Gene name:
MRGPRX1 (MRGX1;SNSR3;SNSR4) ;
Protein name:
Mas-related G-protein coupled receptor member X1 ;
Alternative:
Sensory neuron-specific G-protein coupled receptor 3/4 ;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in an histamine-independent manner.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MDPTISTLDT | ELTPINGTEE | TLCYKQTLSL | TVLTCIVSLV | GLTGNAVVLW |
100:
LLGCRMRRNA | FSIYILNLAA | ADFLFLSGRL | IYSLLSFISI | PHTISKILYP |
150:
VMMFSYFAGL | SFLSAVSTER | CLSVLWPIWY | RCHRPTHLSA | VVCVLLWALS |
200:
LLRSILEWML | CGFLFSGADS | AWCQTSDFIT | VAWLIFLCVV | LCGSSLVLLI |
250:
RILCGSRKIP | LTRLYVTILL | TVLVFLLCGL | PFGIQFFLFL | WIHVDREVLF |
300:
CHVHLVSIFL | SALNSSANPI | IYFFVGSFRQ | RQNRQNLKLV | LQRALQDASE |
322:
VDEGGGQLPE | EILELSGSRL | EQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Mas-related G-protein coupled receptor member X1
ELISA Kit for Human Mas-related G-protein coupled receptor member X1
ELISA Kit for Human Mas-related G-protein coupled receptor member X1
CLIA Kit for Human Mas-related G-protein coupled receptor member X1
CLIA Kit for Human Mas-related G-protein coupled receptor member X1
CLIA Kit for Human Mas-related G-protein coupled receptor member X1
Polyclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Polyclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Polyclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Monoclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Monoclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Monoclonal Antibody for Human Mas-related G-protein coupled receptor member X1
Protein for Human Mas-related G-protein coupled receptor member X1
Protein for Human Mas-related G-protein coupled receptor member X1
Protein for Human Mas-related G-protein coupled receptor member X1
R&D Technical Data
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Precision
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Recovery
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Linearity
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