C4A ELISA Kit for Human(Homo sapiens) | EIAab.comC4A ELISA Kit for Human(Homo sapiens)

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Index > Protein center > C4A(Gene name) > Human

C4A (Gene name),

Complement C4-A (Protein name ), CO4A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

C4A(CO4;CPAMD2);

Protein name:

Complement C4-A;

Alternative:

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2;Acidic complement C4;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Circulates in blood as a disulfide-linked trimer of an alpha, beta and gamma chain.

Function:

Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

1744

Sequence:

50:

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1550:

1600:

1650:

1700:

1744:

YLLDSNSWIE | EMPSERLCRS | TRQRAACAQL | NDFLQEYGTQ | GCQV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:720

Pfam:

PF00207

String:

P0C0L4

SMR:

P0C0L4

MIM:

120790

UniGene:

Hs.534847

STRING:

9606.ENSP00000364444

Uniprot:

P0C0L4

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ELISA Kit for Human Complement C4-A

Cat.:

E0389h

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96T

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CLIA Kit for Human Complement C4-A

Cat.:

U0389h

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Complement C4-A

Cat.:

P0389Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Complement C4-A

Protein for Human Complement C4-A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Circulation levels of acute phase proteins in patients with Takayasu arteritis"

J Ma, X Luo, Q Wu, et al.

From:JOURNAL OF VASCULAR SURGERY

References

1.

"The structural basis of the multiple forms of human complement component C4."
Belt K.T. , Carroll M.C. , Porter R.R.
Cell36:907-914(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ALA-418 AND SER-1201
tissue: Liver.
2.

"The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene."
Yu C.Y.
J. Immunol.146:1057-1066(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS TYR-347; LEU-726 AND ALA-1286
3.

"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
Nakajima D. , Saito K. , Yamakawa H. , Kikuno R.F. , Nakayama M. , Ohara R. , Okazaki N. , Koga H. , Nagase T. , Ohara O.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS SER-1176 AND ALA-1286
tissue: Brain.
4.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS TYR-347; SER-1176 AND ALA-1286
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS TYR-347; GLY-1073 AND ALA-1286
tissue: Brain.
6.

"Polymorphism of human complement component C4."
Belt K.T. , Yu C.Y. , Carroll M.C. , Porter R.R.
Immunogenetics21:173-180(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22 AND 1056-1225
7.

"Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex."
Sargent C.A. , Anderson M.J. , Hsieh S.-L. , Kendall E. , Gomez-Escobar N. , Campbell R.D.
Hum. Mol. Genet.3:481-488(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21;VARIANT ASN-727
8.

"Molecular genetics of complement C4: implications for MHC evolution and disease susceptibility gene mapping."
Sayer D. , Puschendorf M. , Wetherall J.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 448-570 AND 692-1225;VARIANTS TRP-477; PRO-549; THR-907; GLY-1073; SER-1176; ALA-1207 AND ARG-1210
9.

"Complete primary structure of human C4a anaphylatoxin."
Moon K.E. , Gorski J.P. , Hugli T.E.
J. Biol. Chem.256:8685-8692(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 680-756
10.

"Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein."
Hessing M. , van 't Veer C. , Hackeng T.M. , Bouma B.N. , Iwanaga S.
FEBS Lett.271:131-136(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 757-771 AND 980-990
11.

"Amino acid sequence around the thiol and reactive acyl groups of human complement component C4."
Campbell R.D. , Gagnon J. , Porter R.R.
Biochem. J.199:359-370(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 957-1044
12.

"The chemical structure of the C4d fragment of the human complement component C4."
Chakravarti D.N. , Campbell R.D. , Porter R.R.
Mol. Immunol.24:1187-1197(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 957-1336;VARIANTS GLY-1073; SER-1176; ALA-1207; ARG-1210 AND ALA-1286
13.

"Sequence determination of the thiolester site of the fourth component of human complement."
Harrison R.A. , Thomas M.L. , Tack B.F.
Proc. Natl. Acad. Sci. U.S.A.78:7388-7392(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 990-1037
14.

"C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination."
Martinez-Quiles N. , Paz-Artal E. , Moreno-Pelayo M.A. , Longas J. , Ferre-Lopez S. , Rosal M. , Arnaiz-Villena A.
J. Immunol.161:3438-3443(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1055-1225 (ALLOTYPE C4A13)
15.

"Cloning of a human complement component C4 gene."
Carroll M.C. , Porter R.R.
Proc. Natl. Acad. Sci. U.S.A.80:264-267(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1195-1294
16.

"Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4."
Chakravarti D.N. , Campbell R.D. , Gagnon J.
FEBS Lett.154:387-390(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1199-1304;VARIANTS ALA-1207; ARG-1210 AND ALA-1286
17.

"Identification of the site of sulfation of the fourth component of human complement."
Hortin G. , Sims H. , Strauss A.W.
J. Biol. Chem.261:1786-1793(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1405-1431;SULFATION AT TYR-1417; TYR-1420 AND TYR-1422
18.

"Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig."
Whitehead A.S. , Goldberger G. , Woods D.E. , Markham A.F. , Colten H.R.
Proc. Natl. Acad. Sci. U.S.A.80:5387-5391(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1448-1474
19.

"Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A."
Carroll M.C. , Fathallah D.M. , Bergamaschini L. , Alicot E.M. , Isenman D.E.
Proc. Natl. Acad. Sci. U.S.A.87:6868-6872(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INVOLVEMENT OF ASP-1125 IN IMMUNOGLOBULIN-BINDING AND HEMOLYSIS
20.

"Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression."
Barba G. , Rittner C. , Schneider P.M.
J. Clin. Invest.91:1681-1686(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN C4AD
21.

"The reaction mechanism of the internal thioester in the human complement component C4."
Dodds A.W. , Ren X.D. , Willis A.C. , Law S.K.
Nature379:177-179(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes."
Lokki M.L. , Circolo A. , Ahokas P. , Rupert K.L. , Yu C.Y. , Colten H.R.
J. Immunol.162:3687-3693(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLE
23.

"Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4."
Blanchong C.A. , Chung E.K. , Rupert K.L. , Yang Y. , Yang Z. , Zhou B. , Moulds J.M. , Yu C.Y.
Int. Immunopharmacol.1:365-392(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;DESCRIPTION OF ALLOTYPES;TISSUE SPECIFICITY
24.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-226
25.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1391
tissue: Plasma.
26.

"Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity."
Yu C.Y. , Belt K.T. , Giles C.M. , Campbell R.D. , Porter R.R.
EMBO J.5:2873-2881(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURAL BASIS OF POLYMORPHISM
27.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-862; ASN-1328 AND ASN-1391
tissue: Plasma.
28.

"Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans."
Yang Y. , Chung E.K. , Wu Y.L. , Savelli S.L. , Nagaraja H.N. , Zhou B. , Hebert M. , Jones K.N. , Shu Y. , Kitzmiller K. , Blanchong C.A. , McBride K.L. , Higgins G.C. , Rennebohm R.M. , Rice R.R. , Hackshaw K.V. , Roubey R.A. , Grossman J.M. , more...
Am. J. Hum. Genet.80:1037-1054(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SLE
29.

"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Picariello G. , Ferranti P. , Mamone G. , Roepstorff P. , Addeo F.
Proteomics8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-226 AND ASN-1328
tissue: Milk.
30.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-226; ASN-1328 AND ASN-1391
tissue: Liver.
31.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-1328
32.

"Enrichment of glycopeptides for glycan structure and attachment site identification."
Nilsson J. , Rueetschi U. , Halim A. , Hesse C. , Carlsohn E. , Brinkmalm G. , Larson G.
Nat. Methods6:809-811(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS];STRUCTURE OF CARBOHYDRATES
tissue: Cerebrospinal fluid.
33.

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A. , Ruetschi U. , Larson G. , Nilsson J.
J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-1244;IDENTIFICATION BY MASS SPECTROMETRY
34.

"X-ray crystal structure of the C4d fragment of human complement component C4."
van den Elsen J.M. , Martin A. , Wong V. , Clemenza L. , Rose D.R. , Isenman D.E.
J. Mol. Biol.322:1103-1115(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 957-1323
35.

"The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect."
Anderson M.J. , Milner C.M. , Cotton G.H. , Campbell R.D.
J. Immunol.148:2795-2802(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-1286 (ALLOTYPE C4A6)

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