
250:
VHPIPDEDSP | WITDSTDRIP | ATTLMSTSAT | ATETATKRQE | TWDWFSWLFL |
300:
PSESKNHLHT | TTQMAGTSSN | TISAGWEPNE | ENEDERDRHL | SFSGSGIDDD |
350:
EDFISSTIST | TPRAFDHTKQ | NQDWTQWNPS | HSNPEVLLQT | TTRMTDVDRN |
400:
GTTAYEGNWN | PEAHPPLIHH | EHHEEEETPH | STSTIQATPS | STTEETATQK |
450:
EQWFGNRWHE | GYRQTPKEDS | HSTTGTAAAS | AHTSHPMQGR | TTPSPEDSSW |
500:
TDFFNPISHP | MGRGHQAGRR | MDMDSSHSIT | LQPTANPNTG | LVEDLDRTGP |
550:
LSMTTQQSNS | QSFSTSHEGL | EEDKDHPTTS | TLTSSNRNDV | TGGRRDPNHS |
600:
EGSTTLLEGY | TSHYPHTKES | RTFIPVTSAK | TGSFGVTAVT | VGDSNSNVNR |
650:
SLSGDQDTFH | PSGGSHTTHG | SESDGHSHGS | QEGGANTTSG | PIRTPQIPEW |
700:
LIILASLLAL | ALILAVCIAV | NSRRRCGQKK | KLVINSGNGA | VEDRKPSGLN |
742:
GEASKSQEMV | HLVNKESSET | PDQFMTADET | RNLQNVDMKI | GV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
Dog
ELISA Kit for Human CD44 antigen
ELISA Kit for Human CD44 antigen
ELISA Kit for Human CD44 antigen
ELISA Kit for Human CD44 antigen
ELISA Kit for Human CD44 antigen
CLIA Kit for Human CD44 antigen
CLIA Kit for Human CD44 antigen
CLIA Kit for Human CD44 antigen
CLIA Kit for Human CD44 antigen
CLIA Kit for Human CD44 antigen
Polyclonal Antibody for Human CD44 antigen
Polyclonal Antibody for Human CD44 antigen
Polyclonal Antibody for Human CD44 antigen
Polyclonal Antibody for Human CD44 antigen
Polyclonal Antibody for Human CD44 antigen
Monoclonal Antibody for Human CD44 antigen
Monoclonal Antibody for Human CD44 antigen
Monoclonal Antibody for Human CD44 antigen
Monoclonal Antibody for Human CD44 antigen
Monoclonal Antibody for Human CD44 antigen
Protein for Human CD44 antigen
Protein for Human CD44 antigen
Protein for Human CD44 antigen
Protein for Human CD44 antigen
Protein for Human CD44 antigen
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12)
tissue :
Reticulocyte .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 10);VARIANT THR-479
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 11);VARIANT THR-479
tissue :
Myeloid leukemia cell .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);VARIANT THR-479
tissue :
Keratinocyte .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING;VARIANTS ARG-417 AND THR-479
tissue :
Lymphoblast .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-417; THR-479 AND HIS-494
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 13 AND 14);VARIANT THR-479
tissue :
Mammary carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 19)
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 12)
tissue :
Articular cartilage .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 10 AND 12);VARIANT THR-479
tissue :
Colon adenocarcinoma .
tissue :
Retinal pigment epithelium .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11)
13.
"Construction of human CD44 eukaryotic vector and its expression in mammary carcinoma cells MCF-7."
Fang X.
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Submitted (2008-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 18)
14.
"The full-ORF clone resource of the German cDNA consortium."
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BMC Genomics8:399-399(2007)
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Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 12)
tissue :
Spinal cord .
15.
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D.
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Noguchi H.
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Toyoda A.
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Lander E.S.
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more...
Nature440:497-500(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
16.
Mural R.J.
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more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 12);VARIANTS ARG-417 AND THR-479
tissue :
Pancreas .
tissue :
Retinal pigment epithelium .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-22
tissue :
Lymphoblast .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 2-742 (ISOFORM 15)
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 55-108
tissue :
Glial tumor .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 67-89
tissue :
Peripheral blood .
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 184-625 (ISOFORM 10);VARIANT THR-479
tissue :
Foreskin .
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 221-267
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 267-603 (ISOFORM 1);VARIANT ARG-417
tissue :
Lung .
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION;POST-TRANSLATIONAL MODIFICATIONS
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-706
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-672
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION;PROTEOLYTIC PROCESSING
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57
tissue :
Plasma .
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-706;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
T-cell .
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57 AND ASN-110
tissue :
Liver .
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UNC119
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
38.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-686 AND SER-706;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
40.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT THR-637 AND THR-638;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
41.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-706;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
42.
"Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44."
Teriete P.
,
Banerji S.
,
Noble M.
,
Blundell C.D.
,
Wright A.J.
,
Pickford A.R.
,
Lowe E.
,
Mahoney D.J.
,
Tammi M.I.
,
Kahmann J.D.
,
Campbell I.D.
,
Day A.J.
,
Jackson D.G.
Mol. Cell13:483-496(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 20-178;STRUCTURE BY NMR OF 20-178;INTERACTION WITH HA
43.
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Cited for : STRUCTURE BY NMR OF 20-178 IN COMPLEX WITH HA
44.
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Cited for : VARIANT BLOOD GROUP INDIAN PRO-46