C3 ELISA Kit for Human(Homo sapiens) | EIAab.comC3 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > C3(Gene name) > Human

C3 (Gene name),

Complement C3 (Protein name ), CO3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

C3(CPAMD1);

Protein name:

Complement C3;

Alternative:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain). C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). During pregnancy, C3dg exists as a complex (probably a 2:2:2 heterohexamer) with AGT and the proform of PRG2. Interacts with VSIG4. C3b interacts with herpes simplex virus 1 (HHV-1) and herpes simplex virus 2 (HHV-2) envelope glycoprotein C; this interaction inhibits the activation of the complement system. Interacts with S.aureus immunoglobulin-binding protein sbi, this prevents interaction between C3dg and CR2. Interacts with S.aureus fib.

Function:

Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

1663

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1650:

1663:

AFTESMVVFG | CPN

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00207

STRING:

9606.ENSP00000245907

SMR:

P01024

UniGene:

Hs.529053

String:

P01024

KEGG:

hsa:718

MIM:

120700

Uniprot:

P01024

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ELISA Kit for Human Complement C3

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E0861h

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96T

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ELISA Kit for Human Complement C3

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E0861m

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96T

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ELISA Kit for Human Complement C3

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ELISA Kit for Human Complement C3

Cat.:

E0861r

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96T

ELISA Kit for Human Complement C3

Cat.:

E0861b

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96T

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ELISA Kit for Human Complement C3

MSDS:

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CLIA Kit for Human Complement C3

Cat.:

U0861b

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96T

CLIA Kit for Human Complement C3

MSDS:

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CLIA Kit for Human Complement C3

Cat.:

U0861r

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96T

CLIA Kit for Human Complement C3

MSDS:

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CLIA Kit for Human Complement C3

Cat.:

U0861m

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Looking for manual.

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96T

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CLIA Kit for Human Complement C3

Cat.:

U0861h

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96T

Polyclonal Antibody for Human Complement C3

Cat.:

P0861Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Complement C3

Cat.:

P0861Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Complement C3

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P0861Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Complement C3

Protein for Human Complement C3

Cat.:

R0861h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human Complement C3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Human complement component C3: cDNA coding sequence and derived primary structure."
de Bruijn M.H.L. , Fey G.H.
Proc. Natl. Acad. Sci. U.S.A.82:708-712(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-314
2.

SeattleSNPs variation discovery resource
Submitted (2003-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-102; LEU-314; LYS-863; ASP-1224 AND THR-1367
3.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis."
Baldo A. , Sniderman A.D. , St-Luce S. , Avramoglu R.K. , Maslowska M. , Hoang B. , Monge J.C. , Bell A. , Mulay S. , Cianflone K.
J. Clin. Invest.92:1543-1547(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF N-TERMINUS;IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
6.

"Human anaphylatoxin (C3a) from the third component of complement. Primary structure."
Hugli T.E.
J. Biol. Chem.250:8293-8301(1975) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 672-748
7.

"Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma."
Oxvig C. , Haaning J. , Kristensen L. , Wagner J.M. , Rubin I. , Stigbrand T. , Gleich G.J. , Sottrup-Jensen L.
J. Biol. Chem.270:13645-13651(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 955-966;SUBUNIT
tissue: Serum.
8.

"Third component of human complement: localization of the internal thiolester bond."
Thomas M.L. , Janatova J. , Gray W.R. , Tack B.F.
Proc. Natl. Acad. Sci. U.S.A.79:1054-1058(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 988-1036
9.

"A 34-amino acid peptide of the third component of complement mediates properdin binding."
Daoudaki M.E. , Becherer J.D. , Lambris J.D.
J. Immunol.140:1577-1580(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1409-1563
10.

"Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2."
Eisenberg R.J. , Ponce de Leon M. , Friedman H.M. , Fries L.F. , Frank M.M. , Hastings J.C. , Cohen G.H.
Microb. Pathog.3:423-435(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HERPES SIMPLEX VIRUS HHV-1 AND HHV-2 GYCOPROTEIN C
11.

"Purification and characterization of acylation stimulating protein."
Cianflone K.M. , Sniderman A.D. , Walsh M.J. , Vu H.T. , Gagnon J. , Rodriguez M.A.
J. Biol. Chem.264:426-430(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3."
Isaac L. , Isenman D.E.
J. Biol. Chem.267:10062-10069(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THE THIOESTER BOND REGION
13.

"Disulfide bridges in human complement component C3b."
Dolmer K. , Sottrup-Jensen L.
FEBS Lett.315:85-90(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
14.

"Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line."
Tao Y. , Cianflone K. , Sniderman A.D. , Colby-Germinario S.P. , Germinario R.J.
Biochim. Biophys. Acta1344:221-229(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period."
Saleh J. , Summers L.K. , Cianflone K. , Fielding B.A. , Sniderman A.D. , Frayn K.N.
J. Lipid Res.39:884-891(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;TISSUE SPECIFICITY;FUNCTION
16.

"Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity."
Murray I. , Kohl J. , Cianflone K.
Biochem. J.342:41-48(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
17.

"The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74)."
Cain S.A. , Monk P.N.
J. Biol. Chem.277:7165-7169(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C5AR2
18.

"The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein."
Kalant D. , Cain S.A. , Maslowska M. , Sniderman A.D. , Cianflone K. , Monk P.N.
J. Biol. Chem.278:11123-11129(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C5AR2
19.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-85
20.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-939
tissue: Plasma.
21.

"Acylation-stimulating protein: effect of acute exercise and endurance training."
Schrauwen P. , Hesselink M.K. , Jain M. , Cianflone K.
Int. J. Obes. Relat. Metab. Disord.29:632-638(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: EFFECTS OF EXERCISE
22.

"C5L2 is a functional receptor for acylation-stimulating protein."
Kalant D. , MacLaren R. , Cui W. , Samanta R. , Monk P.N. , Laporte S.A. , Cianflone K.
J. Biol. Chem.280:23936-23944(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
23.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85; ASN-939 AND ASN-1617
tissue: Plasma.
24.

"Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes."
Yang Y. , Lu H.L. , Zhang J. , Yu H.Y. , Wang H.W. , Zhang M.X. , Cianflone K.
Int. J. Obes. Relat. Metab. Disord.30:439-446(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH TYPE 2 DIABETES
25.

"Targeting the signaling pathway of acylation stimulating protein."
Maslowska M. , Legakis H. , Assadi F. , Cianflone K.
J. Lipid Res.47:643-652(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION
26.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85
tissue: Platelet.
27.

"Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents."
Wamba P.C. , Mi J. , Zhao X.Y. , Zhang M.X. , Wen Y. , Cheng H. , Hou D.Q. , Cianflone K.
Eur. J. Endocrinol.159:781-790(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH OBESITY
28.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-85
tissue: Liver.
29.

"C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation."
Cui W. , Simaan M. , Laporte S. , Lodge R. , Cianflone K.
Mol. Immunol.46:3086-3098(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure."
Isenman D.E. , Leung E. , Mackay J.D. , Bagby S. , van den Elsen J.M.
J. Immunol.184:1946-1955(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-1029; GLU-1030; GLU-1032; GLU-1035; ARG-1042; ASP-1140; GLU-1153; ASP-1156; GLU-1159; GLU-1160; ASN-1163 AND LYS-1284;INTERACTION WITH CR2 AND S.AUREUS SBI
31.

"Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking."
Shaw C.D. , Storek M.J. , Young K.A. , Kovacs J.M. , Thurman J.M. , Holers V.M. , Hannan J.P.
J. Mol. Biol.404:697-710(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-1029; GLU-1030; GLU-1032; GLU-1110; ASP-1115; ASP-1121; ASP-1140; GLU-1153; ASP-1156; GLU-1159; GLU-1160 AND ASN-1163;INTERACTION WITH CR2
32.

"Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population."
Onat A. , Hergenc G. , Can G. , Kaya Z. , Yuksel H.
Metabolism59:628-634(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH CORONARY HEART DISEASE
33.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
34.

"Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations."
Nettesheim D.G. , Edalji R.P. , Mollison K.W. , Greer J. , Zuiderweg E.R.P.
Proc. Natl. Acad. Sci. U.S.A.85:5036-5040(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF C3A
35.

"X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2."
Nagar B. , Jones R.G. , Diefenbach R.J. , Isenman D.E. , Rini J.M.
Science280:1277-1281(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF C3D
36.

"Structure of complement receptor 2 in complex with its C3d ligand."
Szakonyi G. , Guthridge J.M. , Li D. , Young K. , Holers V.M. , Chen X.S.
Science292:1725-1728(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF C3D IN COMPLEX WITH CR2;MUTAGENESIS OF 1108-ILE-LEU-1109 AND ASN-1163
37.

"Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study."
Gilbert H.E. , Eaton J.T. , Hannan J.P. , Holers V.M. , Perkins S.J.
J. Mol. Biol.346:859-873(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY SCATTERING SOLUTION STRUCTURE OF C3D IN COMPLEX WITH CR2
38.

"Structures of complement component C3 provide insights into the function and evolution of immunity."
Janssen B.J.C. , Huizinga E.G. , Raaijmakers H.C.A. , Roos A. , Daha M.R. , Nilsson-Ekdahl K. , Nilsson B. , Gros P.
Nature437:505-511(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF C3C;X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF C3
39.

"Structure of C3b reveals conformational changes that underlie complement activity."
Janssen B.J.C. , Christodoulidou A. , McCarthy A. , Lambris J.D. , Gros P.
Nature444:213-216(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF C3B
40.

"Structure of C3b in complex with CRIg gives insights into regulation of complement activation."
Wiesmann C. , Katschke K.J. , Yin J. , Helmy K.Y. , Steffek M. , Fairbrother W.J. , McCallum S.A. , Embuscado L. , DeForge L. , Hass P.E. , van Lookeren Campagne M.
Nature444:217-220(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF C3C IN COMPLEX WITH VSIG4;X-RAY CRYSTALLOGRAPHY (4.1 ANGSTROMS) OF C3B IN COMPLEX WITH VSIG4;GLYCOSYLATION AT ASN-85 AND ASN-939
41.

"Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition."
Janssen B.J. , Halff E.F. , Lambris J.D. , Gros P.
J. Biol. Chem.282:29241-29247(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 23-936 AND 1321-1663 IN COMPLEX WITH INHIBITOR COMPSTATIN;DISULFIDE BONDS;GLYCOSYLATION AT ASN-85
42.

"A structural basis for complement inhibition by Staphylococcus aureus."
Hammel M. , Sfyroera G. , Ricklin D. , Magotti P. , Lambris J.D. , Geisbrecht B.V.
Nat. Immunol.8:430-437(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 996-1287 IN COMPLEX WITH S.AUREUS FIB
43.

"A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d."
Clark E.A. , Crennell S. , Upadhyay A. , Zozulya A.V. , Mackay J.D. , Svergun D.I. , Bagby S. , van den Elsen J.M.
Mol. Immunol.48:452-462(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 996-1303 IN COMPLEX WITH S.AUREUS SBI;SUBUNIT
44.

"A crystal structure of the complex between human complement receptor 2 and its ligand C3d."
van den Elsen J.M. , Isenman D.E.
Science332:608-611(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.16 ANGSTROMS) OF 996-1303 IN COMPLEX WITH CR2;INTERACTION WITH CR2
45.

"The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3."
Poznansky M.C. , Clissold P.M. , Lachmann P.J.
J. Immunol.143:1254-1258(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3S ASN-1216
46.

Poznansky M.C. , Clissold P.M. , Lachmann P.J.
J. Immunol.143:3860-3862(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM;RETRACTION
47.

"Molecular basis of polymorphisms of human complement component C3."
Botto M. , Yong Fong K. , So A.K. , Koch C. , Walport M.J.
J. Exp. Med.172:1011-1017(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-102 AND LEU-314
48.

"Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion."
Singer L. , Whitehead W.T. , Akama H. , Katz Y. , Fishelson Z. , Wetsel R.A.
J. Biol. Chem.269:28494-28499(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3D ASN-549
49.

"A novel C3 allotype C3'F02'has an amino acid substitution that may inhibit iC3b synthesis and cause C3-hypocomplementemia."
Watanabe Y. , Matsui N. , Yan K. , Nishimukai H. , Tokunaga K. , Juji T. , Kobayashi N. , Kohsaka T.
Mol. Immunol.30:62-62(1993)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C3D GLN-1320
50.

"Complement C3 variant and the risk of age-related macular degeneration."
Yates J.R.W. , Sepp T. , Matharu B.K. , Khan J.C. , Thurlby D.A. , Shahid H. , Clayton D.G. , Hayward C. , Morgan J. , Wright A.F. , Armbrecht A.M. , Dhillon B. , Deary I.J. , Redmond E. , Bird A.C. , Moore A.T.
N. Engl. J. Med.357:553-561(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION OF VARIANT GLY-102 WITH ARMD9
51.

"Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome."
Fremeaux-Bacchi V. , Miller E.C. , Liszewski M.K. , Strain L. , Blouin J. , Brown A.L. , Moghal N. , Kaplan B.S. , Weiss R.A. , Lhotta K. , Kapur G. , Mattoo T. , Nivet H. , Wong W. , Gie S. , Hurault de Ligny B. , Fischbach M. , Gupta R. , more...
Blood112:4948-4952(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS5 GLN-592; TRP-592; TRP-735; VAL-1094; ASN-1115; TRP-1158; LYS-1161 AND ASP-1464;CHARACTERIZATION OF VARIANTS AHUS5 GLN-592; TRP-592; VAL-1094; ASN-1115 AND LYS-1161
52.

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS5 VAL-603 AND LEU-1042
53.

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-549;IDENTIFICATION BY MASS SPECTROMETRY
54.

"Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk."
Heurich M. , Martinez-Barricarte R. , Francis N.J. , Roberts D.L. , Rodriguez de Cordoba S. , Morgan B.P. , Harris C.L.
Proc. Natl. Acad. Sci. U.S.A.108:8761-8766(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT GLY-102
55.

"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration."
Seddon J.M. , Yu Y. , Miller E.C. , Reynolds R. , Tan P.L. , Gowrisankar S. , Goldstein J.I. , Triebwasser M. , Anderson H.E. , Zerbib J. , Kavanagh D. , Souied E. , Katsanis N. , Daly M.J. , Atkinson J.P. , Raychaudhuri S.
Nat. Genet.45:1366-1370(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARMD9 GLN-155;CHARACTERIZATION OF VARIANT ARMD9 GLN-155

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