Protein name:
Pappalysin-1 ;
Alternative:
Pregnancy-associated plasma protein A (PAPP-A) ;Insulin-like growth factor-dependent IGF-binding protein 4 protease (IGF-dependent IGFBP-4 protease;IGFBP-4ase) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked. In pregnancy serum, predominantly found as a disulfide-linked 2:2 heterotetramer with the proform of PRG2.
Function:
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF.
Subcellular Location:
Secreted
Protein Attributes:
50:
MRLWSWVLHL | GLLSAALGCG | LAERPRRARR | DPRAGRPPRP | AAGPATCATR |
100:
AARGRRASPP | PPPPPGGAWE | AVRVPRRRQQ | REARGATEEP | SPPSRALYFS |
150:
GRGEQLRLRA | DLELPRDAFT | LQVWLRAEGG | QRSPAVITGL | YDKCSYISRD |
200:
RGWVVGIHTI | SDQDNKDPRY | FFSLKTDRAR | QVTTINAHRS | YLPGQWVYLA |
250:
ATYDGQFMKL | YVNGAQVATS | GEQVGGIFSP | LTQKCKVLML | GGSALNHNYR |
300:
GYIEHFSLWK | VARTQREILS | DMETHGAHTA | LPQLLLQENW | DNVKHAWSPM |
350:
KDGSSPKVEF | SNAHGFLLDT | SLEPPLCGQT | LCDNTEVIAS | YNQLSSFRQP |
400:
KVVRYRVVNL | YEDDHKNPTV | TREQVDFQHH | QLAEAFKQYN | ISWELDVLEV |
450:
SNSSLRRRLI | LANCDISKIG | DENCDPECNH | TLTGHDGGDC | RHLRHPAFVK |
500:
KQHNGVCDMD | CNYERFNFDG | GECCDPEITN | VTQTCFDPDS | PHRAYLDVNE |
550:
LKNILKLDGS | THLNIFFAKS | SEEELAGVAT | WPWDKEALMH | LGGIVLNPSF |
600:
YGMPGHTHTM | IHEIGHSLGL | YHVFRGISEI | QSCSDPCMET | EPSFETGDLC |
650:
NDTNPAPKHK | SCGDPGPGND | TCGFHSFFNT | PYNNFMSYAD | DDCTDSFTPN |
700:
QVARMHCYLD | LVYQGWQPSR | KPAPVALAPQ | VLGHTTDSVT | LEWFPPIDGH |
750:
FFERELGSAC | HLCLEGRILV | QYASNASSPM | PCSPSGHWSP | REAEGHPDVE |
800:
QPCKSSVRTW | SPNSAVNPHT | VPPACPEPQG | CYLELEFLYP | LVPESLTIWV |
850:
TFVSTDWDSS | GAVNDIKLLA | VSGKNISLGP | QNVFCDVPLT | IRLWDVGEEV |
900:
YGIQIYTLDE | HLEIDAAMLT | STADTPLCLQ | CKPLKYKVVR | DPPLQMDVAS |
950:
ILHLNRKFVD | MDLNLGSVYQ | YWVITISGTE | ESEPSPAVTY | IHGSGYCGDG |
1000:
IIQKDQGEQC | DDMNKINGDG | CSLFCRQEVS | FNCIDEPSRC | YFHDGDGVCE |
1050:
EFEQKTSIKD | CGVYTPQGFL | DQWASNASVS | HQDQQCPGWV | IIGQPAASQV |
1100:
CRTKVIDLSE | GISQHAWYPC | TISYPYSQLA | QTTFWLRAYF | SQPMVAAAVI |
1150:
VHLVTDGTYY | GDQKQETISV | QLLDTKDQSH | DLGLHVLSCR | NNPLIIPVVH |
1200:
DLSQPFYHSQ | AVRVSFSSPL | VAISGVALRS | FDNFDPVTLS | SCQRGETYSP |
1250:
AEQSCVHFAC | EKTDCPELAV | ENASLNCSSS | DRYHGAQCTV | SCRTGYVLQI |
1300:
RRDDELIKSQ | TGPSVTVTCT | EGKWNKQVAC | EPVDCSIPDH | HQVYAASFSC |
1350:
PEGTTFGSQC | SFQCRHPAQL | KGNNSLLTCM | EDGLWSFPEA | LCELMCLAPP |
1400:
PVPNADLQTA | RCRENKHKVG | SFCKYKCKPG | YHVPGSSRKS | KKRAFKTQCT |
1450:
QDGSWQEGAC | VPVTCDPPPP | KFHGLYQCTN | GFQFNSECRI | KCEDSDASQG |
1500:
LGSNVIHCRK | DGTWNGSFHV | CQEMQGQCSV | PNELNSNLKL | QCPDGYAIGS |
1550:
ECATSCLDHN | SESIILPMNV | TVRDIPHWLN | PTRVERVVCT | AGLKWYPHPA |
1600:
LIHCVKGCEP | FMGDNYCDAI | NNRAFCNYDG | GDCCTSTVKT | KKVTPFPMSC |
1627:
DLQGDCACRD | PQAQEHSRKD | LRGYSHG
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Human Pappalysin-1
ELISA Kit for Human Pappalysin-1
CLIA Kit for Human Pappalysin-1
CLIA Kit for Human Pappalysin-1
Polyclonal Antibody for Human Pappalysin-1
Polyclonal Antibody for Human Pappalysin-1
Monoclonal Antibody for Human Pappalysin-1
Monoclonal Antibody for Human Pappalysin-1
Protein for Human Pappalysin-1
Protein for Human Pappalysin-1
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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Citations
[1].
H Wang, Y Song, C Zhang, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INDUCTION;VARIANT ARG-944
tissue :
Placenta .
2.
"DNA sequence and analysis of human chromosome 9."
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[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT TYR-1224
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 77-1627;PROTEIN SEQUENCE OF 81-98; 117-126; 210-224; 466-485; 507-519; 576-593; 609-621; 718-736; 742-754; 1006-1017; 1259-1273; 1369-1374; 1389-1398; 1490-1509; 1524-1533 AND 1537-1544;VARIANT ARG-944;TISSUE SPECIFICITY
tissue :
Placenta .
tissue :
Serum .
5.
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Cited for : PROTEIN SEQUENCE OF 81-89; 117-126; 210-224; 460-485; 507-519; 576-593; 718-736; 742-754; 1259-1273; 1369-1374; 1490-1509; 1524-1533 AND 1537-1544;SUBUNIT;INTERCHAIN DISULFIDE BOND
tissue :
Serum .
6.
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Cited for : PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION AT ASN-402; ASN-429; ASN-480; ASN-601; ASN-619; ASN-725; ASN-1026; ASN-1226; ASN-1323 AND ASN-1519;DISULFIDE BONDS
7.
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Cited for : IDENTIFICATION;FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue :
Fibroblast .
8.
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Cited for : FUNCTION;SUBUNIT;ENZYME REGULATION
9.
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Cited for : TISSUE SPECIFICITY
10.
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Cited for : TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
11.
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Cited for : DEVELOPMENTAL STAGE
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT TYR-1224