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Index > Protein center > ESRRG(Gene name) > Human
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  • ESRRG (Gene name),
  • Estrogen-related receptor gamma (Protein name ),  ERR3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ESRRG(ERR3;ERRG2;KIAA0832;NR3B3);
    Protein name:
    Estrogen-related receptor gamma;
    Alternative:
    Estrogen receptor-related protein 3;ERR gamma-2;Nuclear receptor subfamily 3 group B member 3;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Binds TLE1, PNRC1 and PNRC2. Binds GRIP1 (By similarity). Interacts with NRIP1, NCOA1 and NCOR2.
    Function:
    Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    458
    Sequence:
    50:
    MDSVELCLPE | SFSLHYEEEL | LCRMSNKDRH | IDSSCSSFIK | TEPSSPASLT | 
    100:
    DSVNHHSPGG | SSDASGSYSS | TMNGHQNGLD | SPPLYPSAPI | LGGSGPVRKL | 
    150:
    YDDCSSTIVE | DPQTKCEYML | NSMPKRLCLV | CGDIASGYHY | GVASCEACKA | 
    200:
    FFKRTIQGNI | EYSCPATNEC | EITKRRRKSC | QACRFMKCLK | VGMLKEGVRL | 
    250:
    DRVRGGRQKY | KRRIDAENSP | YLNPQLVQPA | KKPYNKIVSH | LLVAEPEKIY | 
    300:
    AMPDPTVPDS | DIKALTTLCD | LADRELVVII | GWAKHIPGFS | TLSLADQMSL | 
    350:
    LQSAWMEILI | LGVVYRSLSF | EDELVYADDY | IMDEDQSKLA | GLLDLNNAIL | 
    400:
    QLVKKYKSMK | LEKEEFVTLK | AIALANSDSM | HIEDVEAVQK | LQDVLHEALQ | 
    450:
    DYEAGQHMED | PRRAGKMLMT | LPLLRQTSTK | AVQHFYNIKL | EGKVPMHKLF | 
    458:
    LEMLEAKV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    Pfam:
    MIM:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Estrogen-related receptor gamma
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    E0289r
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    ELISA Kit for Human Estrogen-related receptor gamma
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    E0289h
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    ELISA Kit for Human Estrogen-related receptor gamma
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    E0289m
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    CLIA Kit for Human Estrogen-related receptor gamma
    Cat.:
    U0289m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Estrogen-related receptor gamma
    Cat.:
    U0289h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Estrogen-related receptor gamma
    Cat.:
    U0289r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Estrogen-related receptor gamma
    Cat.:
    P0289Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Estrogen-related receptor gamma
    Cat.:
    P0289Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Estrogen-related receptor gamma
    Cat.:
    P0289Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Estrogen-related receptor gamma
    Monoclonal Antibody for Human Estrogen-related receptor gamma
    Monoclonal Antibody for Human Estrogen-related receptor gamma
    Protein for Human Estrogen-related receptor gamma
    Protein for Human Estrogen-related receptor gamma
    Protein for Human Estrogen-related receptor gamma

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR."
      Chen F. , Zhang Q. , McDonald T. , Davidoff M.J. , Bailey W. , Bai C. , Liu Q. , Caskey C.T.
      Gene228:101-109(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Hirosawa M. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      "Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type IIa at 1q41."
      Eudy J.D. , Yao S.F. , Weston M.D. , Ma-Edmonds M. , Talmadge C.B. , Cheng J.J. , Kimberling W.J. , Sumegi J.
      Genomics50:382-384(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
    4. 4.
      "Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult."
      Heard D.J. , Norby P.L. , Holloway J. , Vissing H.
      Mol. Endocrinol.14:382-392(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Kidney.
      tissue: Retina.
      tissue: Skeletal muscle.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 4)
      tissue: Brain.
      tissue: Placenta.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Fetal kidney.
    7. 7.
      NIEHS SNPs program
      Submitted (2004-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-50
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Eye.
      tissue: Placenta.
    11. 11.
      "Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3."
      Hong H. , Yang L. , Stallcup M.R.
      J. Biol. Chem.274:22618-22626(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-129 (ISOFORM 1)
      tissue: Brain.
    12. 12.
      "Identification of PNRC2 and TLE1 as activation function-1 cofactors of the orphan nuclear receptor ERRgamma."
      Hentschke M. , Borgmeyer U.
      Biochem. Biophys. Res. Commun.312:975-982(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TLE1 AND PNRC2;TISSUE SPECIFICITY
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-40;MUTAGENESIS OF LYS-40
    14. 14.
      "Transcriptional ERRgamma2-mediated activation is regulated by sentrin-specific proteases."
      Hentschke M. , Suesens U. , Borgmeyer U.
      Biochem. J.419:167-176(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-40;PHOSPHORYLATION AT SER-45;FUNCTION;MUTAGENESIS OF PHE-38; ILE-39; LYS-40; THR-41; GLU-42; SER-44 AND SER-45
    15. 15.
      "Phosphorylation-dependent sumoylation regulates estrogen-related receptor-alpha and -gamma transcriptional activity through a synergy control motif."
      Tremblay A.M. , Wilson B.J. , Yang X.-J. , Giguere V.
      Mol. Endocrinol.22:570-584(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-40;PHOSPHORYLATION AT SER-45;FUNCTION;MUTAGENESIS OF LYS-40 AND SER-45
    16. 16.
      "An acetylation switch modulates the transcriptional activity of estrogen-related receptor alpha."
      Wilson B.J. , Tremblay A.M. , Deblois G. , Sylvain-Drolet G. , Giguere V.
      Mol. Endocrinol.24:1349-1358(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION BY PCAF/KAT2B
    17. 17.
      "Peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells."
      Cho Y. , Hazen B.C. , Russell A.P. , Kralli A.
      J. Biol. Chem.288:25207-25218(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3."
      Greschik H. , Wurtz J.-M. , Sanglier S. , Bourguet W. , van Dorsselaer A. , Moras D. , Renaud J.-P.
      Mol. Cell9:303-313(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 229-458 IN COMPLEXES WITH INVERSE AGONISTS AND NCOA1;FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY
    19. 19.
      "Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma."
      Chao E.Y.H. , Collins J.L. , Gaillard S. , Miller A.B. , Wang L. , Orband-Miller L.A. , Nolte R.T. , McDonnell D.P. , Willson T.M. , Zuercher W.J.
      Bioorg. Med. Chem. Lett.16:821-824(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 233-458 IN COMPLEX WITH INVERSE AGONIST
    20. 20.
      "X-ray crystal structures of the estrogen-related receptor-gamma ligand binding domain in three functional states reveal the molecular basis of small molecule regulation."
      Wang L. , Zuercher W.J. , Consler T.G. , Lambert M.H. , Miller A.B. , Orband-Miller L.A. , McKee D.D. , Willson T.M. , Nolte R.T.
      J. Biol. Chem.281:37773-37781(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 229-458 IN COMPLEXES WITH AGONIST AND INVERSE AGONIST; NRIP1 AND NCOR2;SUBUNIT
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