Protein name:
Sclerostin;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling.
Function:
Negative regulator of bone growth.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQLSLAPCLA | CLLVHAAFVA | VESQGWQAFK | NDATEIIPGL | REYPEPPQEL |
100:
ENNQTMNRAE | NGGRPPHHPY | DTKDVSEYSC | RELHYTRFVT | DGPCRSAKPV |
150:
TELVCSGQCG | PARLLPNAIG | RVKWWRPNGP | DFRCIPDRYR | AQRVQLLCPG |
200:
GAAPRSRKVR | LVASCKCKRL | TRFHNQSELK | DFGPETARPQ | KGRKPRPRAR |
Vaild Sequence:
Related Databases
Uniprot:
FOR
ELISA Kit for Rat Sclerostin
ELISA Kit for Rat Sclerostin
ELISA Kit for Rat Sclerostin
ELISA Kit for Rat Sclerostin
CLIA Kit for Rat Sclerostin
CLIA Kit for Rat Sclerostin
CLIA Kit for Rat Sclerostin
CLIA Kit for Rat Sclerostin
Polyclonal Antibody for Rat Sclerostin
Polyclonal Antibody for Rat Sclerostin
Polyclonal Antibody for Rat Sclerostin
Polyclonal Antibody for Rat Sclerostin
Monoclonal Antibody for Rat Sclerostin
Monoclonal Antibody for Rat Sclerostin
Monoclonal Antibody for Rat Sclerostin
Monoclonal Antibody for Rat Sclerostin
Protein for Rat Sclerostin
Protein for Rat Sclerostin
Protein for Rat Sclerostin
Protein for Rat Sclerostin
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Juliana C. Ferreira, Guaraciaba O. Ferrari, Katia R. Neves, et al.
References
-
1.
"Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein."
Brunkow M.E.
,
Gardner J.C.
,
Van Ness J.
,
Paeper B.W.
,
Kovacevich B.R.
,
Proll S.
,
Skonier J.E.
,
Zhao L.
,
Sabo P.J.
,
Fu Y.H.
,
Alisch R.S.
,
Gillett L.
,
Colbert T.
,
Tacconi P.
,
Galas D.
,
Hamersma H.
,
Beighton P.
,
Mulligan J.T.
Am. J. Hum. Genet.68:577-589(2001)
[
PubMed]
[
Europe PMC]
[
Abstract]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain:
Sprague-Dawley.
-
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: DOWN-REGULATION BY PTH