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Index > Protein center > PON1(Gene name) > Human
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  • PON1 (Gene name),
  • Serum paraoxonase/arylesterase 1 (Protein name ),  PON1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    PON1(PON);
    Protein name:
    Serum paraoxonase/arylesterase 1(PON 1);
    Alternative:
    K-45;Aromatic esterase 1(A-esterase 1);Serum aryldialkylphosphatase 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.
    Function:
    Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
    Subcellular Location:
    Secreted extracellular space
    Protein Attributes:
    Sequence length:
    355
    Sequence:
    50:
    MAKLIALTLL | GMGLALFRNH | QSSYQTRLNA | LREVQPVELP | NCNLVKGIET | 
    100:
    GSEDLEILPN | GLAFISSGLK | YPGIKSFNPN | SPGKILLMDL | NEEDPTVLEL | 
    150:
    GITGSKFDVS | SFNPHGISTF | TDEDNAMYLL | VVNHPDAKST | VELFKFQEEE | 
    200:
    KSLLHLKTIR | HKLLPNLNDI | VAVGPEHFYG | TNDHYFLDPY | LQSWEMYLGL | 
    250:
    AWSYVVYYSP | SEVRVVAEGF | DFANGINISP | DGKYVYIAEL | LAHKIHVYEK | 
    300:
    HANWTLTPLK | SLDFNTLVDN | ISVDPETGDL | WVGCHPNGMK | IFFYDSENPP | 
    350:
    ASEVLRIQNI | LTEEPKVTQV | YAENGTVLQG | STVASVYKGK | LLIGTVFHKA | 
    355:
    LYCEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    MIM:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human PON 1
    Cat.:
    E0243r
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PON 1
    Cat.:
    E0243h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human PON 1
    Cat.:
    E0243m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human PON 1
    MSDS:
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    CLIA Kit for Human PON 1
    Cat.:
    U0243r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human PON 1
    Cat.:
    U0243h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human PON 1
    MSDS:
    Please sign in first.
    CLIA Kit for Human PON 1
    Cat.:
    U0243m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human PON 1
    Cat.:
    P0243Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PON 1
    Cat.:
    P0243Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PON 1
    Cat.:
    P0243Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human PON 1
    Monoclonal Antibody for Human PON 1
    Monoclonal Antibody for Human PON 1
    Monoclonal Antibody for Human PON 1
    Monoclonal Antibody for Human PON 1
    Protein for Human PON 1
    Protein for Human PON 1
    Protein for Human PON 1
    Protein for Human PON 1

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    Linearity
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    Citations
    [1].
    Ramadan R· Tawdy A · Abdel Hay R · Rashed L · Tawfik D
    From:Karger
    References
    1. 1.
      "Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence."
      Hassett C. , Richter R.J. , Humbert R. , Chapline C. , Crabb J.W. , Omiecinski C.J. , Furlong C.E.
      Biochemistry30:10141-10149(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS MET-55 AND ARG-192
      tissue: Liver.
    2. 2.
      "Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: glutamine or arginine at position 191, for the respective A or B allozymes."
      Adkins S. , Gan K.N. , Mody M. , La Du B.N.
      Am. J. Hum. Genet.52:598-608(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-55 AND ARG-192
    3. 3.
      "Studies on human serum paraoxonase/arylesterase."
      La Du B.N. , Adkins S. , Kuo C.L. , Lipsig D.
      Chem. Biol. Interact.87:25-34(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CATALYTIC ACTIVITY;VARIANTS MET-55 AND ARG-192
      tissue: Liver.
    4. 4.
      "Human and rabbit paraoxonases: purification, cloning, sequencing, mapping and role of polymorphism in organophosphate detoxification."
      Furlong C.E. , Costa L.G. , Hassett C. , Richter R.J. , Sundstrom J.A. , Adler D.A. , Disteche C.M. , Omiecinski C.J. , Chapline C. , Crabb J.W.
      Chem. Biol. Interact.87:35-48(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS MET-55 AND ARG-192;CHARACTERIZATION
      tissue: Liver.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-55
      tissue: Lymphoblast.
    6. 6.
      "Differential expression of a cDNA clone in human liver versus hepatic cancer -- highly homologous to aryl-dialkyl-phosphatase."
      Wang K.K. , Wan D.F. , Qiu X.K. , Lu P.X. , Gu J.R.
      Cell Res.7:79-90(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-55
      tissue: Liver.
    8. 8.
      SeattleSNPs variation discovery resource
      Submitted (2002-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-192
    9. 9.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    12. 13.
      "Identification of a distinct human high-density lipoprotein subspecies defined by a lipoprotein-associated protein, K-45. Identity of K-45 with paraoxonase."
      Blatter M.-C. , James R.W. , Messmer S. , Barja F. , Pometta D.
      Eur. J. Biochem.211:871-879(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21;TISSUE SPECIFICITY
    13. 14.
      "Apolipoprotein J is associated with paraoxonase in human plasma."
      Kelso G.J. , Stuart W.D. , Richter R.J. , Furlong C.E. , Jordan-Starck T.C. , Harmony J.A.K.
      Biochemistry33:832-839(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21; 234-244; 291-305 AND 350-355;INTERACTION WITH CLU;TISSUE SPECIFICITY;DISULFIDE BOND
      tissue: Plasma.
    14. 15.
      "Purification of rabbit and human serum paraoxonase."
      Furlong C.E. , Richter R.J. , Chapline C. , Crabb J.W.
      Biochemistry30:10133-10140(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-11;CATALYTIC ACTIVITY
    15. 16.
      "Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities."
      Gan K.N. , Smolen A. , Eckerson H.W. , La Du B.N.
      Drug Metab. Dispos.19:100-106(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
    16. 17.
      "Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase."
      Sorenson R.C. , Primo-Parmo S.L. , Kuo C.-L. , Adkins S. , Lockridge O. , La Du B.N.
      Proc. Natl. Acad. Sci. U.S.A.92:7187-7191(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-284
    17. 18.
      "Human serum paraoxonase/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: apolipoprotein A-I stabilizes activity."
      Sorenson R.C. , Bisgaier C.L. , Aviram M. , Hsu C. , Billecke S. , La Du B.N.
      Arterioscler. Thromb. Vasc. Biol.19:2214-2225(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 20-HIS-GLN-21;FUNCTION OF THE UNCLEAVED SIGNAL PEPTIDE
    18. 19.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-253
      tissue: Plasma.
    19. 20.
      "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
      Draganov D.I. , Teiber J.F. , Speelman A. , Osawa Y. , Sunahara R. , La Du B.N.
      J. Lipid Res.46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT
    20. 21.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-227; ASN-253 AND ASN-324
      tissue: Plasma.
    21. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HPBP
    22. 23.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-253 AND ASN-324
      tissue: Liver.
    23. 24.
      "Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes."
      Harel M. , Aharoni A. , Gaidukov L. , Brumshtein B. , Khersonsky O. , Meged R. , Dvir H. , Ravelli R.B.G. , McCarthy A. , Toker L. , Silman I. , Sussman J.L. , Tawfik D.S.
      Nat. Struct. Mol. Biol.11:412-419(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH CALCIUM IONS;MUTAGENESIS OF HIS-115 AND HIS-134;CATALYTIC ACTIVITY;DISULFIDE BOND
    24. 25.
      "The molecular basis of the human serum paraoxonase activity polymorphism."
      Humbert R. , Adler D.A. , Disteche C.M. , Hassett C. , Omiecinski C.J. , Furlong C.E.
      Nat. Genet.3:73-76(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ARG-192
    25. 26.
      "A variant of paraoxonase (PON1) gene is associated with diabetic retinopathy in IDDM."
      Kao Y.-L. , Donaghue K. , Chan A. , Knight J. , Silink M.
      J. Clin. Endocrinol. Metab.83:2589-2592(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH DIABETIC RETINOPATHY SUSCEPTIBILITY
    26. 27.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-102
    27. 28.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-192
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