CD86 ELISA Kit for Human(Homo sapiens) | EIAab.comCD86 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CD86(Gene name) > Human

CD86 (Gene name),

T-lymphocyte activation antigen CD86 (Protein name ), CD86_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD86(CD28LG2);

Protein name:

T-lymphocyte activation antigen CD86;

Alternative:

B70;Activation B7-2 antigen;CTLA-4 counter-receptor B7.2;BU63;FUN-1;

CD:

CD86;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

Function:

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

329

Sequence:

50:

100:

150:

200:

250:

300:

329:

IHIPERSDEA | QRVFKSSKTS | SCDKSDTCF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

String:

P42081

STRING:

9606.ENSP00000332049

MIM:

601020

KEGG:

hsa:942

UniGene:

Hs.171182

SMR:

P42081

Uniprot:

P42081

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ELISA Kit for Human T-lymphocyte activation antigen CD86

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E0824m

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96T

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ELISA Kit for Human T-lymphocyte activation antigen CD86

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ELISA Kit for Human T-lymphocyte activation antigen CD86

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E0824h

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96T

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CLIA Kit for Human T-lymphocyte activation antigen CD86

Cat.:

U0824h

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Looking for manual.

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96T

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CLIA Kit for Human T-lymphocyte activation antigen CD86

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CLIA Kit for Human T-lymphocyte activation antigen CD86

Cat.:

U0824m

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96T

Polyclonal Antibody for Human T-lymphocyte activation antigen CD86

Cat.:

P0824Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human T-lymphocyte activation antigen CD86

Cat.:

P0824Rb-h

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human T-lymphocyte activation antigen CD86

Protein for Human T-lymphocyte activation antigen CD86

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"B70 antigen is a second ligand for CTLA-4 and CD28."
Azuma M. , Ito D. , Yagita K. , Okumura K. , Phillips J.H. , Lanier L.L. , Somoza C.
Nature366:76-79(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANT ILE-185
2.

"Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation."
Freeman G.J. , Gribben J.G. , Boussiotis V.A. , Ng J.W. , Restivo V.A. Jr. , Lombard L.A. , Gray G.S. , Nadler L.M.
Science262:909-911(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-185
3.

"Identification of an alternatively spliced variant of human CD86 mRNA."
Magistrelli G. , Caron G. , Gauchat J.-F. , Jeannin P. , Bonnefoy J.-Y. , Delneste Y.
Biochem. Biophys. Res. Commun.280:1211-1215(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4);VARIANT ILE-185
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ILE-185
5.

Livingston R.J. , Shaffer T. , McFarland I. , Nguyen C.P. , Stanaway I.B. , Rajkumar N. , Johnson E.J. , da Ponte S.H. , Willa H. , Ahearn M.O. , Bertucci C. , Acklestad J. , Carroll A. , Swanson J. , Gildersleeve H.I. , Nickerson D.A.
Submitted (2006-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-185
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5);VARIANTS ILE-185 AND THR-310
tissue: Brain.
7.

"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ILE-185 AND THR-310
tissue: Brain.
9.

"Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86)."
Jellis C.L. , Wang S.S. , Rennert P. , Borriello F. , Sharpe A.H. , Green N.R. , Gray G.S.
Immunogenetics42:85-89(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 7-329;VARIANT ILE-185
tissue: Foreskin.
10.

"CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL."
Lanier L.L. , O'Fallon S. , Somoza C. , Phillips J.H. , Linsley P.S. , Okumura K. , Ito D. , Azuma M.
J. Immunol.154:97-105(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
11.

"The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen."
Engel P. , Gribben J.G. , Freeman G.J. , Zhou L.J. , Nozawa Y. , Abe M. , Nadler L.M. , Wakasa H. , Tedder T.F.
Blood84:1402-1407(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION AS CD86
12.

"c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity."
Goto E. , Ishido S. , Sato Y. , Ohgimoto S. , Ohgimoto K. , Nagano-Fujii M. , Hotta H.
J. Biol. Chem.278:14657-14668(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH MARCH8
13.

"Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors."
Short J.J. , Vasu C. , Holterman M.J. , Curiel D.T. , Pereboev A.
Virus Res.122:144-153(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ADENOVIRUS SUBGROUP B FIBER PROTEINS
14.

"Structural basis for co-stimulation by the human CTLA-4/B7-2 complex."
Schwartz J.C. , Zhang X. , Fedorov A.A. , Nathenson S.G. , Almo S.C.
Nature410:604-608(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF 26-134 IN COMPLEX WITH CTLA4
15.

"Crystal structure of the receptor-binding domain of human B7-2: insights into organization and signaling."
Zhang X. , Schwartz J.C. , Almo S.C. , Nathenson S.G.
Proc. Natl. Acad. Sci. U.S.A.100:2586-2591(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 26-134;SUBUNIT;DISULFIDE BOND

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