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Index > Protein center > Steap4(Gene name) > Mouse
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  • Steap4 (Gene name),
  • Metalloreductase STEAP4 (Protein name ),  STEA4_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Steap4(Tiarp);
    Protein name:
    Metalloreductase STEAP4;
    Alternative:
    Six-transmembrane epithelial antigen of prostate 4;Dudulin-4;Tumor necrosis factor-alpha-induced adipose-related protein;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with and phosphorylates PTK2.
    Function:
    Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses.
    Subcellular Location:
    Cell membrane Golgi apparatus membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    470
    Sequence:
    50:
    MEKAHADEFP | LTTDSSEKQG | VVCIFGTGDF | GKSLGLKMLQ | CGYSIVFGSR | 
    100:
    NPQVSSLLPR | GAEVLSYSEA | ASKSDIIILA | MHREHYDSLT | ELVDYLKGKV | 
    150:
    LVDVSNNRKI | NQYPESNAEY | LAQLEPGAHV | VKAFNTISAW | ALQSGTLDAS | 
    200:
    RQVFVCGNDS | KAKQRVMDIA | RTLGLTPLDQ | GSLMAASEIE | NYPLQLFPMW | 
    250:
    RFPFYLSSVL | CVFFFVYCAI | REVIYPYVNG | KTDATYRLAI | SIPNRVFPIT | 
    300:
    ALILLALVYL | PGILAAILQL | YRGTKYRRFP | NWLDHWMLCR | KQLGLVALGF | 
    350:
    AFLHVIYTLV | IPIRYYVRWR | LRNATITQAL | TNKDSPFITS | YAWINDSYLA | 
    400:
    LGILGFFLFL | LLGITSLPSV | SNMVNWREFR | FVQSKLGYLT | LVLCTAHTLV | 
    450:
    YGGKRFLSPS | ILRWSLPSAY | ILALVIPCAV | LVLKCILIMP | CIDKTLTRIR | 
    470:
    QGWERNSKYT | QSALNGKSDI | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Metalloreductase STEAP4
    ELISA Kit for Mouse Metalloreductase STEAP4
    ELISA Kit for Mouse Metalloreductase STEAP4
    CLIA Kit for Mouse Metalloreductase STEAP4
    CLIA Kit for Mouse Metalloreductase STEAP4
    CLIA Kit for Mouse Metalloreductase STEAP4
    Polyclonal Antibody for Mouse Metalloreductase STEAP4
    Polyclonal Antibody for Mouse Metalloreductase STEAP4
    Polyclonal Antibody for Mouse Metalloreductase STEAP4
    Monoclonal Antibody for Mouse Metalloreductase STEAP4
    Monoclonal Antibody for Mouse Metalloreductase STEAP4
    Monoclonal Antibody for Mouse Metalloreductase STEAP4
    Protein for Mouse Metalloreductase STEAP4
    Protein for Mouse Metalloreductase STEAP4
    Protein for Mouse Metalloreductase STEAP4

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Tumor necrosis factor-alpha-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-alpha and adipose conversion."
      Moldes M. , Lasnier F. , Gauthereau X. , Klein C. , Pairault J. , Feve B. , Chambaut-Guerin A.-M.
      J. Biol. Chem.276:33938-33946(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INDUCTION BY TNFA
      strain: Swiss.
      tissue: Adipose tissue.
    2. 2.
      "Molecular cloning and expression of two new members of the dudulin family."
      Serru V. , Lamblin D. , Manivet P. , Pernet P. , Vaubourdolle M. , Kellermann O. , Loric S.
      Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Aorta.
      tissue: Vein.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    5. 5.
      "Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes."
      Fasshauer M. , Kralisch S. , Klier M. , Lossner U. , Bluher M. , Chambaut-Guerin A.-M. , Klein J. , Paschke R.
      FEBS Lett.560:153-157(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY IL6;TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME ACTIVITY
    7. 7.
      "Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis."
      Wellen K.E. , Fucho R. , Gregor M.F. , Furuhashi M. , Morgan C. , Lindstad T. , Vaillancourt E. , Gorgun C.Z. , Saatcioglu F. , Hotamisligil G.S.
      Cell129:537-548(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY TNFA;DISRUPTION PHENOTYPE
    8. 8.
      "Tumor necrosis factor alpha-induced adipose-related protein expression in experimental arthritis and in rheumatoid arthritis."
      Inoue A. , Matsumoto I. , Tanaka Y. , Iwanami K. , Kanamori A. , Ochiai N. , Goto D. , Ito S. , Sumida T.
      Arthritis Res. Ther.11:R118-R118(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY TNFA;TISSUE SPECIFICITY
    9. 9.
      "Interleukin-1beta is a positive regulator of TIARP/STAMP2 gene and protein expression in adipocytes in vitro."
      Kralisch S. , Sommer G. , Weise S. , Lipfert J. , Lossner U. , Kamprad M. , Schrock K. , Bluher M. , Stumvoll M. , Fasshauer M.
      FEBS Lett.583:1196-1200(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY IL1B
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