Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1 ;
Alternative:
Phospholipase C-zeta-1 (PLC-zeta-1) ;Phosphoinositide phospholipase C-zeta-1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts via its C2 domain with PtdIns(3)P and, to a lesser extent, PtdIns(5)P in vitro.
Function:
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.
Subcellular Location:
Nucleus
Cytoplasm
perinuclear region
Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis.
Protein Attributes:
50:
MESHYELAEA | RWFMSKIQDY | FRGGKISAGI | THKLLEKLDF | PCHFAHVKRI |
100:
FKENDRHNQG | RITTEDFRTI | YRCIVHREEI | VEIFNTYTEN | RKILPEDSLI |
150:
EFLTQEQYEM | EMDESSSVEI | IQKYEPIAEV | KNERQMSIEG | FARYMFSSEC |
200:
LLFKETCNTV | YQDMNKPLND | YYISSSHNTY | LISDQILGPS | DIWGYISALV |
250:
KGCRCLEIDC | WDGAQNEPIV | YHGYTLTSKL | LFKTVIQAIN | KYAFVTSDYP |
300:
VVLSLENHCS | PGQQEVMTDI | LQSTFGDFLL | SDILDEFPDS | LPSPEALKFK |
350:
ILVKNKKVGT | LSETRERLGT | DKRGIALDLE | EEIYENEDED | SGKEPETWDD |
400:
FLSRVKEEQE | ADPSTLSGIA | DAKKKIRKLR | VALALSDLVI | YTKAEKFRNF |
450:
QYSRVYQQFN | ETTSMGESRA | RKLSKLRAHE | FIFHTAAFIT | RVYPKFTRAD |
500:
SSNFNPQEFW | NVGCQMVALN | FQTPGLPMDL | QNGKFLDNGG | SGYVLKPDFL |
550:
RDTTLGFNPN | EPEGDGHPVT | LTIRLISGIQ | LPVNVPSNTS | DIIVIIEVYG |
600:
VPNDHMKQQS | RAVKNNAFSP | RWNETFTFLI | QVPELALIRF | VVETQGFLSG |
645:
NELLGQYTLP | VLCMNKGYRR | VPLFSKSGAN | LEPSSLFIYV | WYYRE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
ELISA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
CLIA Kit for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Polyclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Monoclonal Antibody for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
Protein for Rat 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase zeta-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
Saunders C.M.
Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Testis .
2.
"Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish."
Ito M.
,
Shikano T.
,
Oda S.
,
Horiguchi T.
,
Tanimoto S.
,
Awaji T.
,
Mitani H.
,
Miyazaki S.
Biol. Reprod.78:1081-1090(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION