MED17 ELISA Kit for Human(Homo sapiens) | EIAab.comMED17 ELISA Kit for Human(Homo sapiens) | EIAab.com

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MED17 (Gene name),

Mediator of RNA polymerase II transcription subunit 17 (Protein name ), MED17_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

MED17(ARC77;CRSP6;DRIP77;DRIP80;TRAP80);

Protein name:

Mediator of RNA polymerase II transcription subunit 17;

Alternative:

Cofactor required for Sp1 transcriptional activation subunit 6(CRSP complex subunit 6);Activator-recruited cofactor 77 kDa component(ARC77);Thyroid hormone receptor-associated protein complex 80 kDa component(Trap80);Mediator complex subunit 17;Vitamin D3 receptor-interacting protein complex 80 kDa component(DRIP80);Transcriptional coactivator CRSP77;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with GATA1 and PPARG (By similarity). Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with STAT2.

Function:

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

651

Sequence:

50:

MSGVRAVRIS | IESACEKQVH | EVGLDGTETY | LPPLSMSQNL | ARLAQRIDFS |

100:

QGSGSEEEEA | AGTEGDAQEW | PGAGSSADQD | DEEGVVKFQP | SLWPWDSVRN |

150:

NLRSALTEMC | VLYDVLSIVR | DKKFMTLDPV | SQDALPPKQN | PQTLQLISKK |

200:

KSLAGAAQIL | LKGAERLTKS | VTENQENKLQ | RDFNSELLRL | RQHWKLRKVG |

250:

DKILGDLSYR | SAGSLFPHHG | TFEVIKNTDL | DLDKKIPEDY | CPLDVQIPSD |

300:

LEGSAYIKVS | IQKQAPDIGD | LGTVNLFKRP | LPKSKPGSPH | WQTKLEAAQN |

350:

VLLCKEIFAQ | LSREAVQIKS | QVPHIVVKNQ | IISQPFPSLQ | LSISLCHSSN |

400:

DKKSQKFATE | KQCPEDHLYV | LEHNLHLLIR | EFHKQTLSSI | MMPHPASAPF |

450:

GHKRMRLSGP | QAFDKNEINS | LQSSEGLLEK | IIKQAKHIFL | RSRAAATIDS |

500:

LASRIEDPQI | QAHWSNINDV | YESSVKVLIT | SQGYEQICKS | IQLQLNIGVE |

550:

QIRVVHRDGR | VITLSYQEQE | LQDFLLSQMS | QHQVHAVQQL | AKVMGWQVLS |

600:

FSNHVGLGPI | ESIGNASAIT | VASPSGDYAI | SVRNGPESGS | KIMVQFPRNQ |

650:

CKDLPKSDVL | QDNKWSHLRG | PFKEVQWNKM | EGRNFVYKME | LLMSALSPCL |

651:

L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

String:

KEGG:

STRING:

9606.ENSP00000251871

MIM:

Pfam:

Uniprot:

FOR

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17

ELISA Kit for Human Mediator of RNA polymerase II transcription subunit 17

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17

CLIA Kit for Human Mediator of RNA polymerase II transcription subunit 17

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Polyclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Monoclonal Antibody for Human Mediator of RNA polymerase II transcription subunit 17

Protein for Human Mediator of RNA polymerase II transcription subunit 17

Protein for Human Mediator of RNA polymerase II transcription subunit 17

Protein for Human Mediator of RNA polymerase II transcription subunit 17

Protein for Human Mediator of RNA polymerase II transcription subunit 17

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators."
Ito M. , Yuan C.-X. , Malik S. , Gu W. , Fondell J.D. , Yamamura S. , Fu Z.-Y. , Zhang X. , Qin J. , Roeder R.G.
Mol. Cell3:361-370(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 306-319; 405-415 AND 592-602;TISSUE SPECIFICITY;IDENTIFICATION IN TRAP COMPLEX;VARIANT ASP-69
tissue: Cervix carcinoma.
2.

"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex."
Rachez C. , Lemon B.D. , Suldan Z. , Bromleigh V. , Gamble M. , Naeaer A.M. , Erdjument-Bromage H. , Tempst P. , Freedman L.P.
Nature398:824-828(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 88-99 AND 607-619;IDENTIFICATION IN ARC COMPLEX;VARIANT ASP-69
tissue: Cervix carcinoma.
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ASP-69
tissue: Embryo.
4.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-69
tissue: Skin.
6.

"The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1."
Ryu S. , Zhou S. , Ladurner A.G. , Tjian R.
Nature397:446-450(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 269-651 (ISOFORM 1)
7.

"Composite co-activator ARC mediates chromatin-directed transcriptional activation."
Naeaer A.M. , Beaurang P.A. , Zhou S. , Abraham S. , Solomon W.B. , Tjian R.
Nature398:828-832(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN ARC COMPLEX;PROTEIN SEQUENCE OF 168-179 AND 355-361
8.

"Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3."
Sato S. , Tomomori-Sato C. , Banks C.A.S. , Sorokina I. , Parmely T.J. , Kong S.E. , Jin J. , Cai Y. , Lane W.S. , Brower C.S. , Conaway R.C. , Conaway J.W.
J. Biol. Chem.278:15123-15127(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED10
9.

"Role of metazoan mediator proteins in interferon-responsive transcription."
Lau J.F. , Nusinzon I. , Burakov D. , Freedman L.P. , Horvath C.M.
Mol. Cell. Biol.23:620-628(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STAT2
10.

"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology."
Sato S. , Tomomori-Sato C. , Parmely T.J. , Florens L. , Zybailov B. , Swanson S.K. , Banks C.A.S. , Jin J. , Cai Y. , Washburn M.P. , Conaway J.W. , Conaway R.C.
Mol. Cell14:685-691(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX
11.

"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription."
Zhang X. , Krutchinsky A. , Fukuda A. , Chen W. , Yamamura S. , Chait B.T. , Roeder R.G.
Mol. Cell19:89-100(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MED1; MED10; MED18; MED21; MED28 AND MED30;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE MEDIATOR COMPLEX;ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II
12.

"Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly."
Baek H.J. , Kang Y.K. , Roeder R.G.
J. Biol. Chem.281:15172-15181(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MED1 AND MED10
13.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
14.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-69;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ASP-69;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex."
Kaufmann R. , Straussberg R. , Mandel H. , Fattal-Valevski A. , Ben-Zeev B. , Naamati A. , Shaag A. , Zenvirt S. , Konen O. , Mimouni-Bloch A. , Dobyns W.B. , Edvardson S. , Pines O. , Elpeleg O.
Am. J. Hum. Genet.87:667-670(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MCPHSBA PRO-371

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