Protein name:
Nuclear receptor subfamily 1 group I member 2 ;
Alternative:
Pregnane X receptor ;Orphan nuclear receptor PXR ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterodimer with RXRA. Interacts with NCOA1.
Function:
Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).
Subcellular Location:
Nucleus
Protein Attributes:
50:
MRPEESWSRV | GLVQCEEADS | ALEEPINVEE | EDGGLQICRV | CGDKANGYHF |
100:
NVMTCEGCKG | FFRRAMKRNV | RLRCPFRKGT | CEITRKTRRQ | CQACRLRKCL |
150:
ESGMKKEMIM | SDAAVEQRRA | LIKRKKREKI | EAPPPGGQGL | TEEQQALIQE |
200:
LMDAQMQTFD | TTFSHFKDFR | LPAVFHSGCE | LPEFLQASLL | EDPATWSQIM |
250:
KDRVPMKISL | QLRGEDGSIW | NYQPPSKSDG | KEIIPLLPHL | ADVSTYMFKG |
300:
VINFAKVISY | FRDLPIEDQI | SLLKGATFEM | CILRFNTMFD | TETGTWECGR |
350:
LAYCFEDPNG | GFQKLLLDPL | MKFHCMLKKL | QLHKEEYVLM | QAISLFSPDR |
400:
PGVVQRSVVD | QLQERFALTL | KAYIECSRPY | PAHRFLFLKI | MAVLTELRSI |
431:
NAQQTQQLLR | IQDSHPFATP | LMQELFSSTD | G
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
ELISA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
ELISA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
CLIA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
CLIA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
CLIA Kit for Mouse Nuclear receptor subfamily 1 group I member 2
Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Polyclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Monoclonal Antibody for Mouse Nuclear receptor subfamily 1 group I member 2
Protein for Mouse Nuclear receptor subfamily 1 group I member 2
Protein for Mouse Nuclear receptor subfamily 1 group I member 2
Protein for Mouse Nuclear receptor subfamily 1 group I member 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Litwa E, Rzemieniec J, Wnuk A, et al.
References
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"An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway."
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Cell92:73-82(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
tissue :
Liver .
2.
"The transcriptional landscape of the mammalian genome."
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Cecum .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION