Ptgs2 ELISA Kit for Mouse(Mus musculus) | EIAab.comPtgs2 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Ptgs2(Gene name) > Mouse

Ptgs2 (Gene name),

Prostaglandin G/H synthase 2 (Protein name ), PGH2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

Ptgs2(Cox-2;Cox2;Pghs-b;Tis10);

Protein name:

Prostaglandin G/H synthase 2;

Alternative:

Glucocorticoid-regulated inflammatory cyclooxygenase;Cyclooxygenase-2(COX-2);Macrophage activation-associated marker protein P71/73;Gripghs;PHS II;PES-2;Prostaglandin-endoperoxide synthase 2;Prostaglandin H2 synthase 2(PGH synthase 2;PGHS-2);TIS10 protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer.

Function:

Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.

Subcellular Location:

Microsome membrane Peripheral membrane protein Endoplasmic reticulum membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

604

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

604:

STEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.292547

String:

Q05769

SMR:

Q05769

KEGG:

mmu:19225

Pfam:

PF03098

Uniprot:

Q05769

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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E0699h

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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E0699r

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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E0699b

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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E0699m

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ELISA Kit for Mouse Prostaglandin G/H synthase 2

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

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U0699b

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

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U0699m

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

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U0699c

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

MSDS:

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

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U0699r

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Looking for manual.

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96T

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CLIA Kit for Mouse Prostaglandin G/H synthase 2

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U0699h

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Polyclonal Antibody for Mouse Prostaglandin G/H synthase 2

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P0699Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse Prostaglandin G/H synthase 2

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P0699Rb-r

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Polyclonal Antibody for Mouse Prostaglandin G/H synthase 2

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P0699Rb-m

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Monoclonal Antibody for Mouse Prostaglandin G/H synthase 2

Protein for Mouse Prostaglandin G/H synthase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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Citations

[1].

"S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent ..."

J Xiao, E C Liong, M T Ling et al.

From:Eur J Nutr

References

1.

"TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue."
Kujubu D.A. , Fletcher B.S. , Varnum B.C. , Lim R.W. , Herschman H.R.
J. Biol. Chem.266:12866-12872(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Swiss.
2.

"Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase."
Fletcher B.S. , Kujubu D.A. , Perrin D.M. , Herschman H.R.
J. Biol. Chem.267:4338-4344(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Identification of an immediate early gene, pghs-B, whose protein product has prostaglandin synthase/cyclooxygenase activity."
Ryseck R.-P. , Raynoschek C. , Macdonald-Bravo H. , Dorfman K. , Mattei M.-G. , Bravo R.
Cell Growth Differ.3:443-450(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase."
O'Banion M.K. , Winn V.D. , Young D.A.
Proc. Natl. Acad. Sci. U.S.A.89:4888-4892(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
strain: NOD.
tissue: Hippocampus.
tissue: Mammary gland.
tissue: Spleen.
6.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein."
O'Banion M.K. , Sadowski H.B. , Winn V. , Young D.A.
J. Biol. Chem.266:23261-23267(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 281-360
8.

"The mouse macrophage activation-associated marker protein, p71/73, is an inducible prostaglandin endoperoxide synthase (cyclooxygenase)."
Phillips T.A. , Kujubu D.A. , Mackay R.J. , Herschman H.R. , Russell S.W. , Pace J.L.
J. Leukoc. Biol.53:411-419(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE
9.

"N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum."
Otto J.C. , Dewitt D.L. , Smith W.L.
J. Biol. Chem.268:18234-18242(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-53; ASN-130; ASN-396 AND ASN-580;ABSENCE OF GLYCOSYLATION AT ASN-592
10.

"Igf2bp1 is required for full induction of Ptgs2 mRNA in colonic mesenchymal stem cells in mice."
Manieri N.A. , Drylewicz M.R. , Miyoshi H. , Stappenbeck T.S.
Gastroenterology143:110-121(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN INTESTINAL WOUND REPAIR;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
11.

"Cyclooxygenases: structural, cellular, and molecular biology."
Smith W.L. , DeWitt D.L. , Garavito R.M.
Annu. Rev. Biochem.69:145-182(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; TISSUE SPECIFICITY AND INHIBITION BY NSAIDS
12.

"Aspirin, cyclooxygenase inhibition and colorectal cancer."
Sostres C. , Gargallo C.J. , Lanas A.
World J. Gastrointest. Pharmacol. Ther.5:40-49(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION; INHIBITION BY ASPIRIN AND INVOLVEMENT IN COLORECTAL CANCER
13.

"Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents."
Kurumbail R.G. , Stevens A.M. , Gierse J.K. , McDonald J.J. , Stegeman R.A. , Pay J.Y. , Gildehaus D. , Miyashiro J.M. , Penning T.D. , Seibert K. , Isakson P.C. , Stallings W.C.
Nature384:644-648(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEX WITH (S)-FLURBIPROFEN; INDOMETHACIN; HEME AND 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE;COFACTOR;GLYCOSYLATION AT ASN-53; ASN-130 AND ASN-396
14.

Kurumbail R.G. , Stevens A.M. , Gierse J.K. , McDonald J.J. , Stegeman R.A. , Pay J.Y. , Gildehaus D. , Miyashiro J.M. , Penning T.D. , Seibert K. , Isakson P.C. , Stallings W.C.
Nature385:555-555(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
15.

"Structural insights into the stereochemistry of the cyclooxygenase reaction."
Kiefer J.R. , Pawlitz J.L. , Moreland K.T. , Stegeman R.A. , Hood W.F. , Gierse J.K. , Stevens A.M. , Goodwin D.C. , Rowlinson S.W. , Marnett L.J. , Stallings W.C. , Kurumbail R.G.
Nature405:97-101(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 18-569 IN COMPLEX WITH ARACHIDONIC ACID;GLYCOSYLATION AT ASN-53; ASN-130 AND ASN-396
16.

"A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385."
Rowlinson S.W. , Kiefer J.R. , Prusakiewicz J.J. , Pawlitz J.L. , Kozak K.R. , Kalgutkar A.S. , Stallings W.C. , Kurumbail R.G. , Marnett L.J.
J. Biol. Chem.278:45763-45769(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS) IN COMPLEX WITH HEME AND DICLOFENAC;CATALYTIC ACTIVITY;FUNCTION;COFACTOR;DISULFIDE BONDS;ENZYME REGULATION;GLYCOSYLATION AT ASN-53; ASN-130 AND ASN-396
17.

"Structural basis of fatty acid substrate binding to cyclooxygenase-2."
Vecchio A.J. , Simmons D.M. , Malkowski M.G.
J. Biol. Chem.285:22152-22163(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 20-604 IN COMPLEX WITH HEME; ACRYLIC ACID; ARACHIDONIC ACID AND DOCOSAHEXAENOIC ACID;CATALYTIC ACTIVITY;ACTIVE SITE;SUBUNIT;COFACTOR;FUNCTION;DISULFIDE BONDS;MUTAGENESIS OF LEU-517 AND ASN-580;GLYCOSYLATION AT ASN-53; ASN-130; ASN-396 AND ASN-580
18.

"Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen."
Duggan K.C. , Walters M.J. , Musee J. , Harp J.M. , Kiefer J.R. , Oates J.A. , Marnett L.J.
J. Biol. Chem.285:34950-34959(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.73 ANGSTROMS) OF 18-604 IN COMPLEXES WITH HEME AND NAPROXEN ANALOGS;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;DISULFIDE BONDS;GLYCOSYLATION AT ASN-53; ASN-130 AND ASN-396
19.

"The structural basis of endocannabinoid oxygenation by cyclooxygenase-2."
Vecchio A.J. , Malkowski M.G.
J. Biol. Chem.286:20736-20745(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 20-599 IN COMPLEX WITH HEME; ACRYLIC ACID AND ARACHIDONIC ACID;FUNCTION;CATALYTIC ACTIVITY;GLYCOSYLATION AT ASN-53; ASN-130 AND ASN-396

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