Gene name:
Grin1 (Nmdar1) ;
Protein name:
Glutamate [NMDA] receptor subunit zeta-1 (GluN1) ;
Alternative:
N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;N-methyl-D-aspartate receptor subunit NR1 (NMD-R1) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked (By similarity). Found in a complex with GRIN2A or GRIN2B, GRIN3A and PPP2CB. Found in a complex with GRIN2A or GRIN2B and GRIN3B (By similarity). Interacts with DLG4 and MPDZ. Interacts with LRFN1 and LRFN2. Interacts with GCOM1.
Function:
NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
synapse
postsynaptic cell membrane
Cell junction
synapse
postsynaptic cell membrane
postsynaptic density
Enriched in post-synaptic plasma membrane and post-synaptic densities.
Protein Attributes:
50:
MSTMHLLTFA | LLFSCSFARA | ACDPKIVNIG | AVLSTRKHEQ | MFREAVNQAN |
100:
KRHGSWKIQL | NATSVTHKPN | AIQMALSVCE | DLISSQVYAI | LVSHPPTPND |
150:
HFTPTPVSYT | AGFYRIPVLG | LTTRMSIYSD | KSIHLSFLRT | VPPYSHQSSV |
200:
WFEMMRVYNW | NHIILLVSDD | HEGRAAQKRL | ETLLEERESK | AEKVLQFDPG |
250:
TKNVTALLME | ARELEARVII | LSASEDDAAT | VYRAAAMLNM | TGSGYVWLVG |
300:
EREISGNALR | YAPDGIIGLQ | LINGKNESAH | ISDAVGVVAQ | AVHELLEKEN |
350:
ITDPPRGCVG | NTNIWKTGPL | FKRVLMSSKY | ADGVTGRVEF | NEDGDRKFAN |
400:
YSIMNLQNRK | LVQVGIYNGT | HVIPNDRKII | WPGGETEKPR | GYQMSTRLKI |
450:
VTIHQEPFVY | VKPTMSDGTC | KEEFTVNGDP | VKKVICTGPN | DTSPGSPRHT |
500:
VPQCCYGFCI | DLLIKLARTM | NFTYEVHLVA | DGKFGTQERV | NNSNKKEWNG |
550:
MMGELLSGQA | DMIVAPLTIN | NERAQYIEFS | KPFKYQGLTI | LVKKEIPRST |
600:
LDSFMQPFQS | TLWLLVGLSV | HVVAVMLYLL | DRFSPFGRFK | VNSEEEEEDA |
650:
LTLSSAMWFS | WGVLLNSGIG | EGAPRSFSAR | ILGMVWAGFA | MIIVASYTAN |
700:
LAAFLVLDRP | EERITGINDP | RLRNPSDKFI | YATVKQSSVD | IYFRRQVELS |
750:
TMYRHMEKHN | YESAAEAIQA | VRDNKLHAFI | WDSAVLEFEA | SQKCDLVTTG |
800:
ELFFRSGFGI | GMRKDSPWKQ | NVSLSILKSH | ENGFMEDLDK | TWVRYQECDS |
850:
RSNAPATLTF | ENMAGVFMLV | AGGIVAGIFL | IFIEIAYKRH | KDARRKQMQL |
900:
AFAAVNVWRK | NLQDRKSGRA | EPDPKKKATF | RAITSTLASS | FKRRRSSKDT |
938:
STGGGRGALQ | NQKDTVLPRR | AIEREEGQLQ | LCSRHRES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Dog
Polyclonal Antibody for Rat GluN1
Polyclonal Antibody for Rat GluN1
Polyclonal Antibody for Rat GluN1
Polyclonal Antibody for Rat GluN1
Monoclonal Antibody for Rat GluN1
Monoclonal Antibody for Rat GluN1
Monoclonal Antibody for Rat GluN1
Monoclonal Antibody for Rat GluN1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Forebrain .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-86
strain :
Sprague-Dawley .
tissue :
Liver .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-897;DEPHOSPHORYLATION BY PPP2CB;IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B; GRIN3A AND PPP2CB
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHARACTERIZATION;IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
10.
"Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons."
Sasaki Y.F.
,
Rothe T.
,
Premkumar L.S.
,
Das S.
,
Cui J.
,
Talantova M.V.
,
Wong H.-K.
,
Gong X.
,
Chan S.F.
,
Zhang D.
,
Nakanishi N.
,
Sucher N.J.
,
Lipton S.A.
J. Neurophysiol.87:2052-2063(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN A COMPLEX WITH GRIN2A OR GRIN2B AND GRIN3A
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MPDZ AND DLG4
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-890
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LRFN2
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH LRFN1
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MYZAP
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 394-800 IN COMPLEXES WITH AGONISTS AND ANTAGONIST
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 394-800 IN COMPLEX WITH GRIN2A; GLYCINE AND GLUTAMATE;SUBUNIT
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 394-800 IN COMPLEXES WITH AGONISTS;FUNCTION