Gene name:
NRG1 (GGF;HGL;HRGA;NDF;SMDF) ;
Protein name:
Pro-neuregulin-1, membrane-bound isoform (Pro-NRG1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The cytoplasmic domain interacts with the LIM domain region of LIMK1.
Function:
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
Subcellular Location:
Isoform 10
Membrane
Single-pass type I membrane protein
May possess an internal uncleaved signal sequence.
Protein Attributes:
50:
MSERKEGRGK | GKGKKKERGS | GKKPESAAGS | QSPALPPRLK | EMKSQESAAG |
100:
SKLVLRCETS | SEYSSLRFKW | FKNGNELNRK | NKPQNIKIQK | KPGKSELRIN |
150:
KASLADSGEY | MCKVISKLGN | DSASANITIV | ESNEIITGMP | ASTEGAYVSS |
200:
ESPIRISVST | EGANTSSSTS | TSTTGTSHLV | KCAEKEKTFC | VNGGECFMVK |
250:
DLSNPSRYLC | KCQPGFTGAR | CTENVPMKVQ | NQEKAEELYQ | KRVLTITGIC |
300:
IALLVVGIMC | VVAYCKTKKQ | RKKLHDRLRQ | SLRSERNNMM | NIANGPHHPN |
350:
PPPENVQLVN | QYVSKNVISS | EHIVEREAET | SFSTSHYTST | AHHSTTVTQT |
400:
PSHSWSNGHT | ESILSESHSV | IVMSSVENSR | HSSPTGGPRG | RLNGTGGPRE |
450:
CNSFLRHARE | TPDSYRDSPH | SERYVSAMTT | PARMSPVDFH | TPSSPKSPPS |
500:
EMSPPVSSMT | VSMPSMAVSP | FMEEERPLLL | VTPPRLREKK | FDHHPQQFSS |
550:
FHHNPAHDSN | SLPASPLRIV | EDEEYETTQE | YEPAQEPVKK | LANSRRAKRT |
600:
KPNGHIANRL | EVDSNTSSQS | SNSESETEDE | RVGEDTPFLG | IQNPLAASLE |
640:
ATPAFRLADS | RTNPAGRFST | QEEIQARLSS | VIANQDPIAV |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Chicken
ELISA Kit for Human Pro-NRG1
ELISA Kit for Human Pro-NRG1
ELISA Kit for Human Pro-NRG1
CLIA Kit for Human Pro-NRG1
CLIA Kit for Human Pro-NRG1
CLIA Kit for Human Pro-NRG1
Polyclonal Antibody for Human Pro-NRG1
Polyclonal Antibody for Human Pro-NRG1
Polyclonal Antibody for Human Pro-NRG1
Monoclonal Antibody for Human Pro-NRG1
Monoclonal Antibody for Human Pro-NRG1
Monoclonal Antibody for Human Pro-NRG1
Protein for Human Pro-NRG1
Protein for Human Pro-NRG1
Protein for Human Pro-NRG1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Ji Fei Zhang , Fu Sheng Zhao, Geng Wu, Qing Fei Kong, Bo Sun, Jingyan Cao, Yao Zhang, Jing Hua Wang, Jing Zhang, Xu Dong Jin , Hu Lun Li
[2].
JF Zhang, FS Zhao, G Wu, et al.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 10 AND 12);VARIANT THR-289
tissue :
Hippocampus .
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF GAMMA-HEREGULIN FUSION PROTEIN
tissue :
Mammary cancer .
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Am. J. Hum. Genet.71:877-892(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 3; 8 AND 9);SUSCEPTIBILITY TO SCHIZOPHRENIA
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 11);ALTERNATIVE SPLICING;VARIANTS GLN-38 AND THR-289;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
tissue :
Hippocampus .
tissue :
Prefrontal cortex .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 10)
tissue :
Brain .
tissue :
Duodenum .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-211 (ISOFORM 1)
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 20-28
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE (ISOFORM 1);FUNCTION;GLYCOSYLATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ERBB4;FUNCTION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CHROMOSOMAL TRANSLOCATION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ERBB4
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 175-241 (ISOFORM 1)
20.
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Cited for : STRUCTURE BY NMR OF 177-239 (ISOFORM 1);DISULFIDE BONDS