PPBP ELISA Kit for Human(Homo sapiens) | EIAab.comPPBP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > PPBP(Gene name) > Human

PPBP (Gene name),

Platelet basic protein (Protein name ), CXCL7_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PPBP(CTAP3;CXCL7;SCYB7;TGB1;THBGB1);

Protein name:

Platelet basic protein(PBP);

Alternative:

Leukocyte-derived growth factor(LDGF);C-X-C motif chemokine 7;Small-inducible cytokine B7;Macrophage-derived growth factor(MDGF);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Beta-thromboglobulin is a homotetramer.

Function:

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

128

Sequence:

50:

100:

128:

GRKICLDPDA | PRIKKIVQKK | LAGDESAD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000296028

String:

P02775

Pfam:

PF00048

KEGG:

hsa:5473

MIM:

121010

SMR:

P02775

UniGene:

Hs.2164

Uniprot:

P02775

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ELISA Kit for Human PBP

Cat.:

E0041h

Price:

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Manual:

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Packing:

96T

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ELISA Kit for Human PBP

Cat.:

E0041p

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human PBP

Cat.:

U0041h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human PBP

Cat.:

U0041p

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human PBP

Cat.:

P0041Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human PBP

Protein for Human PBP

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of cDNA coding for connective tissue activating peptide III from a human platelet-derived lambda gt11 expression library."
Wenger R.H. , Wicki A.N. , Walz A. , Kieffer N. , Clemetson K.J.
Blood73:1498-1503(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Platelet.
2.

"Characterization of the human beta-thromboglobulin gene. Comparison with the gene for platelet factor 4."
Majumdar S. , Gonder D. , Koutsis B. , Poncz M.
J. Biol. Chem.266:5785-5789(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus."
Zhang C. , Thornton M.A. , Kowalska M.A. , Sachis B.S. , Feldman M. , Poncz M. , McKenzie S.E. , Reilly M.P.
Blood98:610-617(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Umbilical cord blood.
6.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Leukocyte.
9.

"Characterization of human platelet basic protein, a precursor form of low-affinity platelet factor 4 and beta-thromboglobulin."
Holt J.C. , Harris M.E. , Holt A.M. , Lange E. , Henschen A. , Niewiarowski S.
Biochemistry25:1988-1996(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-53
10.

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Zhang Z. , Henzel W.J.
Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-49
11.

"Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines."
Krijgsveld J. , Zaat S.A. , Meeldijk J. , van Veelen P.A. , Fang G. , Poolman B. , Brandt E. , Ehlert J.E. , Kuijpers A.J. , Engbers G.H. , Feijen J. , Dankert J.
J. Biol. Chem.275:20374-20381(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-126;IDENTIFICATION OF TC-1 AND TC-2;FUNCTION
12.

"Structural and biological characteristics of connective tissue activating peptide (CTAP-III), a major human platelet-derived growth factor."
Castor C.W. , Miller J.W. , Walz D.A.
Proc. Natl. Acad. Sci. U.S.A.80:765-769(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-66 AND 125-128
13.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 44-62
tissue: Platelet.
14.

"Complete covalent structure of human beta-thromboglobulin."
Begg G.S. , Pepper D.S. , Chesterman C.N. , Morgan F.J.
Biochemistry17:1739-1744(1978) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 48-126
15.

"Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes."
Piccardoni P. , Evangelista V. , Piccoli A. , de Gaetano G. , Walz A. , Cerletti C.
Thromb. Haemost.76:780-785(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 55-128;IDENTIFICATION OF NAP-2(73) AND NAP-2(74);FUNCTION
tissue: Platelet.
16.

"Connective tissue activation. XXXIII. Biologically active cleavage products of CTAP-III from human platelets."
Castor C.W. , Walz D.A. , Ragsdale C.G. , Hossler P.A. , Smith E.M. , Bignall M.C. , Aaron B.P. , Mountjoy K.
Biochem. Biophys. Res. Commun.163:1071-1078(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 57-68
17.

"A novel cleavage product of beta-thromboglobulin formed in cultures of stimulated mononuclear cells activates human neutrophils."
Walz A. , Baggiolini M.
Biochem. Biophys. Res. Commun.159:969-975(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-126
18.

"Limited and defined truncation at the C-terminus enhances receptor binding and degranulation activity of the neutrophil-activating peptide 2 (NAP-2). Comparison of native and recombinant NAP-2 variants."
Ehlert J.E. , Petersen F. , Kubbutat M.H. , Gerdes J. , Flad H.D. , Brandt E.
J. Biol. Chem.270:6338-6344(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-124;IDENTIFICATION OF NAP-2(1-66);FUNCTION
tissue: Peripheral blood monocyte.
19.

"Generation of the neutrophil-activating peptide NAP-2 from platelet basic protein or connective tissue-activating peptide III through monocyte proteases."
Walz A. , Baggiolini M.
J. Exp. Med.171:449-454(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-67
20.

"Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide."
Clark-Lewis I. , Mose B. , Walz A. , Baggiolini M. , Scott G.J. , Aebersold R.
Biochemistry30:3128-3135(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF 59-126
21.

"Novel C-terminally truncated isoforms of the CXC chemokine beta-thromboglobulin and their impact on neutrophil functions."
Ehlert J.E. , Gerdes J. , Flad H.-D. , Brandt E.
J. Immunol.161:4975-4982(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF CTAP-III(1-81) AND NAP-2(1-63);FUNCTION;PROTEOLYTIC PROCESSING OF C-TERMINAL
22.

"Purification, crystallization and preliminary X-ray diffraction analysis of recombinant human neutrophil-activating peptide 2 (rhNAP-2)."
Kungl A.J. , Machius M. , Huber R. , Schwer C. , Lam C. , Aschauer H. , Ehn G. , Lindley I.J.D. , Auer M.
FEBS Lett.347:300-303(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 59-128
23.

"The crystal structure of recombinant human neutrophil-activating peptide-2 (M6L) at 1.9-A resolution."
Malkowski M.G. , Wu J.Y. , Lazar J.B. , Johnson P.H. , Edwards B.F.P.
J. Biol. Chem.270:7077-7087(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 59-128

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