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Index > Protein center > CRP(Gene name) > Human
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  • CRP (Gene name),
  • C-reactive protein (Protein name ),  CRP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (8)
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  • Gene name:
    CRP(PTX1);
    Protein name:
    C-reactive protein;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
    Function:
    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    224
    Sequence:
    50:
    MEKLLCFLVL | TSLSHAFGQT | DMSRKAFVFP | KESDTSYVSL | KAPLTKPLKA | 
    100:
    FTVCLHFYTE | LSSTRGYSIF | SYATKRQDNE | ILIFWSKDIG | YSFTVGGSEI | 
    150:
    LFEVPEVTVA | PVHICTSWES | ASGIVEFWVD | GKPRVRKSLK | KGYTVGAEAS | 
    200:
    IILGQEQDSF | GGNFEGSQSL | VGDIGNVNMW | DFVLSPDEIN | TIYLGGPFSP | 
    224:
    NVLNWRALKY | EVQGEVFTKP | QLWP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    SMR:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-reactive protein
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    ELISA Kit for Human C-reactive protein
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    ELISA Kit for Human C-reactive protein
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    E0829m
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    ELISA Kit for Human C-reactive protein
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    E0829h
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    ELISA Kit for Human C-reactive protein
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    CLIA Kit for Human C-reactive protein
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    U0829p
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    Packing:
    96T
    CLIA Kit for Human C-reactive protein
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    U0829m
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human C-reactive protein
    MSDS:
    Please sign in first.
    CLIA Kit for Human C-reactive protein
    Cat.:
    U0829r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C-reactive protein
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    U0829h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human C-reactive protein
    Cat.:
    P0829Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-reactive protein
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    P0829Rb-m
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    Polyclonal Antibody for Human C-reactive protein
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-reactive protein
    Polyclonal Antibody for Human C-reactive protein
    Monoclonal Antibody for Human C-reactive protein
    Monoclonal Antibody for Human C-reactive protein
    Monoclonal Antibody for Human C-reactive protein
    Monoclonal Antibody for Human C-reactive protein
    Monoclonal Antibody for Human C-reactive protein
    Protein for Human C-reactive protein
    Protein for Human C-reactive protein
    Cat.:
    R0829h
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Human C-reactive protein
    Protein for Human C-reactive protein
    Protein for Human C-reactive protein

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    Citations
    [2].
    Hong Jiang , Rong Wang , Yan Liu , Yun Zhang , Zhe-Yu Chen
    References
    1. 1.
      "Genomic DNA sequence for human C-reactive protein."
      Lei K.-J. , Liu T. , Zon G. , Soravia E. , Liu T.-Y. , Goldman N.D.
      J. Biol. Chem.260:13377-13383(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component."
      Woo P. , Korenberg J.R. , Whitehead A.S.
      J. Biol. Chem.260:13384-13388(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Extrahepetic transcription of human C-reactive protein."
      Murphy T.M. , Baum L. , Beaman K.
      Submitted (1990-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      Tenchini M.L. , Marchetti L. , Bossi E. , Malcovati M. , Lorenzetti R.
      Submitted (1992-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    5. 5.
      "Controlled gene expression using acute phase response elements."
      Harraghy N.
      Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Urinary bladder.
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2001-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Liver.
    11. 11.
      "Biosynthesis and postsynthetic processing of human C-reactive protein."
      Tucci A. , Goldberger G. , Whitehead A.S. , Kay R.M. , Woods D.E. , Colten H.R.
      J. Immunol.131:2416-2419(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-26
    12. 12.
      "Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1."
      Whitehead A.S. , Bruns G.A.P. , Markham A.F. , Colten H.R. , Woods D.E.
      Science221:69-71(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 144-175
    13. 13.
      "Primary structure of human C-reactive protein."
      Oliveira E.B. , Gotschlich E.C. , Liu T.-Y.
      J. Biol. Chem.254:489-502(1979) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 19-224;PYROGLUTAMATE FORMATION AT GLN-19
    14. 14.
      "Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens."
      Osmand A.P. , Gewurz H. , Friedenson B.
      Proc. Natl. Acad. Sci. U.S.A.74:1214-1218(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-55
    15. 15.
      "Selected expression profiling of full-length proteins and their variants in human plasma."
      Kiernan U.A. , Nedelkov D. , Tubbs K.A. , Niederkofler E.E. , Nelson R.W.
      Clin. Proteomics1:7-16(2004)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MASS SPECTROMETRY
    16. 16.
      "Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense."
      Zhang J. , Yang L. , Ang Z. , Yoong S.L. , Tran T.T. , Anand G.S. , Tan N.S. , Ho B. , Ding J.L.
      J. Immunol.185:6899-6910(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCN1
    17. 17.
      "Comparative analyses of pentraxins: implications for protomer assembly and ligand binding."
      Srinivasan N. , White H.E. , Emsley J. , Wood S.P. , Pepys M.B. , Blundell T.L.
      Structure2:1017-1027(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
    19. 19.
      "The physiological structure of human C-reactive protein and its complex with phosphocholine."
      Thompson D. , Pepys M.B. , Wood S.P.
      Structure7:169-177(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
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