Protein name:
Erythropoietin receptor (EPO-R) ;
Alternative:
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-455 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L and INPP5D/SHIP1.
Function:
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MYHFGATLWP | GVGSLCLLLA | GATWAPSPNS | PDAKFESKAA | LLAARGPEEL |
100:
LCFTERLEDL | VCFWEEAGSA | GVGPEDYSFS | YQLEGEPWKP | CHLHQGPTAR |
150:
GSVRFWCSLP | TADTSSFVPL | ELRVTEVSSG | APRYHRIIHI | NEVVLLDPPA |
200:
GLLARRAEES | GHVVLRWLPP | PGAPMASLIR | YEVNISTENA | AGGVQRVEIL |
250:
DGRTECVLSN | LRGGTRYTFM | VRARMAEPSF | GGFWSAWSEP | ASLLTASDLD |
300:
PLILTLSLIL | VLILLLLAVL | ALLSHRRTLK | QKIWPGIPSP | EGEFEGLFTT |
350:
HKGNFQLWLY | QTDGCLWWSP | CTPFAEDPPA | PLEVLSERCW | GVTQAVEPAA |
400:
DDEGSLLEPV | GSEHARDTYL | VLDKWLLPRR | PASEDLPQPG | GDLDMAAMDE |
450:
ASEASFCSSA | LALKPGPEGA | SAASFEYTIL | DPSSQLLRPR | ALPAELPPTP |
500:
PHLKYLYLVV | SDSGISTDYS | SGGSQETQGG | SSSGPYSNPY | ENSLVPAPEP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Dog
Polyclonal Antibody for Pig EPO-R
Polyclonal Antibody for Pig EPO-R
Polyclonal Antibody for Pig EPO-R
Polyclonal Antibody for Pig EPO-R
Polyclonal Antibody for Pig EPO-R
Monoclonal Antibody for Pig EPO-R
Monoclonal Antibody for Pig EPO-R
Monoclonal Antibody for Pig EPO-R
Monoclonal Antibody for Pig EPO-R
Monoclonal Antibody for Pig EPO-R
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
tissue :
Liver .