Protein name:
Dipeptidyl peptidase 4 ;
Alternative:
T-cell activation antigen CD26 ;Dipeptidyl peptidase IV (DPP IV) ;Thymocyte-activating molecule (THAM) ;
CD:
CD26 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer. Heterodimer with Seprase (FAP). Requires homodimerization for optimal dipeptidyl peptidase activity and T-cell costimulation. Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Associates with collagen. Interacts with PTPRC; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes. Interacts (extracellular domain) with ADA; does not inhibit its dipeptidyl peptidase activity. Interacts with CAV1 (via the N-terminus); the interaction is direct. Interacts (via cytoplasmic tail) with CARD11 (via PDZ domain); its homodimerization is necessary for interaction with CARD11. Interacts with IGF2R; the interaction is direct. Interacts with GPC3 (By similarity). Homodimer.
Function:
Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.
Subcellular Location:
Cell membrane
Single-pass type II membrane protein
Apical cell membrane
Single-pass type II membrane protein
Cell projection
invadopodium membrane
Single-pass type II membrane protein
Cell projection
lamellipodium membrane
Single-pass type II membrane protein
Cell junction
Membrane raft
Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids. Redistributed to membrane rafts in T-cell in a interleukin-12-dependent activation. Its interaction with CAV1 is necessary for its translocation to membrane rafts. Colocalized with PTPRC in membrane rafts. Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma. Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion. Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface.
Protein Attributes:
50:
MKTPWKVLLG | LLGVAALVTI | ITVPIVLLSK | DEAAADSRRT | YSLADYLKST |
100:
FRVKSYSLWW | VSDFEYLYKQ | ENNILLLNAE | HGNSSIFLEN | STFESFGYHS |
150:
VSPDRLFVLL | EYNYVKQWRH | SYTASYNIYD | VNKRQLITEE | KIPNNTQWIT |
200:
WSPEGHKLAY | VWKNDIYVKV | EPHLPSHRIT | STGEENVIYN | GITDWVYEEE |
250:
VFGAYSALWW | SPNNTFLAYA | QFNDTGVPLI | EYSFYSDESL | QYPKTVWIPY |
300:
PKAGAVNPTV | KFFIVNIDSL | SSSSSAAPIQ | IPAPASVARG | DHYLCDVVWA |
350:
TEERISLQWL | RRIQNYSVMA | ICDYDKINLT | WNCPSEQQHV | EMSTTGWVGR |
400:
FRPAEPHFTS | DGSSFYKIIS | DKDGYKHICH | FPKDKKDCTF | ITKGAWEVIS |
450:
IEALTSDYLY | YISNQYKEMP | GGRNLYKIQL | TDHTNVKCLS | CDLNPERCQY |
500:
YAVSFSKEAK | YYQLGCWGPG | LPLYTLHRST | DHKELRVLED | NSALDRMLQD |
550:
VQMPSKKLDF | IVLNETRFWY | QMILPPHFDK | SKKYPLLLDV | YAGPCSQKAD |
600:
ASFRLNWATY | LASTENIIVA | SFDGRGSGYQ | GDKIMHAINR | RLGTLEVEDQ |
650:
IEAARQFVKM | GFVDSKRVAI | WGWSYGGYVT | SMVLGSGSGV | FKCGIAVAPV |
700:
SRWEYYDSVY | TERYMGLPIP | EDNLDHYRNS | TVMSRAEHFK | QVEYLLIHGT |
750:
ADDNVHFQQS | AQISKALVDA | GVDFQAMWYT | DEDHGIASST | AHQHIYSHMS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
ELISA Kit for Mouse Dipeptidyl peptidase 4
ELISA Kit for Mouse Dipeptidyl peptidase 4
ELISA Kit for Mouse Dipeptidyl peptidase 4
ELISA Kit for Mouse Dipeptidyl peptidase 4
ELISA Kit for Mouse Dipeptidyl peptidase 4
CLIA Kit for Mouse Dipeptidyl peptidase 4
CLIA Kit for Mouse Dipeptidyl peptidase 4
CLIA Kit for Mouse Dipeptidyl peptidase 4
CLIA Kit for Mouse Dipeptidyl peptidase 4
CLIA Kit for Mouse Dipeptidyl peptidase 4
Polyclonal Antibody for Mouse Dipeptidyl peptidase 4
Polyclonal Antibody for Mouse Dipeptidyl peptidase 4
Polyclonal Antibody for Mouse Dipeptidyl peptidase 4
Polyclonal Antibody for Mouse Dipeptidyl peptidase 4
Polyclonal Antibody for Mouse Dipeptidyl peptidase 4
Monoclonal Antibody for Mouse Dipeptidyl peptidase 4
Monoclonal Antibody for Mouse Dipeptidyl peptidase 4
Monoclonal Antibody for Mouse Dipeptidyl peptidase 4
Monoclonal Antibody for Mouse Dipeptidyl peptidase 4
Monoclonal Antibody for Mouse Dipeptidyl peptidase 4
Protein for Mouse Dipeptidyl peptidase 4
Protein for Mouse Dipeptidyl peptidase 4
Protein for Mouse Dipeptidyl peptidase 4
Protein for Mouse Dipeptidyl peptidase 4
Protein for Mouse Dipeptidyl peptidase 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Swiss .
tissue :
Thymus .
2.
Marguet D.A.
Submitted (1994-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
B10.A .
tissue :
Liver .
4.
"The transcriptional landscape of the mammalian genome."
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
strain :
NOD .
tissue :
Kidney .
tissue :
Thymus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 1-20
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-145 AND ASN-514