C7 ELISA Kit for Human(Homo sapiens) | EIAab.comC7 ELISA Kit for Human(Homo sapiens)

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C7 (Gene name),

Complement component C7 (Protein name ), CO7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

C7;

Protein name:

Complement component C7;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer or dimer; as a C5b-7 complex it can also form multimeric rosettes. MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.

Function:

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

843

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

843:

GFSICVEVNG | KEQTMSECEA | GALRCRGQSI | SVTSIRPCAA | ETQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.78065

KEGG:

hsa:730

MIM:

217070

STRING:

9606.ENSP00000322061

String:

P10643

Pfam:

PF00057

SMR:

P10643

Uniprot:

P10643

FOR

ELISA Kit for Human Complement component C7

Cat.:

E0731h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Complement component C7

Cat.:

E0731b

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Packing:

96T

ELISA Kit for Human Complement component C7

Cat.:

E0731p

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C7

Cat.:

U0731b

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C7

Cat.:

U0731p

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Complement component C7

Cat.:

U0731h

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Packing:

96T

Polyclonal Antibody for Human Complement component C7

Cat.:

P0731Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement component C7

Monoclonal Antibody for Human Complement component C7

Protein for Human Complement component C7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤6.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤10.6%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of CO7 into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	101	99-106
Plasma	100	98-104

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CO7 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	97-107%	96-104%	96-106%	94-107%
Saliva(n=3)	96-106%	99-103%	95-108%	98-105%
heparin plasma(n=5)	94-108%	96-105%	97-105%	96-104%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"METHODS FOR PREDICTING RHEUMATOID ARTHRITIS TREATMENT RESPONSE"

Vittecoq O, Lequerre T, Cosette P, et al.

From:U.S. Patent No. 20,160,123,992.

References

1.

"The structure of human complement component C7 and the C5b-7 complex."
Discipio R.G. , Chakravari D.N. , Mueller-Eberhard H.J. , Fey G.H.
J. Biol. Chem.263:549-560(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;VARIANT PRO-587
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: PNS.
3.

"Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes."
Hobart M.J. , Fernie B.A. , DiScipio R.G.
J. Immunol.154:5188-5194(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-822;VARIANT THR-389
4.

"The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-36; TRP-503; TRP-506 AND TRP-509
5.

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-202
tissue: Plasma.
6.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-202 AND ASN-754
tissue: Plasma.
7.

"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W. , Lu Z. , Fu Y. , Wang H.P. , Wang L.H. , Chi H. , Yuan Z.F. , Zheng Z.B. , Song L.N. , Han H.H. , Liang Y.M. , Wang J.L. , Cai Y. , Zhang Y.K. , Deng Y.L. , Ying W.T. , He S.M. , Qian X.H.
Mol. Cell. Proteomics8:913-923(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-754
8.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-696;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
9.

"Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement."
Phelan M.M. , Thai C.-T. , Soares D.C. , Ogata R.T. , Barlow P.N. , Bramham J.
J. Biol. Chem.284:19637-19649(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 693-843;DISULFIDE BONDS
10.

"Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies."
Fernie B.A. , Wurzner R. , Orren A. , Morgan B.P. , Potter P.C. , Platonov A.E. , Vershinina I.V. , Shipulin G.A. , Lachmann P.J. , Hobart M.J.
J. Immunol.157:3648-3657(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C7D SER-521
11.

"Molecular bases of C7 deficiency: three different defects."
Fernie B.A. , Orren A. , Sheehan G. , Schlesinger M. , Hobart M.J.
J. Immunol.159:1019-1026(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT C7D ARG-379
12.

"Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes."
Fernie B.A. , Hobart M.J.
Hum. Genet.103:513-519(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS C7D GLN-220; GLN-682 AND HIS-687
13.

"Quantitative detection of single amino acid polymorphisms by targeted proteomics."
Su Z.D. , Sun L. , Yu D.X. , Li R.X. , Li H.X. , Yu Z.J. , Sheng Q.H. , Lin X. , Zeng R. , Wu J.R.
J. Mol. Cell Biol.3:309-315(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-389 AND PRO-587;IDENTIFICATION BY MASS SPECTROMETRY

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