Protein name:
Junctophilin-1 (JP-1) ;
Alternative:
Junctophilin type 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Endoplasmic reticulum membrane
Single-pass type IV membrane protein
Sarcoplasmic reticulum membrane
Single-pass type IV membrane protein
Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands.
Protein Attributes:
50:
MTGGRFDFDD | GGTYCGGWEE | GKAHGHGICT | GPKGQGEYSG | SWSHGFEVVG |
100:
GYTWPSGNTY | QGYWAQGKRH | GLGVETKGKW | MYRGEWSHGF | KGRYGVRQSL |
150:
CTPARYEGTW | SNGLQDGYGV | ETYGDGGTYQ | GQWAGGMRHG | YGVRQSVPYG |
200:
MATVIRSPLR | TSLASLRSEQ | SNGSVLHDAA | AAADSPAGTR | GGFVLNFHAD |
250:
AELAGKKKGG | LFRRGSLLGS | MKLRKSESKS | SISSKRSSVR | SDAAMSRISS |
300:
SDANSTISFG | DVDCDFCPVE | DHVDATTTET | YMGEWKNDKR | NGFGVSERSN |
350:
GMKYEGEWAN | NKRHGYGCTV | FPDGSKEEGK | YKNNILVRGI | RKQLIPIRHT |
400:
KTREKVDRAI | EGAQRAAAMA | RTKVEIANSR | TAHARAKADA | ADQAALAARQ |
450:
ECDIARAVAR | ELSPDFYQPG | PDYVKQRFQE | GVDAKENPEE | KVPEKPPTPK |
500:
ESPHFYRKGT | TPPRSPEASP | KHSHSPASSP | KPLKKQNPSS | GARLNQDKRS |
550:
VADEQVTAIV | NKPLMSKAPT | KEAGAVVPQS | KYSGRHHIPN | PSNGELHSQY |
600:
HGYYVKLNAP | QHPPVDVEDG | DGSSQSSSAL | VHKPSANKWS | PSKSVTKPVA |
650:
KESKAEPKAK | KSELAIPKNP | ASNDSCPALE | KEANSGPNSI | MIVLVMLLNI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Mouse
Polyclonal Antibody for Human JP-1
Polyclonal Antibody for Human JP-1
Polyclonal Antibody for Human JP-1
Monoclonal Antibody for Human JP-1
Monoclonal Antibody for Human JP-1
Monoclonal Antibody for Human JP-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
2.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 421-661;TISSUE SPECIFICITY
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-448 AND SER-452;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157; THR-448; SER-452; THR-461; SER-465 AND SER-469;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-220 AND SER-475;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]