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Index > Protein center > MYO18A(Gene name) > Human
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  • MYO18A (Gene name),
  • Myosin-XVIIIa (Protein name ),  MY18A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MYO18A(KIAA0216;MYSPDZ);
    Protein name:
    Myosin-XVIIIa;
    Alternative:
    Myosin containing a PDZ domain;Molecule associated with JAK3 N-terminus(MAJN);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Interacts with JAK3 and actin.
    Function:
    May be involved in the maintenance of the stromal cell architectures required for cell to cell contact.
    Subcellular Location:
    Isoform 2 Cytoplasm Lacks the PDZ domain. Diffusely localized in the cytoplasm.
    Protein Attributes:
    Sequence length:
    2054
    Sequence:
    50:
    MFNLMKKDKD | KDGGRKEKKE | KKEKKERMSA | AELRSLEEMS | LRRGFFNLNR | 
    100:
    SSKRESKTRL | EISNPIPIKV | ASGSDLHLTD | IDSDSNRGSV | ILDSGHLSTA | 
    150:
    SSSDDLKGEE | GSFRGSVLQR | AAKFGSLAKQ | NSQMIVKRFS | FSQRSRDESA | 
    200:
    SETSTPSEHS | AAPSPQVEVR | TLEGQLVQHP | GPGIPRPGHR | SRAPELVTKK | 
    250:
    FPVDLRLPPV | VPLPPPTLRE | LELQRRPTGD | FGFSLRRTTM | LDRGPEGQAC | 
    300:
    RRVVHFAEPG | AGTKDLALGL | VPGDRLVEIN | GHNVESKSRD | EIVEMIRQSG | 
    350:
    DSVRLKVQPI | PELSELSRSW | LRSGEGPRRE | PSDAKTEEQI | AAEEAWNETE | 
    400:
    KVWLVHRDGF | SLASQLKSEE | LNLPEGKVRV | KLDHDGAILD | VDEDDVEKAN | 
    450:
    APSCDRLEDL | ASLVYLNESS | VLHTLRQRYG | ASLLHTYAGP | SLLVLGPRGA | 
    500:
    PAVYSEKVMH | MFKGCRREDM | APHIYAVAQT | AYRAMLMSRQ | DQSIILLGSS | 
    550:
    GSGKTTSCQH | LVQYLATIAG | ISGNKVFSVE | KWQALYTLLE | AFGNSPTIIN | 
    600:
    GNATRFSQIL | SLDFDQAGQV | ASASIQTMLL | EKLRVARRPA | SEATFNVFYY | 
    650:
    LLACGDGTLR | TELHLNHLAE | NNVFGIVPLA | KPEEKQKAAQ | QFSKLQAAMK | 
    700:
    VLGISPDEQK | ACWFILAAIY | HLGAAGATKE | AAEAGRKQFA | RHEWAQKAAY | 
    750:
    LLGCSLEELS | SAIFKHQHKG | GTLQRSTSFR | QGPEESGLGD | GTGPKLSALE | 
    800:
    CLEGMAAGLY | SELFTLLVSL | VNRALKSSQH | SLCSMMIVDT | PGFQNPEQGG | 
    850:
    SARGASFEEL | CHNYTQDRLQ | RLFHERTFVQ | ELERYKEENI | ELAFDDLEPP | 
    900:
    TDDSVAAVDQ | ASHQSLVRSL | ARTDEARGLL | WLLEEEALVP | GASEDTLLER | 
    950:
    LFSYYGPQEG | DKKGQSPLLH | SSKPHHFLLG | HSHGTNWVEY | NVTGWLNYTK | 
    1000:
    QNPATQNAPR | LLQDSQKKII | SNLFLGRAGS | ATVLSGSIAG | LEGGSQLALR | 
    1050:
    RATSMRKTFT | TGMAAVKKKS | LCIQMKLQVD | ALIDTIKKSK | LHFVHCFLPV | 
    1100:
    AEGWAGEPRS | ASSRRVSSSS | ELDLPSGDHC | EAGLLQLDVP | LLRTQLRGSR | 
    1150:
    LLDAMRMYRQ | GYPDHMVFSE | FRRRFDVLAP | HLTKKHGRNY | IVVDERRAVE | 
    1200:
    ELLECLDLEK | SSCCMGLSRV | FFRAGTLARL | EEQRDEQTSR | NLTLFQAACR | 
    1250:
    GYLARQHFKK | RKIQDLAIRC | VQKNIKKNKG | VKDWPWWKLF | TTVRPLIEVQ | 
    1300:
    LSEEQIRNKD | EEIQQLRSKL | EKAEKERNEL | RLNSDRLESR | ISELTSELTD | 
    1350:
    ERNTGESASQ | LLDAETAERL | RAEKEMKELQ | TQYDALKKQM | EVMEMEVMEA | 
    1400:
    RLIRAAEING | EVDDDDAGGE | WRLKYERAVR | EVDFTKKRLQ | QEFEDKLEVE | 
    1450:
    QQNKRQLERR | LGDLQADSEE | SQRALQQLKK | KCQRLTAELQ | DTKLHLEGQQ | 
    1500:
    VRNHELEKKQ | RRFDSELSQA | HEEAQREKLQ | REKLQREKDM | LLAEAFSLKQ | 
    1550:
    QLEEKDMDIA | GFTQKVVSLE | AELQDISSQE | SKDEASLAKV | KKQLRDLEAK | 
    1600:
    VKDQEEELDE | QAGTIQMLEQ | AKLRLEMEME | RMRQTHSKEM | ESRDEEVEEA | 
    1650:
    RQSCQKKLKQ | MEVQLEEEYE | DKQKVLREKR | ELEGKLATLS | DQVNRRDFES | 
    1700:
    EKRLRKDLKR | TKALLADAQL | MLDHLKNSAP | SKREIAQLKN | QLEESEFTCA | 
    1750:
    AAVKARKAME | VEIEDLHLQI | DDIAKAKTAL | EEQLSRLQRE | KNEIQNRLEE | 
    1800:
    DQEDMNELMK | KHKAAVAQAS | RDLAQINDLQ | AQLEEANKEK | QELQEKLQAL | 
    1850:
    QSQVEFLEQS | MVDKSLVSRQ | EAKIRELETR | LEFERTQVKR | LESLASRLKE | 
    1900:
    NMEKLTEERD | QRIAAENREK | EQNKRLQRQL | RDTKEEMGEL | ARKEAEASRK | 
    1950:
    KHELEMDLES | LEAANQSLQA | DLKLAFKRIG | DLQAAIEDEM | ESDENEDLIN | 
    2000:
    SLQDMVTKYQ | KRKNKLEGDS | DVDSELEDRV | DGVKSWLSKN | KGPSKAASDD | 
    2050:
    GSLKSSSPTS | YWKSLAPDRS | DDEHDPLDNT | SRPRYSHSYL | SDSDTEAKLT | 
    2054:
    ETNA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Myosin-XVIIIa
    ELISA Kit for Human Myosin-XVIIIa
    CLIA Kit for Human Myosin-XVIIIa
    CLIA Kit for Human Myosin-XVIIIa
    Polyclonal Antibody for Human Myosin-XVIIIa
    Polyclonal Antibody for Human Myosin-XVIIIa
    Monoclonal Antibody for Human Myosin-XVIIIa
    Monoclonal Antibody for Human Myosin-XVIIIa
    Protein for Human Myosin-XVIIIa
    Protein for Human Myosin-XVIIIa

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Alternative splice variants encoding unstable protein domains exist in the human brain."
      Homma K. , Kikuno R.F. , Nagase T. , Ohara O. , Nishikawa K.
      J. Mol. Biol.343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);NUCLEOTIDE SEQUENCE [MRNA] OF 9-2054 (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T. , Seki N. , Ishikawa K. , Ohira M. , Kawarabayasi Y. , Ohara O. , Tanaka A. , Kotani H. , Miyajima N. , Nomura N.
      DNA Res.3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT VAL-958
      tissue: Brain.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Amygdala.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT VAL-958
      tissue: Testis.
    5. 5.
      "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival."
      Ji H. , Zhai Q. , Zhu J. , Yan M. , Sun L. , Liu X. , Zheng Z.
      Biochem. Biophys. Res. Commun.270:267-271(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAK3
    6. 6.
      "Genome structure and differential expression of two isoforms of a novel PDZ-containing myosin (MysPDZ) (Myo18A)."
      Mori K. , Furusawa T. , Okubo T. , Inoue T. , Ikawa S. , Yanai N. , Mori K.J. , Obinata M.
      J. Biochem.133:405-413(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)
    7. 7.
      "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site."
      Isogawa Y. , Kon T. , Inoue T. , Ohkura R. , Yamakawa H. , Ohara O. , Sutoh K.
      Biochemistry44:6190-6196(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;HOMODIMERIZATION;INTERACTION WITH ACTIN;MUTAGENESIS OF 114-ARG-GLY-115 AND 117-VAL-LEU-118
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "A tripartite complex containing MRCK modulates lamellar actomyosin retrograde flow."
      Tan I. , Yong J. , Dong J.M. , Lim L. , Leung T.
      Cell135:123-136(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH LURAP1 AND CDC42BPA/CDC42BPB
    10. 10.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2020;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Platelet.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1070; SER-1998; SER-2002; SER-2020; SER-2041; SER-2043 AND THR-2045;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."
      Han G. , Ye M. , Zhou H. , Jiang X. , Feng S. , Jiang X. , Tian R. , Wan D. , Zou H. , Gu J.
      Proteomics8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1970 AND SER-1974;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    14. 14.
      "GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding."
      Dippold H.C. , Ng M.M. , Farber-Katz S.E. , Lee S.K. , Kerr M.L. , Peterman M.C. , Sim R. , Wiharto P.A. , Galbraith K.A. , Madhavarapu S. , Fuchs G.J. , Meerloo T. , Farquhar M.G. , Zhou H. , Field S.J.
      Cell139:337-351(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GOLGI MEMBRANE BUDDING;INTERACTION WITH GOLPH3;SUBCELLULAR LOCATION
    15. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2041 AND SER-2043;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-140; SER-2041 AND SER-2043;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-140; SER-1970; SER-2007; SER-2041 AND SER-2043;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "Functional Characterization of Human Myosin-18A and its Interaction with F-actin and GOLPH3."
      Taft M.H. , Behrmann E. , Munske-Weidemann L.C. , Thiel C. , Raunser S. , Manstein D.J.
      J. Biol. Chem.288:30029-30041(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GOLPH3;F-ACTIN-BINDING;NUCLEOTIDE-BINDING;DOMAIN
    20. 20.
      "GOLPH3L antagonizes GOLPH3 to determine Golgi morphology."
      Ng M.M. , Dippold H.C. , Buschman M.D. , Noakes C.J. , Field S.J.
      Mol. Biol. Cell24:796-808(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GOLPH3
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