ERCC5 ELISA Kit for Human(Homo sapiens) | EIAab.comERCC5 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ERCC5(Gene name) > Human

ERCC5 (Gene name),

DNA repair protein complementing XP-G cells (Protein name ), ERCC5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ERCC5(ERCM2;XPG;XPGC);

Protein name:

DNA repair protein complementing XP-G cells;

Alternative:

Xeroderma pigmentosum group G-complementing protein;DNA excision repair protein ERCC-5;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with PCNA.

Function:

Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

1186

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1186:

SDDDGGKEKM | VLVTARSVFG | KKRRKLRRAR | GRKRKT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.258429

Pfam:

PF00867

KEGG:

hsa:2073

STRING:

9606.ENSP00000347978

MIM:

133530

String:

P28715

SMR:

P28715

Uniprot:

P28715

FOR

ELISA Kit for Human DNA repair protein complementing XP-G cells

Cat.:

E1095m

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MSDS:

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Packing:

96T

ELISA Kit for Human DNA repair protein complementing XP-G cells

Cat.:

E1095h

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MSDS:

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Packing:

96T

CLIA Kit for Human DNA repair protein complementing XP-G cells

Cat.:

U1095m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human DNA repair protein complementing XP-G cells

Cat.:

U1095h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human DNA repair protein complementing XP-G cells

Cat.:

P1095Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human DNA repair protein complementing XP-G cells

Cat.:

P1095Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human DNA repair protein complementing XP-G cells

Protein for Human DNA repair protein complementing XP-G cells

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Complementation of the DNA repair defect in Xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2."
Scherly D. , Nouspikel T. , Corlet J. , Ucla C. , Bairoch A. , Clarkson S.G.
Nature363:182-185(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-1053; ARG-1080 AND HIS-1104
2.

"An ERCC5 gene with homology to yeast RAD2 is involved in group G Xeroderma pigmentosum."
Shiomi T. , Harada Y.-N. , Saito T. , Shiomi N. , Okuno Y. , Yamaizumi M.
Mutat. Res.314:167-175(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-254; ARG-1053 AND ARG-1080
3.

"Human ERCC5 cDNA-cosmid complementation for excision repair and bipartite amino acid domains conserved with RAD proteins of Saccharomyces cerevisiae and Schizosaccharomyces pombe."
Macinnes M.A. , Dickson J.A. , Hernandez R.R. , Learmonth D. , Lin G.Y. , Mudgett J.S. , Park M.S. , Schauer S. , Reynolds R.J. , Strniste G.F. , Yu J.Y.
Mol. Cell. Biol.13:6393-6402(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-254; ARG-1053 AND ARG-1080
4.

"The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms."
Emmert S. , Schneider T.D. , Khan S.G. , Kraemer K.H.
Nucleic Acids Res.29:1443-1452(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1 AND 3)
5.

Zan Q. , Guo J.H. , Yu L.
Submitted (2001-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS VAL-254; ARG-1053 AND ARG-1080
tissue: Bone marrow.
6.

NIEHS SNPs program
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ARG-181; VAL-254; ARG-256; CYS-311; LYS-399; SER-529; ILE-590; LEU-597; SER-879; HIS-1009 AND ARG-1053; ARG-1080 AND GLN-1080
7.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS ARG-1053 AND ARG-1080
tissue: Eye.
9.

"The human gene for Xeroderma pigmentosum complementation group G (XPG) maps to 13q33 by fluorescence in situ hybridization."
Samec S. , Jones T.A. , Corlet J. , Scherly D. , Sheer D. , Wood R.D. , Clarkson S.G.
Genomics21:283-285(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-88
10.

"Isolation of active recombinant XPG protein, a human DNA repair endonuclease."
O'Donovan A. , Scherly D. , Clarkson S.G. , Wood R.D.
J. Biol. Chem.269:15965-15968(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
11.

"XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair."
O'Donovan A. , Davies A.A. , Moggs J.G. , West S.C. , Wood R.D.
Nature371:432-435(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
12.

"Human Xeroderma pigmentosum group G gene encodes a DNA endonuclease."
Habraken Y. , Sung P. , Prakash L. , Prakash S.
Nucleic Acids Res.22:3312-3316(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
13.

"XPG protein has a structure-specific endonuclease activity."
Cloud K.G. , Shen B. , Strniste G.F. , Park M.S.
Mutat. Res.347:55-60(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION;SUBCELLULAR LOCATION
14.

"The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21."
Gary R. , Ludwig D.L. , Cornelius H.L. , MacInnes M.A. , Park M.S.
J. Biol. Chem.272:24522-24529(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PCNA
15.

"The XPG story."
Clarkson S.G.
Biochimie85:1113-1121(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
16.

"A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy."
Cleaver J.E. , Thompson L.H. , Richardson A.S. , States J.C.
Hum. Mutat.14:9-22(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS XP-G
17.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-8;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Mutations that disable the DNA repair gene XPG in a Xeroderma pigmentosum group G patient."
Nouspikel T. , Clarkson S.G.
Hum. Mol. Genet.3:963-967(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-G VAL-792
20.

"A common mutational pattern in Cockayne syndrome patients from Xeroderma pigmentosum group G: implications for a second XPG function."
Nouspikel T. , Lalle P. , Leadon S.A. , Cooper P.K. , Clarkson S.G.
Proc. Natl. Acad. Sci. U.S.A.94:3116-3121(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-G VAL-792
21.

"Xeroderma pigmentosum group G with severe neurological involvement and features of Cockayne syndrome in infancy."
Zafeiriou D.I. , Thorel F. , Andreou A. , Kleijer W.J. , Raams A. , Garritsen V.H. , Gombakis N. , Jaspers N.G.J. , Clarkson S.G.
Pediatr. Res.49:407-412(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-G HIS-72
22.

"The founding members of xeroderma pigmentosum group G produce XPG protein with severely impaired endonuclease activity."
Lalle P. , Nouspikel T. , Constantinou A. , Thorel F. , Clarkson S.G.
J. Invest. Dermatol.118:344-351(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-G PRO-858
23.

"Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients."
Emmert S. , Slor H. , Busch D.B. , Batko S. , Albert R.B. , Coleman D. , Khan S.G. , Abu-Libdeh B. , DiGiovanna J.J. , Cunningham B.B. , Lee M.M. , Crollick J. , Inui H. , Ueda T. , Hedayati M. , Grossman L. , Shahlavi T. , Cleaver J.E. , more...
J. Invest. Dermatol.118:972-982(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT XP-G THR-874

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