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Index > Protein center > MAP4K1(Gene name) > Human
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  • MAP4K1 (Gene name),
  • Mitogen-activated protein kinase kinase kinase kinase 1 (Protein name ),  M4K1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    MAP4K1(HPK1);
    Protein name:
    Mitogen-activated protein kinase kinase kinase kinase 1;
    Alternative:
    MAPK/ERK kinase kinase kinase 1(MEK kinase kinase 1;MEKKK 1);Hematopoietic progenitor kinase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with MAP3K1.
    Function:
    May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    833
    Sequence:
    50:
    MDVVDPDIFN | RDPRDHYDLL | QRLGGGTYGE | VFKARDKVSG | DLVALKMVKM | 
    100:
    EPDDDVSTLQ | KEILILKTCR | HANIVAYHGS | YLWLQKLWIC | MEFCGAGSLQ | 
    150:
    DIYQVTGSLS | ELQISYVCRE | VLQGLAYLHS | QKKIHRDIKG | ANILINDAGE | 
    200:
    VRLADFGISA | QIGATLARRL | SFIGTPYWMA | PEVAAVALKG | GYNELCDIWS | 
    250:
    LGITAIELAE | LQPPLFDVHP | LRVLFLMTKS | GYQPPRLKEK | GKWSAAFHNF | 
    300:
    IKVTLTKSPK | KRPSATKMLS | HQLVSQPGLN | RGLILDLLDK | LKNPGKGPSI | 
    350:
    GDIEDEEPEL | PPAIPRRIRS | THRSSSLGIP | DADCCRRHME | FRKLRGMETR | 
    400:
    PPANTARLQP | PRDLRSSSPR | KQLSESSDDD | YDDVDIPTPA | EDTPPPLPPK | 
    450:
    PKFRSPSDEG | PGSMGDDGQL | SPGVLVRCAS | GPPPNSPRPG | PPPSTSSPHL | 
    500:
    TAHSEPSLWN | PPSRELDKPP | LLPPKKEKMK | RKGCALLVKL | FNGCPLRIHS | 
    550:
    TAAWTHPSTK | DQHLLLGAEE | GIFILNRNDQ | EATLEMLFPS | RTTWVYSINN | 
    600:
    VLMSLSGKTP | HLYSHSILGL | LERKETRAGN | PIAHISPHRL | LARKNMVSTK | 
    650:
    IQDTKGCRAC | CVAEGASSGG | PFLCGALETS | VVLLQWYQPM | NKFLLVRQVL | 
    700:
    FPLPTPLSVF | ALLTGPGSEL | PAVCIGVSPG | RPGKSVLFHT | VRFGALSCWL | 
    750:
    GEMSTEHRGP | VQVTQVEEDM | VMVLMDGSVK | LVTPEGSPVR | GLRTPEIPMT | 
    800:
    EAVEAVAMVG | GQLQAFWKHG | VQVWALGSDQ | LLQELRDPTL | TFRLLGSPRL | 
    833:
    ECSGTISPHC | NLLLPGSSNS | PASASRVAGI | TGL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    E10336h
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    96T
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    ELISA Kit for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    E10336m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    U10336m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    U10336h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    P10336Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Cat.:
    P10336Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Monoclonal Antibody for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Protein for Human Mitogen-activated protein kinase kinase kinase kinase 1
    Protein for Human Mitogen-activated protein kinase kinase kinase kinase 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade."
      Hu M.C.-T. , Qiu W.R. , Wang X. , Meyer C.F. , Tan T.-H.
      Genes Dev.10:2251-2264(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH MAP3K1
      tissue: Fetal liver.
    2. 2.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-421 AND SER-586;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    4. 4.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-405; SER-407; SER-413 AND SER-421;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 7.
      "The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1."
      Wang H. , Chen Y. , Lin P. , Li L. , Zhou G. , Liu G. , Logsdon C. , Jin J. , Abbruzzese J.L. , Tan T.H. , Wang H.
      J. Biol. Chem.289:4009-4017(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION AT THR-165; SER-171; THR-175 AND THR-355;UBIQUITINATION;MUTAGENESIS OF THR-355;INTERACTION WITH FBXW8
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